Breakthrough of the Year 2008:
References and Web Links

Online Extras on Reprogramming Cells

Papers and Articles

I. Park et al., "Disease-Specific Induced Pluripotent Stem Cells," Cell 134, 877-886 (2008)

P. Gadue and G. Cotsarelis, "Epidermal Cells Rev Up Reprogramming," Nature Biotechnology 26, 1243 (2008)

N. Maherali et al., "A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells," Cell Stem Cell 3, 340-345 (2008)

J. Hanna et al., "Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency," Cell 133, 250-264 (2008)

A. Marson et al., "Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency," Cell Stem Cell 3, 132-135 (2008)

M. Wernig et al., "A Drug-Inducible Transgenic System for Direct Reprogramming of Multiple Somatic Cell Types," Nature Biotechnology 26, 916-294 (2008)

R. Blelloch, "Short Cut to Cell Replacement," Nature 455, 604 (2008)

Q. Zhou1 et al., "In vivo Reprogramming of Adult Pancreatic Cxocrine Cells to β-Cells," Nature 455, 627 (2008)

T. S. Mikkelsen et al., "Dissecting Direct Reprogramming Through Integrative Genomic Analysis," Nature 454, 49-55 (2008)

D. Huangfu et al., "Induction of Pluripotent Stem Cells from Primary Human Fibroblasts with Only Oct4 and Sox2," Nature Biotechnology 26, 1269-1275 (2008)

T. Aasen, "Efficient and Rapid Generation of Induced Pluripotent Stem Cells from Human Keratinocytes," Nature Biotechnology 26, 1276-1284 (2008)

J. T. Dimos, et al., "Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons," Science 321, 1218 (2008)

M. Wernig et al., "Neurons Derived from Reprogrammed Fibroblasts Functionally Integrate into the Fetal Brain and Improve Symptoms of Rats with Parkinson's Disease," Proc. Nat. Acad. Sci. 105, 5856-5861 (2008)

M. F. Pera, "A New Year and a New Era," Nature 451, 135 (2008)

J. B. Kim, "Pluripotent Stem Cells Induced from Adult Neural Stem Cells by Reprogramming with Two Factors," Nature 454, 646 (2008)

M. Stadtfeld et al., "Induced Pluripotent Stem Cells Generated Without Viral Integration," Science 322, 945-949 (2008);; published online 25 September 2008 [DOI: 10.1126/science.1162494]

T. Aoi et al., "Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells," Science 321, 699 (2008); published online 12 February 2008 [DOI: 10.1126/science.1154884]

M. Nakagawa et al., "Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts," Nature Biotechnology 26 101-106 (2008)

S. Yamanaka, "Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells," Cell Stem Cell 1, 39-49 (2007)

K. Okita, et al., "Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors," Science 322, 949 (2008); published online 8 October 2008 [DOI: 10.1126/science.1164270]

C. Holden, "Biologists Change One Cell Type Directly Into Another," Science 321, 1143(2008)

A. G. Bang and M. K. Carpenter, "Deconstructing Pluripotency," Science 320, 58-59 4 April 2008 320: 58-59 (2008)

C. Holden and G. Vogel, "A Seismic Shift for Stem Cell Research," Science 319, 560-563 (2008)

D. Normile, "Shinya Yamanaka: Modest Researcher, Results to Brag About," Science 319, 562 (2008)

C. Holden and G. Vogel, "Nuclear Transfer: Still on the Table," Science 319, 563 (2008)


Interesting Web Sites

International Society for Stem Cell Research
A rich resource on stem cells including a news archive and information for scientists and general readers.

NIH Stem Cell Information
Comprehensive resource about U.S. federal research policy and stem cells that includes links to news and funding opportunities.

Information on specific diseases: