Abstract
Full Text
Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58
Hervé Tettelin, Nigel J. Saunders, John Heidelberg, Alex C. Jeffries, Karen E. Nelson, Jonathan A. Eisen, Karen A. Ketchum, Derek W. Hood, John F. Peden, Robert J. Dodson, William C. Nelson, Michelle L. Gwinn, Robert DeBoy, Jeremy D. Peterson, Erin K. Hickey, Daniel H. Haft, Steven L. Salzberg, Owen White, Robert D. Fleischmann, Brian A. Dougherty, Tanya Mason, Anne Ciecko, Debbie S. Parksey, Eric Blair, Henry Cittone, Emily B. Clark, Matthew D. Cotton, Terry R. Utterback, Hoda Khouri, Haiying Qin, Jessica Vamathevan, John Gill, Vincenzo Scarlato, Vega Masignani, Mariagrazia Pizza, Guido Grandi, Li Sun, Hamilton O. Smith, Claire M. Fraser, E. Richard Moxon, Rino Rappuoli, and J. Craig Venter

Supplementary Material

Amino acid biosynthesis
Aromatic amino acid family
NMB1446 3-dehydroquinate dehydratase (aroD)
NMB1814 3-dehydroquinate Sase (aroB)
NMB1432 3-phosphoshikimate 1-carboxyvinylTase (aroA)
NMB0967 anthranilate PPRTase (trpD)
NMB1021 anthranilate Sase component I (trpE)
NMB1678 aromatic-amino-acid aminoTase (tyrB)
NMB0446 chorismate mutase/prephenate dehydratase (pheA)
NMB1680 chorismate Sase (aroC)
NMB0275 indole-3-glycerol P Sase (trpC)
NMB0688 N-(5'-PPR)anthranilate isomerase (trpF)
NMB0307 phospho-2-dehydro-3-deoxyheptonate aldolase, phe-sensitive (aroG)
NMB0440 prephenate DHase, put ( )
NMB0358 shikimate 5-DHase (aroE)
NMB1813 shikimate kinase (aroK)
NMB0678 tryptophan Sase, alpha sub (trpA)
NMB0699 tryptophan Sase, beta sub (trpB)
Aspartate family
NMB0335 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinylTase (dapD)
NMB0943 5,10-methylenetetrahydrofolate RDase (metF)
NMB0944 5-methyltetrahydropteroyltriglutamate-homocysteine methylTase (metH)
NMB0540 aspartate aminoTase (aspC)
NMB2079 aspartate-semialdehyde DHase (asd)
NMB1498 aspartokinase, alpha and beta subs (lysC)
NMB0802 cystathionine gamma-Sase (metB)
NMB1976 diaminopimelate decarboxylase (lysA)
NMB0760 diaminopimelate epimerase (dapF)
NMB0203 dihydrodipicolinate RDase (dapB)
NMB0929 dihydrodipicolinate Sase (dapA)
NMB1839 formate--tetrahydrofolate ligase (fhs)
NMB1228 homoserine DHase (metM)
NMB2029 homoserine kinase, AFS (thrB)
NMB0940 homoserine O-acetylTase ( )
NMB1530 succinyl-diaminopimelate desuccinylase (dapE)
NMB1046 threonine Sase (thrC)
Glutamate family
NMB1074 acetylglutamate kinase (argB)
NMB1371 acetylornithine aminoTase (argD)
NMB0637 argininosuccinate lyase (argH)
NMB2129 argininosuccinate Sase (argG)
NMB1069 glutamate 5-kinase (proB)
NMB1476 glutamate DHase, NAD-specific (gluD)
NMB1710 glutamate DHase, NADP-specific (gdhA)
NMB2005 glutamate N-acetylTase/amino-acid acetylTase (argJ)
NMB0359 glutamate--NH3 ligase (glnA)
NMB0224 glutamate-NH3-ligase adenylylTase (glnE)
NMB1787 N-acetyl-gamma-glutamyl-P RDase (argC)
NMB1876 N-acetylglutamate Sase (argA)
NMB1995 nitrogen reg prt P-II (glnB)
NMB1573 ornithine carbamoylTase, catabolic (argF)
NMB0055 pyrroline-5-carboxylate RDase (proC)
Pyruvate family
NMB1070 2-isopropylmalate Sase (leuA)
NMB1036 3-isopropylmalate dehydratase, large sub (leuC)
NMB1034 3-isopropylmalate dehydratase, small sub (leuD)
NMB1031 3-isopropylmalate DHase (leuB)
NMB1577 acetolactate Sase III, large sub (ilvI)
NMB1576 acetolactate Sase III, small sub (ilvH)
NMB0337 branched-chain AA aminoTase, put ( )
NMB1150 dihydroxy-acid dehydratase (ilvD-1)
NMB1188 dihydroxy-acid dehydratase (ilvD-2)
NMB1574 ketol-acid reductoisomerase (ilvC)
NMB0878 threonine dehydratase (ilvA)
NMB1823 valine--pyruvate aminoTase (avtA)
Serine family
NMB0381 cys regulon transcriptional activator (cysB)
NMB0763 cysteine Sase (cysK)
NMB1640 phosphoserine aminoTase (serC)
NMB0981 phosphoserine PPase (serB)
NMB0560 serine acetylTase (cysE)
NMB1055 serine hydroxymethylTase (glyA)
Histidine family
NMB0630 amidoTase HisH (hisH)
NMB1579 ATP PPRTase (hisG)
NMB1839 formate--tetrahydrofolate ligase (fhs)
NMB0628 hisF prt (hisF)
NMB1581 histidinol DHase (hisD)
NMB2033 histidinol-PPase, put ( )
NMB1582 histidinol-P aminoTase (hisC)
NMB1583 imidazoleglycerol-P dehydratase (hisB)
NMB0627 PPR-AMP cyclohydrolase (hisI)
NMB0603 PPR-ATP cyclohydrolase (hisE)
NMB0629 PPRformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA)
Purines, pyrimidines, nucleosides, and nucleotides
2'-Deoxyribonucleotide metabolism
NMB0893 deoxyuridine 5`-triP nucleotidohydrolase (dut)
NMB1291 ribonucleoside-diP RDase, alpha sub (nrdA)
NMB1288 ribonucleoside-diP RDase, beta sub (nrdB)
