Science Functional Genomics

Over the years, Science has consistently stood at the forefront of publishing epigenetics research -- from pioneering work on the role of histones in gene regulation and early reviews of topics such as heterochromatin during the 1960s, to recent, groundbreaking studies in areas such as DNA methylation and RNAi. To provide additional context for the overview of the field provided in the journal's 10 August 2001 special issue on epigenetics, we present here a selection of Science Research Articles, Reports, Reviews, Perspectives, and news articles that help trace out some of the field's landmarks of the past half-decade. (Be sure also to visit our page of epigenetics Web resources, as well as other sections of the Science Functional Genomics Web site.)

[Access note: The full text of Research Articles and Reports more than 12 months old is free to all registered users of Science Online; full text for Reviews, Perspectives, and news requires a paid subscription.]

General Reviews on Epigenetics

Review: Unique Chromatin Remodeling and Transcriptional Regulation in Spermatogenesis
Paolo Sassone-Corsi
Science, 21 June 2002, p. 2176-2178
[Abstract][Full Text]

Review: Visualizing Chromatin Dynamics in Interphase Nuclei
Susan M. Gasser
Science, 24 May 2002, p. 1412-1416
[Abstract][Full Text]

The Evolution of Epigenetics
Guy Riddihough and Elizabeth Pennisi
Science, 10 August 2001, p. 1063

News: Behind the Scenes of Gene Expression
Elizabeth Pennisi
Science, 10 August 2001, p. 1064-1067
[Abstract][Full Text]

Review: The Centromere Paradox: Stable Inheritance with Rapidly Evolving DNA
Steven Henikoff, Kami Ahmad, and Harmit S. Malik
Science, 10 August 2001, p. 1098-1102
[Abstract][Full Text]

Viewpoint:Genes, Genetics, and Epigenetics: A Correspondence
C.-t. Wu and J. R. Morris
Science, 10 August 2001, p. 1103-1105
[Abstract][Full Text]

Review: Insulators and Boundaries: Versatile Regulatory Elements in the Eukaryotic Genome
Adam C. Bell, Adam G. West, and Gary Felsenfeld
Science, 19 January 2001, p. 447-450
[Abstract][Full Text]

Review: Epigenetics: Regulation Through Repression
Alan Wolffe and Marjori Matzke
Science, 15 October 1999, p. 481-486
[Abstract][Full Text]

Review: Structure and Function in the Nucleus
Angus I. Lamond and William C. Earnshaw
Science, 24 April 1998, pp. 547-553
[Abstract][Full Text]

Histone Modification and Gene Expression

Role of Histone H3 Lysine 27 Methylation in X Inactivation
Kathrin Plath et al.
Science, 4 April 2003, p. 131-135; published online March 20, 2003; 10.1126/science.1084274
[Abstract][Full Text]

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation
Daniel Zilberman, Xiaofeng Cao, and Steven E. Jacobsen
Science, 31 January 2003, p. 716-719; published online January 9, 2003; 10.1126/science.1079695
[Abstract][Full Text]

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells
Richard Festenstein et al.
Science, 31 January 2003, p. 719-721
[Abstract][Full Text]

Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding
Thierry Cheutin et al.
Science, 31 January 2003, p. 721-725
[Abstract][Full Text]

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Ru Cao et al.
Science, 1 November 2002, p. 1039-1043; published online September 26, 2002; 10.1126/science.1076997
[Abstract][Full Text]

Establishment and Maintenance of a Heterochromatin Domain
Ira M. Hall et al.
Science, 27 September 2002, p. 2232-2237; published online September 5, 2002; 10.1126/science.1076466
[Abstract][Full Text]

An RNA-Guided Pathway for the Epigenome

Thomas Jenuwein
Science, 27 September 2002, p. 2215-2218
[Summary][Full Text]

Genomic Instability in Mice Lacking Histone H2AX
A. Celeste et al.
Science, 3 May 2002, p. 922-927; published online April 4, 2002, 10.1126/science.1069398
[Abstract][Full Text]

Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail
Steven A. Jacobs and Sepideh Khorasanizadeh
Science, 15 March 2002, p. 2080-2083; published online February 21, 2002, 10.1126/science.1069473
[Abstract][Full Text]

Requirement of Heterochromatin for Cohesion at Centromeres
Pascal Bernard et al.
Science, 21 December 2001, p. 2539-2542; published online October 11, 2001, 10.1126/science.1064027
[Abstract][Full Text]

Perspective: MOLECULAR BIOLOGY: Methylation Talk Between Histones and DNA
Adrian Bird
Science, 7 December 2001, pp. 2113-2115
[Summary][Full Text]

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus
Michael D. Litt, Melanie Simpson, Miklos Gaszner, C. David Allis, and Gary Felsenfeld
Science, 28 September 2001, pp. 2453-2455
[Abstract][Full Text]

Review: Translating the Histone Code
Thomas Jenuwein and C. David Allis
Science, 10 August 2001, pp. 1074-1080
[Abstract][Full Text]

Snf1--a Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription
Wan-Sheng Lo et. al
Science, 10 August 2001, pp. 1142-1146
[Abstract][Full Text]

Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries
Ken-ichi Noma, C. David Allis, and Shiv I. S. Grewal
Science, 10 August 2001, pp. 1150-1155
[Abstract][Full Text]

Methylation of Histone H4 at Arginine 3 Facilitates Transcriptional Activation by Nuclear Hormone Receptor
Hengbin Wang et al.
Science, 3 August 2001, pp. 853-857
[Abstract][Full Text]

Telomere Position Effect in Human Cells
Joseph A. Baur, Ying Zou, Jerry W. Shay, and Woodring E. Wright
Science, 15 June 2001, pp. 2075-2077
[Abstract][Full Text]

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Jun-ichi Nakayama, Judd C. Rice, Brian D. Strahl, C. David Allis, and Shiv I. S. Grewal
Science, 6 April 2001, pp. 110-113
[Abstract][Full Text]

Perspective: MOLECULAR BIOLOGY: The Histone Modification Circus
Shelley L. Berger
Science, 6 April 2001, pp. 64-65
[Summary][Full Text]

Ubiquitin-Activating/Conjugating Activity of TAFII250, a Mediator of Activation of Gene Expression in Drosophila
Anh-Dung Pham and Frank Sauer
Science, 29 September 2000, pp. 2357-2360
[Abstract][Full Text]

Perspective: TRANSCRIPTION: New Insights into an Old Modification
Craig A. Mizzen and C. David Allis
Science, 29 September 2000, pp. 2290-2291
[Summary][Full Text]

Structure and Function of a Human TAFII250 Double Bromodomain Module
Raymond H. Jacobson, Andreas G. Ladurner, David S. King, and Robert Tjian
Science, 26 May 2000, pp. 1422-1425
[Abstract][Full Text]

A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination
Michelle Taylor McMurry and Michael S. Krangel
Science, 21 January 2000, pp. 495-498
[Abstract][Full Text]

Perspective: TRANSCRIPTION: A Tail of Histone Acetylation and DNA Recombination
Mark S. Schlissel
Science, 21 January 2000, pp. 438-440
[Summary][Full Text]

Rad6-Dependent Ubiquitination of Histone H2B in Yeast
Kenneth Robzyk, Judith Recht, and Mary Ann Osley
Science, 21 January 2000, pp. 501-504
[Abstract][Full Text]

News: CELL BIOLOGY: How Chromatin Changes Its Shape
Michael Hagmann
Science, 20 August 1999, p. 1200-1203
[Summary][Full Text]

Perspective: CHROMOSOME STRUCTURE: How to Compact DNA
Andrew W. Murray
Science, 16 October 1998, pp. 425-427
[Summary][Full Text]

Identification of Maize Histone Deacetylase HD2 as an Acidic Nucleolar Phosphoprotein
Alexandra Lusser, Gerald Brosch, Adele Loidl, Hubertus Haas, Peter Loidl
Science, 4 July 1997, pp. 88-91
[Abstract][Full Text]

