125th Anniversary Issue
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In Science Magazine
In Science's STKE
In Science's SAGE KE
In Science's Next Wave

In a special collection of articles published beginning 1 July 2005, Science Magazine and its online companion sites celebrate the journal's 125th anniversary with a look forward -- at the most compelling puzzles and questions facing scientists today. A special, free news feature in Science explores 125 big questions that face scientific inquiry over the next quarter-century; accompanying the feature are several online extras including a reader's forum on the big questions. The Signal Transduction Knowledge Environment highlights some classic Science papers that have influenced the study of cell signaling. The Science of Aging Knowledge Environment looks at several important questions confronting researchers on aging. And Science's Next Wave introduces us to four young scientists building their careers grappling with some of the very questions that Science has identified.

In Science

INTRODUCTION AND OPENING ESSAY

What Don't We Know?
D. Kennedy and C. Norman

In Praise of Hard Questions
T. Siegfried



Online Extras

Be sure to check out these online extras related to our 125th Anniversary Issue:

Your Turn

Did we miss your favorite scientific conundrum? Visit our special online forum to comment on our 125 questions or nominate your own choice.

Anniversary Editorial

Science Editor-in-Chief Donald Kennedy celebrates the magazine's 125th anniversary with some thoughts about Big Questions.

Global Voices

To mark its 125th year of publication, Science has been running a series of essays (each accompanied by an online slide show) providing worldwide perspectives on the scientific enterprise.

First Issues

Registered users of our Web site can take a look at PDF versions of the first two issues of Science, dated 3 July and 10 July 1880.


THE QUESTIONS
The Top 25
Essays by our news staff on 25 big questions facing science over the next quarter-century.
> What Is the Universe Made Of?
> What is the Biological Basis of Consciousness?
> Why Do Humans Have So Few Genes?
> To What Extent Are Genetic Variation and Personal Health Linked?
> Can the Laws of Physics Be Unified?
> How Much Can Human Life Span Be Extended?
> What Controls Organ Regeneration?
> How Can a Skin Cell Become a Nerve Cell?
> How Does a Single Somatic Cell Become a Whole Plant?
> How Does Earth's Interior Work?
> Are We Alone in the Universe?
> How and Where Did Life on Earth Arise?
> What Determines Species Diversity?
> What Genetic Changes Made Us Uniquely Human?
> How Are Memories Stored and Retrieved?
> How Did Cooperative Behavior Evolve?
> How Will Big Pictures Emerge from a Sea of Biological Data?
> How Far Can We Push Chemical Self-Assembly?
> What Are the Limits of Conventional Computing?
> Can We Selectively Shut Off Immune Responses?
> Do Deeper Principles Underlie Quantum Uncertainty and Nonlocality?
> Is an Effective HIV Vaccine Feasible?
> How Hot Will the Greenhouse World Be?
> What Can Replace Cheap Oil -- and When?
> Will Malthus Continue to Be Wrong?

So Much More to Know . . .
A roundup of 100 additional problems that should keep researchers busy for years to come.

[This special news section is being made available free to all visitors to Science Online.]

In STKE

EDITORIAL GUIDE

Signals from the Past
L. B. Ray, E. M. Adler, N. R. Gough
STKE editors provide a small taste of the cell signaling articles published during Science's 125 years.

[Full-text access may require a separate subscription to STKE]

In Science's SAGE KE


PERSPECTIVES

Reactive Oxygen Species and Aging -- Evolving Questions
L. L. Dugan and K. L. Quick
How do ROS contribute to aging in higher organisms?
Metabolomics -- Opening Another Window into Aging
B. S. Kristal and Y. I. Shurubor
What can analysis of the metabolome tell us about aging?
[Full-text access may require a separate subscription to SAGE KE]

In Science's Next Wave

FEATURES

Undisciplined
J. Kling
A cancer researcher finds rapidly evolving genes in a place that in theory should be evolutionarily stable.
Shedding Light on the Dark Side of the Universe
C. Parks
Cosmologist Licia Verde studies dark energy, dark matter, and the evolution of our universe.

Pushing the Boundaries of Science Fiction
E. Pain
Hunting for the genetic basis of disease susceptibility may be a risky career choice, but well worth it.
Finding the Right Response to a Global Invader
A. Forde
Studying natural effective immune responses to HIV may offer insights into a new vaccine strategy.
[Free to all visitors to Science's Next Wave.]