NMB1709 thymidylate Sase (thyA)
Nucleotide and nucleoside interconversions
NMB0823 adenylate kinase (adk)
NMB1300 cytidylate kinase (cmk)
NMB0642 dATP pyrophosphohydrolase (ntpA)
NMB0849 deoxycytidine triP deaminase, put ( )
NMB1661 guanylate kinase (gmk)
NMB1307 nucleoside diP kinase (ndk)
NMB0670 thymidylate kinase (tmk)
NMB2103 uridylate kinase (pyrH)
Purine ribonucleotide biosynthesis
NMB0284 adenylosuccinate lyase (purB)
NMB0815 adenylosuccinate Sase (purA)
NMB0690 amidoPPRTase (purF)
NMB1839 formate--tetrahydrofolate ligase (fhs)
NMB1920 GMP Sase (guaA)
NMB1201 IMP DHase (guaB)
NMB2151 PPRamine--glycine ligase (purD)
NMB1019 PPRaminoimidazole carboxylase, ATPase sub (purK)
NMB1439 PPRaminoimidazole carboxylase, catalytic sub (purE)
NMB0757 PPRaminoimidazole-succinocarboxamide Sase (purC)
NMB0983 PPRaminoimidazolecarboxamide formylTase/IMP cyclohydrolase (purH)
NMB1252 PPRformylglycinamidine cyclo-ligase (purM)
NMB1996 PPRformylglycinamidine Sase (purL)
NMB1566 PPRglycinamide formylTase (purN)
NMB0875 ribose-P pyrophosphokinase (prsA)
Pyrimidine ribonucleotide biosynthesis
NMB0106 aspartate carbamoylTase, catalytic sub (pyrB)
NMB0107 aspartate carbamoylTase, reg sub (pyrI)
NMB1855 carbamoyl-P Sase, large sub (carB)
NMB1849 carbamoyl-P Sase, small sub (carA)
NMB1554 CTP Sase (pyrG)
NMB0682 dihydroorotase (pyrC)
NMB0221 dihydroorotate DHase (pyrD)
NMB1874 orotate PPRTase (pyrE)
NMB0824 orotidine 5`-P decarboxylase (pyrF)
Salvage of nucleosides and nucleotides
NMB1662 adenine PPRTase (apt)
NMB2047 hypoxanthine-guanine PPRTase, put ( )
NMB0774 uracil PPRTase (upp)
Sugar-nucleotide biosynthesis and conversions
NMB0638 UTP--glucose-1-P uridylylTase (galU)
Other
NMB0661 bis(5`-nucleosyl)-tetraPPase, symmetrical/Trk system K+ uptake prt TrkG, fusion ( )
Fatty acid and phospholipid metabolism
Biosynthesis
NMB0179 (3R)-hydroxymyristoyl-(acyl carrier prt) dehydratase (fabZ)
NMB1294 1-acyl-sn-glycerol-3-P acylTase (plsC)
NMB2034 1-acyl-sn-glycerol-3-P acylTase, put ( )
NMB0219 3-oxoacyl-(acyl-carrier-prt) Sase II (fabF-1)
NMB1703 3-oxoacyl-(acyl-carrier-prt) Sase II (fabF-2)
NMB1916 3-oxoacyl-(acyl-carrier-prt) Sase III (fabH)
NMB1860 acetyl-CoA carboxylase, biotin carboxyl carrier prt (accB)
NMB1861 acetyl-CoA carboxylase, biotin carboxylase (accC)
NMB1139 acetyl-CoA carboxylase, carboxyl Tase alpha sub (accA-1)
NMB1177 acetyl-CoA carboxylase, carboxyl Tase alpha sub (accA-2)
NMB0679 acetyl-CoA carboxylase, carboxyl Tase beta sub (accD)
NMB0220 acyl carrier prt (acp-1)
NMB1696 acyl carrier prt (acp-2)
NMB1697 acyl carrier prt, put ( )
NMB1588 CDP-diacylglycerol--glycerol-3-P 3-phosphatidylTase (pgsA)
NMB1318 CDP-diacylglycerol--serine O-phosphatidyltransferse (pssA)
NMB1558 diacylglycerol kinase (dgkA)
NMB0336 enoyl-(acyl-carrier-prt) RDase (fabI)
NMB1913 fatty acid/phospholipid synthesis prt (plsX)
NMB0452 holo-(acyl-carrier prt) Sase (acpS)
NMB1918 malonyl CoA-acyl carrier prt transacylase (fabD)
NMB0185 phosphatidate cytidylylTase (cdsA)
NMB0672 tetraacyldisaccharide 4`-kinase (lpxK)
NMB0180 UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acylTase (lpxD)
Degradation
NMB1921 3-oxoacyl-(acyl-carrier-prt) RDase (fabG-2)
NMB1702 3-oxoacyl-(acyl-carrier-prt) RDase (fabG-1)
NMB1674 GDSL lipase fam prt ( )
NMB1276 long-chain-fatty-acid--CoA ligase (fadD-1)
NMB1555 long-chain-fatty-acid--CoA ligase (fadD-2)
NMB0386 phosphatidylglyceroPPase A (pgpA)
NMB0464 phospholipase A1, put ( )
Biosynthesis of cofactors, prosthetic groups, and carriers
Biotin
NMB0472 8-amino-7-oxononanoate Sase (bioF)
NMB0732 adenosylmethionine-8-amino-7-oxononanoate aminoTase (bioA)
NMB0270 bioH prt, put ( )
NMB0474 biotin synthesis prt BioC, put ( )
NMB1146 biotin Sase (bioB-1)
NMB1184 biotin Sase (bioB-2)
NMB2075 BirA prt/Bvg accessory factor ( )
NMB2075 BirA prt/Bvg accessory factor ( )
NMB0733 dethiobiotin Sase (bioD)
Folic acid
NMB0745 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine-pyrophosphokinase (folK)
NMB0308 dihydrofolate RDase (folA)
NMB1063 dihydroneopterin aldolase (folB)
NMB1691 dihydropteroate Sase (folP)
NMB0694 folI prt (folI)
NMB0693 folylpolyglutamate Sase/dihydrofolate Sase (folC)
NMB2077 methylenetetrahydrofolate DHase/methenyltetrahydrofolate cyclohydrolase, AFS (folD)
NMB0966 para-aminobenzoate Sase glutamine amidoTase component II (pabA)
NMB1970 para-aminobenzoate Sase component I/4-amino-4-deoxychorismate lyase, put (pabB/C)
NMB1055 serine hydroxymethylTase (glyA)