News: MOLECULAR BIOLOGY: Opening the Way to Gene Activity
Elizabeth Pennisi
Science, 10 January 1997, pp. 155-157
[Summary][Full Text]

Perspective: TRANSCRIPTION: Getting Around the Nucleosomes
Jonathan Widom
Science, 12 December 1997, pp. 1899-1901
[Summary][Full Text]

An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres
Dmitry Pruss et. al
Science, 25 October 1996, pp. 614-617
[Abstract][Full Text]

DNA Methylation, Transcriptional Gene Silencing, Epigenetic Inheritance, and Imprinting

Brevia:Chromosomal Instability and Tumors Promoted by DNA Hypomethylation
Amir Eden, François Gaudet, Alpana Waghmare, and Rudolf Jaenisch
Science, 18 April 2003, p. 455
[Full Text]

Induction of Tumors in Mice by Genomic Hypomethylation
François Gaudet et al.
Science, 18 April 2003, p. 489-492
[Abstract][Full Text]

An Unstable Liaison

Christoph Lengauer
Science, 18 April 2003, p. 442-443
[Summary][Full Text]

Regulation of the Different Chromatin States of Autosomes and X Chromosomes in the Germ Line of C. elegans
Youyi Fong, Laurel Bender, Wenchao Wang, and Susan Strome
Science, 21 June 2002, p. 2235-2238
[Abstract][Full Text]

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells
Hidesato Ogawa, Kei-ichiro Ishiguro, Stefan Gaubatz, David M. Livingston, and Yoshihiro Nakatani
Science, 10 May 2002, p. 1132-1136
[Abstract][Full Text]

Perspective: TRANSCRIPTION: Chromatin Control--a Place for E2F and Myc to Meet
Nicholas B. La Thangue
Science, 10 May 2002, p. 1034-1035
[Summary][Full Text]

Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor
Luciano Di Croce et al.
Science, 8 February 2002, p. 1079-1082
[Abstract][Full Text]

Leukemia Protein Spurs Gene Silencing

Jean Marx
Science, 8 February 2002, p. 943-945
[Summary][Full Text]

Faithful Expression of Imprinted Genes in Cloned Mice
K. Inoue et al.
Science, 11 January 2002, p. 297
[Full Text]

CTCF, a Candidate Trans-Acting Factor for X-Inactivation Choice
Wendy Chao, Khanh D. Huynh, Rebecca J. Spencer, Lance S. Davidow, and Jeannie T. Lee
Science, 11 January 2002, p. 345-347; published online December 6, 2001, 10.1126/science.1065982
[Abstract][Full Text]

Perspective: GENETICS: Do X Chromosomes Set Boundaries?
Ivona Percec and Marisa S. Bartolomei
Science, 11 January 2002, p. 287-288
[Summary][Full Text]

A Transcriptional Switch Mediated by Cofactor Methylation
Wei Xu et al.
Science, 21 December 2001, p. 2507-2511; published online November 8, 2001, 10.1126/science.1065961
[Abstract][Full Text]

Perspective: TRANSCRIPTION: Switching Partners in a Regulatory Tango
Kenichi Nishioka and Danny Reinberg
Science, 21 December 2001, p. 2497-2498
[Summary][Full Text]

Dnmt3L and the Establishment of Maternal Genomic Imprints
D±borah Bourc'his, Guo-Liang Xu, Chyuan-Sheng Lin, Brooke Bollman, and Timothy H. Bestor
Science, 21 December 2001, p. 2536-2539; published online November 22, 2001, 10.1126/science.1065848
[Abstract][Full Text]

Trithorax and dCBP Acting in a Complex to Maintain Expression of a Homeotic Gene
Svetlana Petruk, et al.
Science, 9 November 2001, pp. 1331-1334
[Abstract][Full Text]

Review:The Role of DNA Methylation in Mammalian Epigenetics
Peter A. Jones and Daiya Takai
Science, 10 August 2001, pp. 1068-1070
[Abstract][Full Text]

