Special Issue | 11 January 2013Inflammation
INTRODUCTION—Inflammation, though beneficial during an infection, can contribute substantially to the pathogenesis of several age-related
chronic diseases such as metabolic disease/type 2 diabetes, cardiovascular disease, and neurodegenerative disease. This special
issue in Science, together with related content in Science Signaling, highlights the detrimental, but also in some cases beneficial, role of inflammation in chronic diseases. [Read the full introduction]
From Science
Review
A. Aguzzi et al.
Microglia, the resident macrophage-like cells of the brain, play both protective and detrimental roles in neurodegenerative
diseases.
Review
F. K. Swirski and M. Nahrendorf
Cells of the immune system are central players in both disease pathogenesis and tissue repair in atherosclerosis and heart
failure.
Review
I. Tabas and C. K. Glass
Strategies for developing anti-inflammatory therapies for chronic diseases like atherosclerosis are explored.
Review
J. I. Odegaard and A. Chawla
Inflammation and insulin resistance play important roles in shaping metabolic homeostasis and disease.
From Science Signaling
Editorial Guide
J. F. Foley
Inflammatory responses can be both beneficial and detrimental.
Research Resource
U. auf dem Keller et al.
Quantitative proteomic analysis of inflamed mouse skin reveals mediators of the inflammatory response in vivo.
Research Resource
N. Warner et al.
A small interfering RNA screen provides insight into the mechanisms of Crohn’s disease pathogenesis.
Perspective
J. Silke and A. Strasser
The protein c-FLIP plays a role in preventing cell death by both apoptosis and necroptosis.
Perspective
L. Steinman
Four cytokines play complex roles in neuroinflammatory diseases.
Podcast
G. Núñez and A. M. VanHook
Identification of inflammatory response regulators sheds light on disease.
Podcast
Listen to an inteview with Ira Tabas on progress in treating inflammation in chronic disease.
Also in this Special Issue:
Science Special Issues
30 January 2015
23 January 2015
19 December 2014
21 November 2014
31 October 2014
10 October 2014
More Special Issues >>