Heme, porphyrin, and cobalamin
NMB0801 delta-aminolevulinic acid dehydratase (hemB)
NMB0718 ferrochelatase (hemH)
NMB1864 glutamate-1-semialdehyde 2,1-aminomutase (hemL)
NMB0576 glutamyl-tRNA RDase (hemA)
NMB0665 oxygen-indep coprophorphyrinogen III oxidase fam prt ( )
NMB0379 oxygen-indep coproporphyrinogen III oxidase (hemN)
NMB0539 porphobilinogen deaminase (hemC)
NMB1194 siroheme Sase (cysG-2)
NMB1156 siroheme Sase (cysG-1)
NMB0778 uroporphyrin-III C-methylTase HemX, put ( )
NMB0781 uroporphyrinogen decarboxylase (hemE)
NMB0777 uroporphyrinogen-III Sase HemD, put ( )
Lipoate
NMB1217 lipoate-prt ligase B (lipB)
NMB1216 lipoic acid Sase (lipA)
Menaquinone and ubiquinone
NMB2030 3-demethylubiquinone-9 3-methylTase (ubiG)
NMB1945 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (ubiX)
NMB0735 4-hydroxybenzoate octaprenylTase (ubiA)
NMB0261 geranyltransTase (ispA)
NMB0326 octaprenyl-diP Sase (ispB)
NMB0323 UbiH fam prt ( )
NMB0559 ubiquinone biosynthesis prt AarF (aarF)
NMB0743 ubiquinone/menaquinone biosynthesis methlyTase UbiE (ubiE)
Molybdopterin
NMB1248 molybdopterin-guanine dinucleotide biosynthesis prt A, AFS (mobA)
Pantothenate and coenzyme A
NMB0870 3-methyl-2-oxobutanoate hydroxymethylTase (panB)
NMB1282 aspartate 1-decarboxylase (panD)
NMB1658 DNA/pantothenate metabolism flavoprt (dfp)
NMB1839 formate--tetrahydrofolate ligase (fhs)
NMB0871 pantoate--beta-alanine ligase (panC)
Pyridoxine
NMB0184 1-deoxy-D-xylulose 5-P reductoisomerase (dxr)
NMB1867 1-deoxyxylulose-5-P Sase (dxs)
NMB1640 phosphoserine aminoTase (serC)
NMB0195 pyridoxal P biosynthetic prt PdxA (pdxA)
NMB0448 pyridoxal P biosynthetic prt PdxJ (pdxJ)
NMB1360 pyridoxamine 5-P oxidase (pdxH)
Riboflavin, FMN, and FAD
NMB1254 GTP cyclohydrolase II (ribA)
NMB1256 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-P Sase (ribA/B)
NMB1834 riboflavin kinase/FMN adenylylTase (ribF)
NMB1247 riboflavin Sase, alpha sub (ribE)
NMB0684 riboflavin Sase, beta sub (ribH)
NMB1817 riboflavin-specific deaminase (ribD)
Glutathione
NMB1057 gamma-glutamyltranspeptidase (ggt)
NMB1037 glutamate--cysteine ligase (gshA)
NMB1559 glutathione Sase (gshB)
Thiamine
NMB0184 1-deoxy-D-xylulose 5-P reductoisomerase (dxr)
NMB1867 1-deoxyxylulose-5-P Sase (dxs)
NMB1616 phosphomethylpyrimidine kinase (thiD)
NMB0385 thiamin-monoP kinase (thiL)
NMB2069 thiamin-P pyrophosphorylase (thiE)
NMB0563 thiamine biosynthesis lipoprt ApbE (apbE)
NMB2040 thiamine biosynthesis prt ThiC (thiC)
NMB2062 thiF prt (thiF)
NMB2071 thiG prt (thiG)
Pyridine nucleotides
NMB0392 l-aspartate oxidase (nadB)
NMB1364 NH(3)-dep NAD+ Sase NadE, put ( )
NMB1505 nicotinate PPRTase (pncB)
NMB0396 nicotinate-nucleotide pyrophosphorylase (nadC)
NMB2157 pyrazinamidase/nicotinamidase PncA, put ( )
NMB0394 quinolinate Sase A (nadA)
Other
NMB0527 6-pyruvoyl tetrahydrobiopterin Sase, put
NMB1168 phytoene Sase, put ( )
NMB1130 phytoene Sase, put ( )
NMB0186 undecaprenyl pyroP Sase (uppS)
Central intermediary metabolism
Amino sugars
NMB0031 glucosamine--fructose-6-P aminoTase (isomerizing) (glmS)
Phosphorus compounds
NMB1467 exopolyPPase (ppx)
NMB0641 inorganic pyroPPase (ppa)
NMB1900 polyP kinase (ppk)
Polyamine biosynthesis
NMB0469 agmatinase (speE)
NMB0468 biosynthetic arginine decarboxylase (speA)
Sulfur metabolism
NMB1155 phosphoadenosine phosphosulfate RDase (cysH-1)
NMB1193 phosphoadenosine phosphosulfate RDase (cysH-2)
NMB1153 sulfate adenylylTase, sub 1 (cysN-1)
NMB1191 sulfate adenylylTase, sub 1 (cysN-2)
NMB1192 sulfate adenylylTase, sub 2 (cysD-2)
NMB1154 sulfate adenylylTase, sub 2 (cysD-1)
NMB1190 sulfite RDase (NADPH) flavoprt, alpha component (cysJ-2)
NMB1152 sulfite RDase (NADPH) flavoprt, alpha component (cysJ-1)
Other
NMB1584 3-hydroxyacid DHase ( )
NMB0767 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase (pfs)
NMB0001 acetylTase, put
NMB1698 acylTase, put
NMB0894 aminoTase, class I ( )
NMB1473 aminoTase, class I ( )
NMB1305 esterase, put
NMB0029 glycerate DHase (hprA)
NMB0605 histone deacetylase fam prt
NMB0040 hydrolase, put ( )
NMB1338 isomerase, put ( )
NMB0331 kinase, put, AFS ( )
NMB0804 NAD(P)H nitroRDase, put ( )
NMB0441 nitrilase ( )
NMB1441 O-methylTase, put ( )
NMB0998 oxidoRDase, put
NMB0614 oxidoRDase, put
NMB1524 oxidoRDase, put ( )
NMB1165 oxidoRDase, short chain DHase/RDase fam ( )
NMB1127 oxidoRDase, short chain DHase/RDase fam ( )
NMB0924 oxidoRDase, short-chain DHase/RDase fam ( )
NMB1391 oxidoRDase, Sol/DevB fam ( )
NMB1799 S-adenosylmethionine Sase (metK)