Viewpoint:DNA Methylation and Epigenetic Inheritance in Plants and Filamentous Fungi
Robert A. Martienssen and Vincent Colot
Science, 10 August 2001, pp. 1070-1073
[Abstract][Full Text]

Viewpoint:Epigenetic Aspects of X-Chromosome Dosage Compensation
Yongkyu Park and Mitzi I. Kuroda
Science, 10 August 2001, pp. 1083-1085
[Abstract][Full Text]

Review: Imprinting and the Epigenetic Asymmetry Between Parental Genomes
Anne C. Ferguson-Smith and M. Azim Surani
Science, 10 August 2001, pp. 1086-1089
[Abstract][Full Text]

Review: Epigenetic Reprogramming in Mammalian Development
Wolf Reik, Wendy Dean, and J±rn Walter
Science, 10 August 2001, pp. 1089-1093
[Abstract][Full Text]

Viewpoint:Nuclear Cloning and Epigenetic Reprogramming of the Genome
William M. Rideout III, Kevin Eggan, and Rudolf Jaenisch
Science, 10 August 2001, pp. 1093-1098
[Abstract][Full Text]

Epigenetic Instability in ES Cells and Cloned Mice
David Humpherys et. al
Science, 6 July 2001, pp. 95-97
[Abstract][Full Text]

Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation
Anders M. Lindroth et. al
Science, 15 June 2001, p. 2077-2080
[Abstract][Full Text]

X-Chromosome Inactivation in Cloned Mouse Embryos
Kevin Eggan, Hidenori Akutsu, Konrad Hochedlinger, William Rideout III, Ryuzo Yanagimachi, and Rudolf Jaenisch
Science, 24 November 2000, p. 1578-1581
[Abstract][Full Text]

Perspective: GENETICS: Reprogramming X Inactivation
Phillipe Clerc and Philip Avner
Science, 24 November 2000, p. 1518-1519
[Summary][Full Text]

Perspective:MOLECULAR BIOLOGY: Mothers Setting Boundaries
Joanne L. Thorvaldsen and Marisa S. Bartolomei
Science, 23 June 2000, pp. 2145-2146
[Summary][Full Text]

News: GENETICS: Was Lamarck Just a Little Bit Right?
Michael Balter
Science, 7 April 2000, p. 38
[Summary][Full Text]

Perspective: MOLECULAR BIOLOGY: DNA Methylation de Novo
Adrian Bird
Science, 17 December 1999, p. 2287-2288
[Summary][Full Text]

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator
Giacomo Cavalli and Renato Paro
Science, 29 October 1999, pp. 955-958
[Abstract][Full Text]

Silencing of Genes Flanking the P1 Plasmid Centromere
Oleg Rodionov, Małgorzata Łobocka, and Michael Yarmolinsky
Science, 22 January 1999, pp. 546-549
[Abstract][Full Text]

Inactivation of Misselected CD8 T Cells by CD8 Gene Methylation and Cell Death
Gary A. Pestano, Yaling Zhou, Linda A. Trimble, John Daley, Georg F. Weber, and Harvey Cantor
Science, 14 May 1999, p. 1187-1191
[Abstract][Full Text]

An Essential Role for DNA Adenine Methylation in Bacterial Virulence
Douglas M. Heithoff, Robert L. Sinsheimer, David A. Low, and Michael J. Mahan
Science, 7 May 1999, p. 967-970
[Abstract][Full Text]

Nonmethylated Transposable Elements and Methylated Genes in a Chordate Genome
Martin W. Simmen et al.
Science, 19 February 1999, pp. 1164-1167
[Abstract][Full Text]

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1
Linda S.-H. Chuang et al.
Science, 26 September 1997, pp. 1996-2000
[Abstract][Full Text]

Perspective: DNA METHYLATION: Tying It All Together: Epigenetics, Genetics, Cell Cycle, and Cancer
Stephen B. Baylin
Science, 26 September 1997, pp. 1948-1949
[Summary][Full Text]

