Special Issue | 11 January 2013Inflammation

This week's cover

INTRODUCTION—Inflammation, though beneficial during an infection, can contribute substantially to the pathogenesis of several age-related chronic diseases such as metabolic disease/type 2 diabetes, cardiovascular disease, and neurodegenerative disease. This special issue in Science, together with related content in Science Signaling, highlights the detrimental, but also in some cases beneficial, role of inflammation in chronic diseases. [Read the full introduction]


From Science

Review

Microglia: Scapegoat, Saboteur, or Something Else?

A. Aguzzi et al.
Microglia, the resident macrophage-like cells of the brain, play both protective and detrimental roles in neurodegenerative diseases.
Review

Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

F. K. Swirski and M. Nahrendorf
Cells of the immune system are central players in both disease pathogenesis and tissue repair in atherosclerosis and heart failure.
 
Review

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

I. Tabas and C. K. Glass
Strategies for developing anti-inflammatory therapies for chronic diseases like atherosclerosis are explored.
Review

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

J. I. Odegaard and A. Chawla
Inflammation and insulin resistance play important roles in shaping metabolic homeostasis and disease.

From Science Signaling

Editorial Guide

Focus Issue: Understanding Mechanisms of Inflammation

J. F. Foley
Inflammatory responses can be both beneficial and detrimental.
Research Resource

Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation

U. auf dem Keller et al.
Quantitative proteomic analysis of inflamed mouse skin reveals mediators of the inflammatory response in vivo.
Research Resource

A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-κB Signaling Pathways

N. Warner et al.
A small interfering RNA screen provides insight into the mechanisms of Crohn’s disease pathogenesis.
 
Perspective

The FLIP Side of Life

J. Silke and A. Strasser
The protein c-FLIP plays a role in preventing cell death by both apoptosis and necroptosis.
Perspective

Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases

L. Steinman
Four cytokines play complex roles in neuroinflammatory diseases.
Podcast

Science Signaling Podcast

G. Núñez and A. M. VanHook
 
Identification of inflammatory response regulators sheds light on disease.
 
Podcast
 
Listen to an inteview with Ira Tabas on progress in treating inflammation in chronic disease.

Also in this Special Issue:

Related Resources

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