NMB1462 transglycosylase, put ( )
Energy metabolism
Aerobic
NMB0569 Na(+)-translocating NADH-quinone RDase, sub A (nqrA)
NMB0568 Na(+)-translocating NADH-quinone RDase, sub B (nqrB)
NMB0567 Na(+)-translocating NADH-quinone RDase, sub C (nqrC)
NMB0566 Na(+)-translocating NADH-quinone RDase, sub D (nqrD)
NMB0565 Na(+)-translocating NADH-quinone RDase, sub E (nqrE)
NMB0564 Na(+)-translocating NADH-quinone RDase, sub F (nqrF)
Amino acids and amines
NMB1842 4-hydroxyphenylacetate 3-hydroxylase, small sub, put ( )
NMB1371 acetylornithine aminoTase (argD)
NMB1651 alanine racemase (alr)
NMB1029 aspartate NH3-lyase (aspA)
NMB0176 D-AA DHase, small sub (dadA)
NMB2068 D-AA oxidase flavoprt, put ( )
NMB0575 glycine cleavage system H prt (gcvH)
NMB0574 glycine cleavage system T prt (gcvT)
NMB1676 glycine DHase (decarboxylating), AFS (gcvP)
NMB1688 L-asparaginase I (ansA)
NMB0211 L-serine dehydratase (sdaA)
NMB0206 leucyl/phenylalanyl-tRNA--prt Tase (aat)
NMB1573 ornithine carbamoylTase, catabolic (argF)
NMB0401 proline DHase (putA)
NMB1609 trans-Sation enzyme fam prt ( )
Anaerobic
NMB1622 nitric oxide RDase (norB)
ATP-proton motive force interconversion
NMB1940 ATP Sase F0, A sub (atpB)
NMB1938 ATP Sase F0, B sub (atpF)
NMB1939 ATP Sase F0, C sub (atpE)
NMB1936 ATP Sase F1, alpha sub (atpA)
NMB1934 ATP Sase F1, beta sub (atpD)
NMB1937 ATP Sase F1, delta sub (atpH)
NMB1933 ATP Sase F1, epsilon sub (atpC)
NMB1935 ATP Sase F1, gamma sub (atpG)
Electron transport
NMB0923 cytochrome c ( )
NMB1725 cytochrome c oxidase, sub I (fixN)
NMB1724 cytochrome c oxidase, sub II (fixO)
NMB1723 cytochrome c oxidase, sub III (fixP)
NMB1803 cytochrome c-type biogenesis prt, put ( )
NMB1804 cytochrome c-type biogenesis prt, put ( )
NMB1805 cytochrome c4 ( )
NMB1677 cytochrome c5
NMB1722 cytochrome C555, truncation ( )
NMB0717 cytochrome, put ( )
NMB2154 electron transfer flavoprt, alpha sub (etfA)
NMB2155 electron transfer flavoprt, beta sub (etfB)
NMB0581 electron transfer flavoprt-ubiquinone oxidoRDase
NMB1172 ferredoxin, 2Fe-2S type (fdx-2)
NMB1134 ferredoxin, 2Fe-2S type (fdx-1)
NMB0208 ferredoxin, 4Fe-4S bacterial type ( )
NMB0123 ferredoxin, 4Fe-4S bacterial type ( )
NMB1454 ferredoxin, 4Fe-4S bacterial type ( )
NMB1287 ferredoxin, put
NMB1450 ferredoxin--NADP RDase (fpr-2)
NMB1044 ferredoxin--NADP RDase (fpr-1)
NMB1734 glutaredoxin (grx)
NMB1790 glutaredoxin 3 (grxC)
NMB0569 Na(+)-translocating NADH-quinone RDase, sub A (nqrA)
NMB0568 Na(+)-translocating NADH-quinone RDase, sub B (nqrB)
NMB0567 Na(+)-translocating NADH-quinone RDase, sub C (nqrC)
NMB0566 Na(+)-translocating NADH-quinone RDase, sub D (nqrD)
NMB0565 Na(+)-translocating NADH-quinone RDase, sub E (nqrE)
NMB0564 Na(+)-translocating NADH-quinone RDase, sub F (nqrF)
NMB0980 NAD(P) transhydrogenase, alpha sub (pntA)
NMB0978 NAD(P) transhydrogenase, beta sub (pntB)
NMB0241 NADH DHase I, A sub (nuoA)
NMB0242 NADH DHase I, B sub (nuoB)
NMB0243 NADH DHase I, C sub (nuoC)
NMB0244 NADH DHase I, D sub (nuoD)
NMB0245 NADH DHase I, E sub (nuoE)
NMB0246 NADH DHase I, F sub (nuoF)
NMB0249 NADH DHase I, G sub (nuoG)
NMB0250 NADH DHase I, H sub (nuoH)
NMB0251 NADH DHase I, I sub (nuoI)
NMB0253 NADH DHase I, J sub (nuoJ)
NMB0254 NADH DHase I, K sub (nuoK)
NMB0257 NADH DHase I, L sub (nuoL)
NMB0258 NADH DHase I, M sub (nuoM)
NMB0259 NADH DHase I, N sub (nuoN)
NMB1158 nickel-dep hydrogenase, b-type cytochrome sub ( )
NMB1196 nickel-dep hydrogenase, b-type cytochrome sub ( )
NMB0993 rubredoxin ( )
NMB1845 thioredoxin ( )
NMB1366 thioredoxin ( )
NMB1324 thioredoxin RDase (trxB)
NMB1958 thioredoxin, put ( )
NMB2052 ubiquinol--cytochrome c RDase, cytochrome b (petB)
NMB2051 ubiquinol--cytochrome c RDase, cytochrome c1 (petC)
NMB2053 ubiquinol--cytochrome c RDase, Fe-S sub (petA)
Entner-Doudoroff
NMB1394 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase (eda)
NMB1393 phosphogluconate dehydratase (edd)
Fermentation
NMB0435 acetate kinase (ackA-1)
NMB1518 acetate kinase (ackA-2)
NMB1304 alcohol DHase, class III
NMB0546 alcohol DHase, propanol-preferring (adhP)
NMB0604 alcohol DHase, Zn-containing
NMB1395 alcohol DHase, Zn-containing ( )
NMB1968 aldehyde DHase A (aldA)
NMB1353 aldehyde DHase fam prt ( )
NMB0430 carboxyphosphonoenolpyruvate phosphonomutase, put ( )
NMB1685 D-lactate DHase (ldhA)
NMB0431 methylcitrate Sase/citrate Sase 2 (pprC)
NMB0631 P acetylTase Pta, put ( )
Glycolysis/gluconeogenesis
NMB0997 D-lactate DHase (dld)
NMB1285 enolase (eno)