Hypermethylated SUPERMAN Epigenetic Alleles in Arabidopsis
Steven Jacobson and Elliot Meyerowitz
Science, 22 August 1997, p. 1100-1103
[Abstract][Full Text]

Demethylation-Induced Developmental Pleiotropy in Arabidopsis
Michael J. Ronemus, Massimo Galbiati, Christine Ticknor, Jychian Chen, and Stephen L. Dellaporta
Science, 2 August 1996, p. 654-657

Gametic Imprinting in Mammals
Denise P. Barlow
Science, 8 December 1995, p. 1610-1613

Posttranscriptional Gene Silencing and RNA Interference

Cleavage of Scarecrow-like mRNA Targets Directed by a Class of Arabidopsis miRNA
Cesar Llave, Zhixin Xie, Kristin D. Kasschau, and James C. Carrington
Science, 20 September 2002, p. 2053-2056
[Abstract][Full Text]

A microRNA in a Multiple-Turnover RNAi Enzyme Complex
György Hutvágner and Phillip D. Zamore
Science, 20 September 2002, p. 2056-2060; published online August 1, 2002; 10.1126/science.1073827
[Abstract][Full Text]

Perspective:DNA EVENTS:
An RNA Microcosm

David Baulcombe
Science, 20 September 2002, p. 2002-2003
[Summary][Full Text]

Brevia:Small RNAs Correspond to Centromere Heterochromatic Repeats
Brenda J. Reinhart and David P. Bartel
Science, 13 September 2002, p. 1831; published online August 22, 2002; 10.1126/science.1077183
[Full Text]

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
Thomas A. Volpe et al.
Science, 13 September 2002, p. 1833-1837; published online August 22, 2002; 10.1126/science.1074973
[Abstract][Full Text]

Dependence of Heterochromatic Histone H3 Methylation Patterns on the Arabidopsis Gene DDM1
Anne-Valérie Gendrel, Zachary Lippman, Cristy Yordan, Vincent Colot, and Robert A. Martienssen
Science, 13 September 2002, p. 1871-1873; published online June 20, 2002; 10.1126/science.1074950
[Abstract][Full Text]

RNAi and Heterochromatin--a Hushed-Up Affair

Robin Allshire
Science, 13 September 2002, p. 1818-1819; published online August 22, 2002; 10.1126/science.1075874
[Summary][Full Text]

Viewpoint:An Expanding Universe of Noncoding RNAs
Gisela Storz
Science, 17 May 2002, pp. 1260-1263
[Abstract][Full Text]

Viewpoint:RNA Silencing: The Genome's Immune System
Ronald H. A. Plasterk
Science, 17 May 2002, pp. 1263-1265
[Abstract][Full Text]

Viewpoint:Ancient Pathways Programmed by Small RNAs
Phillip D. Zamore
Science, 17 May 2002, pp. 1265-1269
[Abstract][Full Text]

Review:RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing
Paul Ahlquist
Science, 17 May 2002, pp. 1270-1273
[Abstract][Full Text]

Induction and Suppression of RNA Silencing by an Animal Virus
Hongwei Li, Wan Xiang Li, and Shou Wei Ding
Science, 17 May 2002, pp. 1319-1321
[Abstract][Full Text]

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
Thijn R. Brummelkamp, Ren± Bernards, and Reuven Agami
Science, 19 April 2002, p. 550-553; published online 21 March 2002, 10.1126/science.1068999
[Abstract][Full Text]

RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs
Marcel Tijsterman, René F. Ketting, Kristy L. Okihara, Titia Sijen, and Ronald H. A. Plasterk
Science, 25 January 2002, pp. 694-697
[Abstract][Full Text]

Identification of Novel Genes Coding for Small Expressed RNAs
Mariana Lagos-Quintana, Reinhard Rauhut, Winfried Lendeckel, and Thomas Tuschl
Science, 26 October 2001, pp. 853-858
[Abstract][Full Text]

