Science Translational Medicine

Science Translational Medicine

Integrating Medicine and Science

Coming Fourth Quarter 2009

Abbreviated Instructions for Authors of Research Articles

Scope: Science Translational Medicine will publish articles containing original, science-based research that reports successful progress toward improvements in clinical medicine. Papers from a wide variety of disciplines are welcome; interdisciplinary studies are especially suitable for this journal. Included within the scope are a broad array of traditional medical specialties including (but not limited to) cardiovascular medicine, cancer, immunology, neurology, psychiatry, metabolic diseases, radiology and imaging. Approaches applicable to all stages of the translational process are appropriate: bioengineering, drug discovery, diagnostics, biomarkers, pharmacokinetics, drug delivery, gene therapy and regenerative medicine.

Criteria and process for evaluation: Research Articles should report major advances and the results should represent substantial progress toward improving diagnosis or treatment of a disease. They should be of strong interdisciplinary interest within medicine or of unusual interest within a specialty. Papers will be evaluated for their importance, technical rigor and novelty. All papers will undergo an initial screening by staff editors and the Advisory Board. Only those most likely to be ultimately published will be sent out for in depth peer review. Science Translational Medicine is committed to a rapid, thorough and fair peer-review process.

Format: Research Articles should be 5-7000 words (including legends and references), with 5-7 figures plus tables. They should include an Abstract and the following sections: Introduction, Results, Discussion, Materials and Methods, References and Notes, Tables. Supplementary material is permitted but should be limited to information that is not essential to the understanding and evaluation of the research presented in the paper. Use double spacing throughout the manuscript, formatted for U.S. letter paper. Symbols, abbreviations, and acronyms should be defined the first time they are used. All references, tables, and figures should be cited in numerical order.

Each submission should include a one-sentence summary capturing the most important point of your paper.


Title should be no more than 90 characters (including spaces).

Authors and their affiliated institutions, linked by superscript numbers, should be listed beneath the title on the opening page of the manuscript.

The abstract (<125 words) should present background information to convey the context of the research, give a general idea of the methodology used, describe the results, and draw general conclusions. The Abstract is distinct from the main body of the text, and thus should not be the only source of background information critical to understanding the manuscript. Do not include citations or undefined abbreviations in the Abstract.

Introduction: The introduction should provide sufficient background information to make the article intelligible to readers in other disciplines, and sufficient context that the significance of the experimental findings is clear.

Results: The results, describing the experiments performed and the findings observed, should be divided into subheadings to delineate different experimental themes.

Discussion: The discussion describes the conclusions that can be drawn from the results and discusses the significance and implications of the research.

Materials and Methods: The materials and methods should provide sufficient detail to allow replication of the results (standard methods may be referenced without a detailed description).

References and notes are numbered in the order in which they are cited, first through the text, and then through the figure and table legends. Each reference should have a unique number; do not combine references or embed references in notes. Do not use op. cit. or ibid.

Acknowledgments must be gathered into the last numbered reference and include thanks to others for help or materials. It should also include complete funding information, accession numbers, and any information related to authorship conflict of interest.

Tables should be included after the references. The first sentence of the table legend should be a brief descriptive title. Every vertical column should have a heading, consisting of a title with the unit of measure in parentheses. Units should not change within a column.

Figures should be submitted as part of the online submission or, if necessary for large files only, on a CD. See Instructions for the Electronic Submission of Text and Figures below for allowable formats for submission and information on preparing art.

Graphs must be labeled on the ordinate and abscissa with the parameter or variable being measured, the units of measure, and the scale. Scales with large or small numbers should be presented as powers of 10. Simple solid or open symbols reduce well. Avoid the use of light lines and screen shading. Instead, use black-and-white, hatched, and cross-hatched designs for emphasis.

Micrographs Use scale bars in place of, or in addition to, magnifications. When figures are assembled from multiple gels or micrographs, a line or space should indicate the border between two original images. No part of a figure may be selectively manipulated.

Units of measure should be given in SI units. If measurements were made in English units, give metric equivalents.

Figure legends begin with the figure title as the first line of the legend. No single legend should be longer than ~500 words. Nomenclature, abbreviations, symbols, and units used in a figure should match those used in the text.

Supplementary material should supplement the research presented in the paper, provide data tables, extra information or controls. Supplemental movies or audio files may be included in SM. Although audio and video files are welcome, they cannot be submitted through the online submission system. Please contact the editors at scitranslmededitors{at}aaas.org regarding submission of these file types.

Author Checklist for Science Translational Medicine Research Articles

Are all authors listed correctly along with their affiliations and the corresponding author indicated?

Have you included a one-sentence summary of your paper?

Have you included an Abstract?

Have you defined all symbols, abbreviations, and acronyms?

Have you included legends for all figures and tables?

Are the references complete? Each citation should include full article title, journal title, journal volume, year of publication, and first and last page. Please include all authors (do not use et al.).

Instructions for Preparing Your Files and Electronic Submission of Text and Figures for New Manuscripts

Submit your Research Article through http://www.submit2scitranslmed.org

Naming your Files

Our electronic submission form will only accept files with the correct extension designating the file type. Name all files starting with the last name of the first author. Follow this by an indication of whether this is the text or the figure name. End the file name with the extension.

Acceptable file names:

  • smithtext.doc
  • smithtextfigs.prn
  • smithfig1.eps
  • smithtextfigs.ps
  • smithms.ps
  • smithsupp.pdf

Unacceptable file names:

  • smithfig1C.ps (each figure should be complete, not broken into parts)
  • smithtext (all files should end in a file extension)

Maximum file size.The maximum total file size for each submission through the web site is 7 MB (including figures and supplementary material). If you have larger figure or supplementary material files, contact the editors at scitranslmededitors{at}aaas.org for instructions about sending the large files.

Acceptable text file format and configurations The best configuration for initial submission is to submit one pdf file containing all of the text together with embedded graphic files (in allowable formats (see below)). If any of the figures are half tones or complicated graphics, however, the figure files will need to be uploaded separately (Either embed all or none of the figures; do not embed some.) When possible, supplementary information should be included at the end as part of the document.

Acceptable formats for text files (with or without embedded graphics) in order of preference:

  • .pdf (Adobe Portable Document Format)
  • .doc (Microsoft Word, version 6.0 and higher) - We cannot accept files in Word 2007 (.docx) format.
  • .ps (PostScript)
  • .eps (Encapsulated PostScript)
  • .prn (Printer file for a PostScript printer)
  • .wpd (WordPerfect, version 7.0 and higher)

More information about creating acceptable files can be found on the Science website (http://www.sciencemag.org/about/authors/prep/prep_init.xhtml#formats) including how to properly save Word 2007 files and TeX and LaTeX files.

Graphic and figure file format

Graphic files should be sized to fit on 1 page (8.5" by 11") at a resolution of no higher than 300 dots per inch (dpi). Higher resolution files will be requested upon acceptance for publication. An identifying number (e.g., "Fig. 1") must be included on the same page as any separate figure.
Acceptable formats for graphic and figure files:

  • .ps
  • .eps
  • .pdf

Photoshop files should be saved as .ps, .eps, or .pdf files. Adobe Illustrator also supports export to PDF format in version 7.0.

For tips on making figures, see http://www.sciencemag.org/about/authors/prep/prep_subfigs.xhtml\
on the Science Magazine web site.

Supplementary Material

Text and graphic file formats. Include supplementary text, tables, figures, and references at the end of the main manuscript file, in a separate section titled "Supplementary Material," when the total file size does not exceed 6 MB. If necessary, Supplementary Material can be included as a separate file (acceptable formats: .pdf, .ps, .prn, .doc, .wpd) uploaded as the final figure file within the 6 MB upload limit. Contact the editors at scitranslmededitors{at}aaas.org regarding submission of supplementary material that exceeds the 6 MB limit.

Audio, video and other file formats. Acceptable formats for videos are Quicktime, MPEG, and Flash. Keep videos short and the display window small to minimize the file size. Supply caption information with the videos. Edit longer sequences into several small pieces with captions specific to each video sequence. If your supplementary material is a video or audio file, or an excel file, you should contact the editors at scitranslmededitors@aaas.org for instructions on submitting those files. Include the confirmation number you received during the upload of your paper in your correspondence.

Citation style

References and notes are numbered in the order in which they are cited, first through the text, then through the table and figure legends. List a reference only once. Any references to in-press manuscripts or personal communications should be given a number in the text and placed, in correct sequence, in the references and notes.

The abbreviations for journal names are taken from the Bibliographic Guide for Editors and Authors (BGEA) or Serial Sources for the BIOSIS Data Base (BIOSIS). When in doubt, provide the journal's complete name. Do not use op. cit., ibid., 3-m dashes, en dashes, or et al.
Please supply full citations to journal articles in the following format:

E. J. Neer, T. Kozasa, Sites for Gα binding on the G protein β subunit overlap with sites for regulation of phospholipase Cβ and adenylyl cyclase. J. Biol. Chem. 273, 16265-16272 (1998).