NMB1060 fructose-1,6-bisPPase (fbp)
NMB1869 fructose-bisP aldolase (cbbA)
NMB1390 glucokinase (glk)
NMB0334 glucose-6-P isomerase (pgi-1)
NMB1388 glucose-6-P isomerase (pgi-2)
NMB0207 glyceraldehyde 3-P DHase (gapA-1)
NMB2159 glyceraldehyde 3-P DHase (gapA-2)
NMB0618 phosphoenolpyruvate Sase (ppsA)
NMB0010 phosphoglycerate kinase (pgk)
NMB1604 phosphoglycerate mutase (gpm)
NMB0089 pyruvate kinase II (pykA)
NMB1887 trioseP isomerase (tpiA)
Pentose phosphate pathway
NMB0015 6-phosphogluconate DHase, decarboxylating (gnd)
NMB1392 glucose-6-P 1-DHase (zwf)
NMB1511 ribose 5-P isomerase A (rpiA)
NMB1244 ribulose-P 3-epimerase (rpe)
NMB0351 transaldolase (tal)
NMB1457 transketolase (tktA)
Pyruvate dehydrogenase
NMB1341 pyruvate DHase, E1 component (pdhA)
NMB1342 pyruvate DHase, E2 component, dihydrolipoamide acetylTase (aceF)
NMB1344 pyruvate DHase, E3 component, lipoamide DHase (lpdA)
Sugars
NMB0389 aldose 1-epimerase (galM)
NMB0391 beta-phosphoglucomutase (pgmB)
NMB0390 maltose phosphorylase (mapA)
NMB0790 phosphoglucomutase (pgm)
NMB1690 phosphoglucomutase/phosphomannomutase fam prt (mrsA)
NMB0620 phosphoglycolate PPase (pgp)
NMB1478 phosphoglycolate PPase, AFS (gph)
NMB1830 phosphoglycolate PPase, put ( )
NMB0352 sugar isomerase, KpsF/GutQ fam ( )
NMB2028 thermoresistant gluconokinase (gntK)
NMB0064 UDP-glucose 4-epimerase (galE)
NMB0078 UDP-glucose 4-epimerase, truncation ( )
TCA cycle
NMB0955 2-oxoglutarate DHase, E1 component (sucA)
NMB0956 2-oxoglutarate DHase, E2 component, dihydrolipoamide succinylTase (sucB)
NMB0957 2-oxoglutarate DHase, E3 component, lipoamide DHase (lpd)
NMB0433 aconitate hydratase 1 (acnA)
NMB1572 aconitate hydratase 2 (acnB)
NMB0954 citrate Sase (gltA)
NMB1613 fumarate hydratase, class I (fumB)
NMB1458 fumarate hydratase, class II (fumC)
NMB0920 isocitrate DHase (icd)
NMB0947 lipoamide DHase, put ( )
NMB2096 malate:quinone oxidoRDase (yojH)
NMB0431 methylcitrate Sase/citrate Sase 2 (pprC)
NMB0948 succinate DHase, cytochrome b556 sub (sdhC)
NMB0950 succinate DHase, flavoprt sub (sdhA)
NMB0949 succinate DHase, hydrophobic membrane anchor prt (sdhD)
NMB0951 succinate DHase, Fe-S prt (sdhB)
NMB0960 succinyl-CoA Sase, alpha sub (sucD)
NMB0959 succinyl-CoA Sase, beta sub (sucC)
Biosynthesis and degradation of polysaccharides
NMB0530 glycosyl hydrolase, fam 3
Other
NMB1474 4-oxalocrotonate tautomerase, put ( )
NMB1493 carbon starvation prt A (cstA)
NMB1997 hydroxyacylglutathione hydrolase (hagH)
NMB0340 lactoylglutathione lyase (gloA)
NMB0671 malate oxidoRDase (NAD) (sfcA)
NMB2061 phosphoenolpyruvate carboxylase (ppc)
NMB1488 succinate-semialdehyde DHase (NADP+) (gabD)
Transport and binding proteins
Amino acids, peptides and amines
NMB0789 AA ABC transp, ATP-Bprt ( )
NMB0696 AA ABC transp, ATP-Bprt ( )
NMB0787 AA ABC transp, periplasmic AA-Bprt ( )
NMB1612 AA ABC transp, periplasmic AA-Bprt ( )
NMB0788 AA ABC transp, permease prt ( )
NMB1509 AA ABC transp, permease prt ( )
NMB1647 AA symporter, put ( )
NMB0194 AA symporter, put ( )
NMB2136 peptide transp ( )
NMB0177 Na+/alanine symporter, put ( )
NMB0085 Na+/glutamate symporter (gltS)
NMB0402 Na+/proline symporter (putP)
NMB0610 spermidine/putrescine ABC transp, ATP-Bprt (potA-1)
NMB2042 spermidine/putrescine ABC transp, ATP-Bprt (potA-2)
NMB0462 spermidine/putrescine ABC transp, periplasmic spermidine/putrescine-Bprt (potD-1)
NMB1594 spermidine/putrescine ABC transp, periplasmic spermidine/putrescine-Bprt (potD-3)
NMB0623 spermidine/putrescine ABC transp, periplasmic spermidine/putrescine-Bprt (potD-2)
NMB0612 spermidine/putrescine ABC transp, permease prt (potC)
NMB0611 spermidine/putrescine ABC transp, permease prt (potB)
NMB2031 tryptophan transp (mtr)
Anions
NMB0378 P permease, put ( )
NMB0879 sulfate ABC transp, ATP-Bprt (cysA)
NMB1017 sulfate ABC transp, periplasmic sulfate-Bprt (sbp)
NMB0881 sulfate ABC transp, permease prt (cysT)
NMB0880 sulfate ABC transp, permease prt (cysW)
Carbohydrates, organic alcohols, and acids
NMB0470 C4-dicarboxylate transp ( )
NMB0074 capsule polysaccharide export ATP-Bprt CtrD (ctrD)
NMB0072 capsule polysaccharide export inner-membrane prt CtrB (ctrB)
NMB0073 capsule polysaccharide export inner-membrane prt CtrC (ctrC)
NMB0071 capsule polysaccharide export outer membrane prt CtrA (ctrA)
NMB1794 citrate transp ( )
NMB2027 gluconate permease (gntP)
NMB0535 glucose/galactose transp (gluP)
NMB0543 L-lactate permease, put
NMB1362 oxalate/formate antiporter, put ( )
NMB2045 phosphocarrier prt HPr (ptsH)