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Nelson C. Lau, Lee P. Lim, Earl G. Weinstein, and David P. Bartel
Science, 26 October 2001, pp. 858-862
[Abstract][Full Text]

An Extensive Class of Small RNAs in Caenorhabditis elegans
Rosalind C. Lee and Victor Ambros
Science, 26 October 2001, pp. 862-864
[Abstract][Full Text]

Perspectives: MOLECULAR BIOLOGY: Glimpses of a Tiny RNA World
Gary Ruvkun
Science, 26 October 2001, pp. 797-799
[Summary][Full Text]

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans
Scott W. Knight and Brenda L. Bass
Science, 21 September 2001, pp. 2269-2271
[Abstract][Full Text]

Viewpoint:RNA: Guiding Gene Silencing
Marjori Matzke, Antonius J. M. Matzke, and Jan M. Kooter
Science, 10 August 2001, pp. 1080-1083
[Abstract][Full Text]

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi
S. M. Hammond et. al
Science, 10 August 2001, pp. 1146-1150
[Abstract][Full Text]

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA
György Hutvágner et al.
Science, 3 August 2001, pp. 834-838
[Abstract][Full Text]

Perspectives: DEVELOPMENT: Dicing Up RNAs
V. Ambros
Science, 3 August 2001, pp. 811-813
[Summary][Full Text]

Review: RNA Silencing in Plants--Defense and Counterdefense
Vicki Vance and Hervé Vaucheret
Science, 22 June 2001, pp. 2277-2280
[Abstract][Full Text]

News: GENE SILENCING: A Faster Way to Shut Down Genes
R. John Davenport
Science, 25 May 2001, pp. 1469-1471
[Summary][Full Text]

Transgene and Transposon Silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA Helicase
Dancia Wu-Scharf, Byeong-ryool Jeong, Chaomei Zhang, and Heriberto Cerutti
Science, 10 November 2000, pp. 1159-1162
[Abstract][Full Text]

Perspective: MOLECULAR BIOLOGY: Unwinding RNA Silencing
David C. Baulcombe
Science, 10 November 2000, pp. 1108-1109
[Summary][Full Text]

A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants
Radhamani Anandalakshmi et al.
Science, 6 October 2000, pp. 142-144
[Abstract][Full Text]

A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans
Mary Ellen Domeier et al.
Science, 15 September 2000, pp. 1928-1930
[Abstract][Full Text]

News: Interfering With Gene Expression
Jean Marx
Science, 26 May 2000, pp. 1370-1372
[Summary][Full Text]

Genetic Requirements for Inheritance of RNAi in C. elegans
Alla Grishok, Hiroaki Tabara, and Craig C. Mello
Science, 31 March 2000, pp. 2494-2497
[Abstract][Full Text]

Perspective: MOLECULAR BIOLOGY: RNA Interference
Phillip A. Sharp and Phillip D. Zamore
Science, 31 March 2000, pp. 2431-2433
[Summary][Full Text]

Posttranscriptional Gene Silencing in Neurospora by a RecQ DNA Helicase
Carlo Cogoni and Giuseppe Macino
Science, 17 December 1999, pp. 2342-2344
[Abstract][Full Text]

A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants
Andrew J. Hamilton and David C. Baulcombe
Science, 29 October 1999, pp. 950-952
[Abstract][Full Text]

News: MOLECULAR BIOLOGY: Candidate 'Gene Silencers' Found
Evelyn Strauss
Science, 29 October 1999, p. 886
[Summary][Full Text]

Tech.Sight: REVERSE GENETICS: RNAi in C. elegans: Soaking in the Genome Sequence
Hiroaki Tabara, Alla Grishok, and Craig C. Mello
Science, 16 October 1998, pp. 430-431
[Summary][Full Text]

A Similarity Between Viral Defense and Gene Silencing in Plants
Frank Ratcliff, Bryan D. Harrison, and David C. Baulcombe
Science, 6 June 1997, pp. 1558-1560
[Abstract][Full Text]

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