NMB2044 phosphoenolpyruvate-prt phosphoTase (ptsI)
NMB2046 PTS system, IIAB component ( )
NMB2133 Na+/dicarboxylate symporter fam prt ( )
NMB0388 sugar transp, put ( )
Cations
NMB0615 NH4+ transp AmtB, put ( )
NMB1207 bacterioferritin A (bfrA)
NMB1206 bacterioferritin B (bfrB)
NMB0752 bacterioferritin-associated ferredoxin, put ( )
NMB0661 bis(5`-nucleosyl)-tetraPPase, symmetrical/Trk system K+ uptake prt TrkG, fusion ( )
NMB1325 cation transport ATPase, E1-E2 fam ( )
NMB1042 cation transport ATPase, E1-E2 fam ( )
NMB0579 copper ABC transp, ATP-Bprt (nosF)
NMB0578 copper ABC transp, periplasmic copper-Bprt (nosD)
NMB0209 glutathione-regulated K+-efflux system prt (kefB)
NMB1668 hemoglobin receptor (hmbR)
NMB1993 iron(III) ABC transp, ATP-Bprt ( )
NMB0632 iron(III) ABC transp, ATP-Bprt, AFS (fbpC)
NMB1989 iron(III) ABC transp, periplasmic Bprt ( )
NMB0634 iron(III) ABC transp, periplasmic Bprt (fbpA)
NMB1990 iron(III) ABC transp, permease prt ( )
NMB1991 iron(III) ABC transp, permease prt ( )
NMB0633 iron(III) ABC transp, permease prt, AFS (fbpB)
NMB1988 Fe-regulated outer membrane prt FrpB (frpB)
NMB1540 lactoferrin-Bprt A (lbpA)
NMB1541 lactoferrin-Bprt B (lbpB)
NMB1999 Mg2+ transp (mgtE)
NMB1271 mercury transport periplasmic prt, put ( )
NMB0536 Na+/H+ antiporter
NMB1730 TonB prt (tonB)
NMB1829 TonB-dep receptor ( )
NMB1882 TonB-dep receptor ( )
NMB1497 TonB-dep receptor ( )
NMB1449 TonB-dep receptor, APM ( )
NMB0293 TonB-dep receptor, put ( )
NMB1346 TonB-dep receptor, put, AFS ( )
NMB0461 transferrin-Bprt 1 (tbp1)
NMB0460 transferrin-Bprt 2 (tbp2)
NMB1614 Trk system K+ uptake prt TrkA (trkA)
Nucleosides, purines and pyrimidines
NMB1315 uracil permease (uraA)
NMB0930 xanthine/uracil permease fam prt ( )
Porins
NMB2039 major outer membrane prt PIB (porB)
NMB1429 outer membrane prt PorA (porA)
Other
NMB0445 bicyclomycin resistance prt, put ( )
NMB1729 biopolymer transport prt ExbB (exbB)
NMB1728 biopolymer transport prt ExbD (exbD)
NMB1435 drug resistance translocase fam prt ( )
NMB1461 drug resistance translocase fam prt ( )
NMB0318 fatty acid efflux system prt (farA)
NMB0319 fatty acid efflux system prt (farB)
NMB1716 membrane fusion prt (mtrC)
NMB1714 multidrug efflux pump channel prt (mtrE)
NMB0393 multidrug resistance prt ( )
NMB1715 multiple transferable resistance system prt MtrD (mtrD)
NMB0736 PTS system, nitrogen reg IIA prt (ptsN)
NMB1738 secretion prt, put ( )
NMB1783 secretion prt, put, AFS ( )
NMB0097 secretion prt, put, degenerate ( )
NMB1277 transp, BCCT fam ( )
Unknown substrate
NMB1400 ABC transp fam prt ( )
NMB1919 ABC transp, ATP-Bprt ( )
NMB1948 ABC transp, ATP-Bprt ( )
NMB1226 ABC transp, ATP-Bprt ( )
NMB1240 ABC transp, ATP-Bprt ( )
NMB0356 ABC transp, ATP-Bprt ( )
NMB0588 ABC transp, ATP-Bprt
NMB0549 ABC transp, ATP-Bprt (ybjZ)
NMB0387 ABC transp, ATP-Bprt ( )
NMB1966 ABC transp, ATP-Bprt ( )
NMB1234 ABC transp, ATP-Bprt ( )
NMB0264 ABC transp, ATP-Bprt ( )
NMB1051 ABC transp, ATP-Bprt ( )
NMB1122 ABC transp, ATP-Bprt AFS ( )
NMB0098 ABC transp, ATP-Bprt, AFS ( )
NMB0523 ABC transp, ATP-Bprt, truncation
NMB1077 ABC transp, ATP-Bprt, truncation ( )
NMB0041 ABC transp, periplasmic solute-Bprt ( )
NMB1880 ABC transp, periplasmic solute-Bprt, put ( )
NMB1947 ABC transp, permease prt ( )
NMB2026 ABC transp, permease prt ( )
NMB1707 Na+- and Cl--dep transp ( )
NMB1975 Na+- and Cl--dep transp ( )
NMB1299 Na+- and Cl--dep transp, degenerate
NMB0705 transp ( )
NMB0792 transp, NadC fam ( )
NMB1515 transp, put ( )
NMB1219 transp, put ( )
NMB1732 transp, put ( )
DNA metabolism
DNA replication, recombination, and repair
NMB1396 A/G-specific adenine glycosylase (mutY)
NMB1447 ATP-dep DNA helicase (rep)
NMB1788 ATP-dep DNA helicase RecG (recG)
NMB0274 ATP-dep DNA helicase RecQ (recQ)
NMB0826 C-5 cytosine-specific DNA methylase ( )
NMB1903 chromosomal replication initiator prt DnaA (dnaA)
NMB1419 crossover junction endodeoxyribonuclease RuvC (ruvC)
NMB0289 deoxyribodipyrimidine photolyase, AFS (phrB)
NMB1384 DNA gyrase sub A (gyrA)
NMB0212 DNA gyrase sub B (gyrB)
NMB0232 DNA helicase II (uvrD)
NMB0494 DNA helicase, truncation ( )
NMB0666 DNA ligase (ligA-1)
NMB2048 DNA ligase (ligA-2)
NMB2160 DNA mismatch repair prt MutS (mutS)
NMB1568 DNA polymerase holoenzyme chi sub, put ( )
NMB1982 DNA polymerase I (polA)
NMB1827 DNA polymerase III, alpha sub (dnaE)
NMB1902 DNA polymerase III, beta sub (dnaN)
NMB0769 DNA polymerase III, delta prime sub, put ( )
NMB0708 DNA polymerase III, delta sub (holA)
NMB1514 DNA polymerase III, epsilon sub (dnaQ-2)
NMB1451 DNA polymerase III, epsilon sub (dnaQ-1)
NMB1443 DNA polymerase III, subs gamma and tau, programmed frameshift (dnaX)
NMB1873 DNA polymerase, bacteriophage-type, put
NMB1537 DNA primase (dnaG)
NMB0782 DNA repair prt RadA (radA)
NMB1038 DNA repair prt RadC (radC)
NMB0740 DNA repair prt RecN (recN)
NMB0447 DNA repair prt RecO (recO)
NMB0118 DNA topoisomerase I (topA)
NMB1673 DNA-3-methyladenine glycosylase I (tag)
NMB1658 DNA/pantothenate metabolism flavoprt (dfp)
NMB0056 DnaK suppressor prt (dksA)
NMB0533 endonuclease III (nth)
NMB0962 excinuclease ABC, sub A (uvrA)
NMB1331 excinuclease ABC, sub B (uvrB)
NMB1326 excinuclease ABC, sub C (uvrC)
NMB2082 exodeoxyribonuclease (exoA)
NMB0399 exodeoxyribonuclease III (xthA)
NMB1720 exodeoxyribonuclease V 125 kD polypeptide (recC)
NMB0785 exodeoxyribonuclease V 135 KD polypeptide (recB)
NMB1233 exodeoxyribonuclease V, alpha sub (recD)
NMB1420 factor-for-inversion stimulation prt Fis, put ( )
NMB1295 formamidopyrimidine-DNA glycosylase (mutM)
NMB0265 Holliday junction DNA helicase RuvA (ruvA)
NMB1243 Holliday junction DNA helicase RuvB (ruvB)
NMB1868 integrase/recombinase XerC (xerC)
NMB0751 integrase/recombinase XerD (xerD)
NMB0729 integration host factor, alpha sub (himA)
NMB1302 integration host factor, beta sub (himD)
NMB1528 methylated-DNA--prt-cysteine methylTase, put
NMB1442 mismatch repair prt MutL (mutL)
NMB0453 mutT prt (mutT)
NMB1683 MutT/nudix fam prt ( )
NMB1552 pilin gene inverting prt PivNM-1A (pivNM-1A)
NMB1625 pilin gene inverting prt PivNM-1B (pivNM-1B)
NMB1750 pilin gene inverting prt PivNM-2 (pivNM-2)
NMB0551 primosomal prt n` (priA)
NMB1322 primosomal replication prt n, put
NMB0287 probable ATP-dep helicase DinG (dinG)
NMB1445 recA prt (recA)
NMB0851 recombination associated prt RdgC (rdgC)
NMB1237 recombination prt RecR (recR)
NMB1479 reg prt RecX (recX)
NMB0885 replicative DNA helicase (dnaB)
NMB1460 single-strand Bprt (ssb)
NMB0842 single-stranded-DNA-specific exonuclease RecJ (recJ)
NMB1278 site-specific recombinase (gcr)
NMB1605 topoisomerase IV sub A (parC)
NMB1682 topoisomerase IV sub B (parE)
NMB1281 transcription-repair coupling factor (mfd)
NMB1222 uracil-DNA glycosylase (ung)
Restriction/modification
NMB1655 adenine specific methylase, put ( )
NMB1290 C-5 cytosine-specific DNA-methylase ( )
NMB1895 DNA adenine methylase, truncation ( )
NMB2065 hemK prt (hemK)
NMB0076 methylTase HphIm(C), AFS ( )
NMB0725 modification methylase HgaI-1 ( )
NMB1033 modification methylase NlaIV ( )
NMB1375 modification methylase, put, AFS ( )
NMB0727 N-6 adenine-specific DNA methylase ( )
NMB1257 site-specific DNA methylase, degenerate ( )
NMB0210 site-specific DNA methylase, truncation ( )
NMB0077 site-specific DNA methylase, truncation ( )
NMB0829 type I restriction enzyme EcoR124II M prt (hsdM)
NMB0835 type I restriction enzyme EcoR124II R prt, put ( )
NMB0831 type I restriction enzyme S prt, degenerate ( )
NMB1896 type II restriction enzyme DpnI (dpnC)
NMB0726 type II restriction enzyme HgaI ( )
NMB1032 type II restriction enzyme NlaIV (nlaIVR)
NMB1289 type II restriction enzyme, put ( )
NMB1261 type III restriction-modification system EcoPI enzyme, sub mod, APM (mod)
NMB1260 type III restriction-modification system EcoPI enzyme, sub res (res)
Degradation of DNA
NMB1363 exodeoxyribonuclease, large sub (xseA)
NMB0262 exodeoxyribonuclease, small sub (xseB)
NMB1510 thermonuclease fam prt ( )
Transcription
Degradation of RNA
NMB1863 oligoribonuclease (orn)
NMB0758 polyribonucleotide nucleotidylTase (pnp)
NMB1618 ribonuclease HI (rnhA)
NMB0192 ribonuclease HII (rnhB)
NMB1200 ribonuclease II fam prt (vacB)
NMB0646 ribonuclease inhibitor barstar ( )
NMB0662 ribonuclease, put ( )
DNA-dependent RNA polymerase
NMB0168 DNA-directed RNA polymerase, alpha sub (rpoA)
NMB0132 DNA-directed RNA polymerase, beta sub (rpoB)
NMB0133 DNA-directed RNA polymerase, beta' sub (rpoC)
NMB1660 DNA-directed RNA polymerase, omega sub (rpoZ)
Transcription factors
NMB1368 ATP-dep RNA helicase, put ( )
NMB1422 ATP-dep RNA helicase, put ( )
NMB1642 N utilization substance prt A (nusA)
NMB0683 N utilization substance prt B (nusB)
NMB1538 RNA polymerase sigma factor RpoD (rpoD)
NMB0712 RNA polymerase sigma-32 factor (rpoH)
NMB0217 RNA polymerase sigma-54 factor RpoN, put ( )
NMB2144 sigma factor, put ( )
NMB0126 transcription antiterm prt NusG (nusG)
NMB1430 transcription elong factor GreA (greA)
NMB0689 transcription elong factor GreB (greB)
NMB0617 transcription term factor Rho (rho)
NMB0075 transcriptional accessory prt Tex, put ( )
RNA processing
NMB0591 16S rRNA processing prt RimM (rimM)
NMB0832 anticodon nuclease (prrC)
NMB0843 polyA polymerase (pcnB)
NMB0196 ribonuclease E (rne)
NMB0686 ribonuclease III (rnc)
NMB1905 ribonuclease P prt component (rnpA)
NMB1499 ribonuclease PH (rph)
NMB1373 ribosome-binding factor A (rbfA)
NMB1241 tRNA nucleotidylTase (cca)
Other
NMB2009 ATP-dep RNA helicase HrpA, degenerate ( )
NMB2007 ATP-dep RNA helicase HrpA, truncation ( )
NMB2011 ATP-dep RNA helicase HrpA, truncation ( )
Protein synthesis
tRNA aminoacylation
NMB1595 alanyl-tRNA Sase (alaS)
NMB1506 arginyl-tRNA Sase (argS)
NMB0466 aspartyl-tRNA Sase (aspS)
NMB2083 cysteinyl-tRNA Sase (cysS)
NMB1839 formate--tetrahydrofolate ligase (fhs)
NMB1356 Glu-tRNA(Gln) amidoTase, sub A (gatA)
NMB1358 Glu-tRNA(Gln) amidoTase, sub B (gatB)
NMB1560 glutaminyl-tRNA Sase (glnS)
NMB1355 glutamyl-tRNA (Gln) amidoTase sub C, put (gatC)
NMB0003 glutamyl-tRNA Sase (gltX)
NMB1932 glycyl-tRNA Sase, alpha chain (glyQ)
NMB1930 glycyl-tRNA Sase, beta chain (glyS)
NMB0814 histidyl-tRNA Sase (hisS-1)
NMB0854 histidyl-tRNA Sase (hisS-2)
NMB1833 isoleucyl-tRNA Sase (ileS)
NMB1897 leucyl-tRNA Sase (leuS)
NMB1425 lysyl-tRNA Sase, heat inducible (lysU)
NMB0111 methionyl-tRNA formylTase (fmt)
NMB0030 methionyl-tRNA Sase (metG)
NMB0724 phenylalanyl-tRNA Sase, alpha chain (pheS)
NMB0728 phenylalanyl-tRNA Sase, beta chain (pheT)
NMB1339 prolyl-tRNA Sase (proS)
NMB0719 queuine tRNA-ribosylTase (tgt)
NMB1684 seryl-tRNA Sase (serS)
NMB0720 threonyl-tRNA Sase (thrS)
NMB1471 tryptophanyl-tRNA Sase (trpS)
NMB1835 tyrosyl-tRNA Sase (tyrS)
NMB0174 valyl-tRNA Sase (valS)
Nucleoproteins
NMB1230 DNA-Bprt HU-beta (hupB)
NMB0729 integration host factor, alpha sub (himA)
NMB1302 integration host factor, beta sub (himD)
Ribosomal proteins: synthesis and modification
NMB1301 30S ribosomal prt S1 (rpsA)
NMB0140 30S ribosomal prt S10 (rpsJ)
NMB0166 30S ribosomal prt S11 (rpsK)
NMB0136 30S ribosomal prt S12 (rpsL)
NMB0165 30S ribosomal prt S13 (rpsM)
NMB0155 30S ribosomal prt S14 (rpsN)
NMB0609 30s ribosomal prt S15 (rpsO)
NMB0592 30S ribosomal prt S16 (rpsP)
NMB0151 30S ribosomal prt S17 (rpsQ)
NMB1321 30S ribosomal prt S18 (rpsR)
NMB0146 30S ribosomal prt S19 (rpsS)
NMB2101 30S ribosomal prt S2 (rpsB)
NMB0463 30S ribosomal prt S20 (rpsT)
NMB1950 30S ribosomal prt S21 (rpsU)
NMB0148 30S ribosomal prt S3 (rpsC)
NMB0167 30S ribosomal prt S4 (rpsD)
NMB0159 30s ribosomal prt S5 (rpsE)
NMB1323 30S ribosomal prt S6 (rpsF)
NMB0137 30S ribosomal prt S7 (rpsG)
NMB0156 30S ribosomal prt S8 (rpsH)
NMB2056 30S ribosomal prt S9 (rpsI)
NMB0128 50S ribosomal prt L1 (rplA)
NMB0130 50S ribosomal prt L10 (rplJ)
NMB0127 50S ribosomal prt L11 (rplK)
NMB2057 50S ribosomal prt L13 (rplM)
NMB0152 50S ribosomal prt L14 (rplN)
NMB0161 50S ribosomal prt L15 (rplO)
NMB0149 50S ribosomal prt L16 (rplP)
NMB0169 50S ribosomal prt L17 (rplQ)
NMB0158 50S ribosomal prt L18 (rplR)
NMB0589 50s ribosomal prt L19 (rplS)
NMB0145 50S ribosomal prt L2 (rplB)
NMB0723 50S ribosomal prt L20 (rplT)
NMB0325 50S ribosomal prt L21 (rplU)
NMB0147 50S ribosomal prt L22 (rplV)
NMB0144 50S ribosomal prt L23 (rplW)
NMB0153 50S ribosomal prt L24 (rplX)
NMB0876 50S ribosomal prt L25 (rplY)
NMB0324 50S ribosomal prt L27 (rpmA)
NMB0321 50S ribosomal prt L28 (rpmB)
NMB0150 50S ribosomal prt L29 (rpmC)
NMB0142 50S ribosomal prt L3 (rplC)
NMB0160 50S ribosomal prt L30 (rpmD)
NMB1956 50S ribosomal prt L31 (rpmE)
NMB0942 50S ribosomal prt L31, put (rpmE)
NMB1911 50S ribosomal prt L32 (rpmF)
NMB0322 50S ribosomal prt L33 (rpmG)
NMB1904 50S ribosomal prt L34 (rpmH)
NMB0722 50S ribosomal prt L35 (rpmI)
NMB0941 50S ribosomal prt L36 (rpmJ)
NMB0143 50S ribosomal prt L4 (rplD)
NMB0154 50S ribosomal prt L5 (rplE)
NMB0157 50S ribosomal prt L6 (rplF)
NMB0131 50S ribosomal prt L7/L12 (rplL)
NMB1320 50S ribosomal prt L9 (rplI)
NMB1862 ribosomal prt L11 methylTase (prmA)
NMB1872 ribosomal-prt-alanine acetylTase, put ( )
tRNA and rRNA base modification
NMB0112 16S RNA methylTase (rsmB)
NMB0697 dimethyladenosine Tase (ksgA)
NMB1351 fmu and fmv prt, put ( )
NMB0524 ribonuclease BN, put
NMB0198 ribosomal large sub pseudouridine Sase C (rluC)
NMB0704 ribosomal large sub pseudouridine Sase D (rluD)
NMB1298 ribosomal small sub pseudouridine Sase A (rsuA)
NMB1348 RNA methylase, put ( )
NMB0268 RNA methylTase, TrmH fam ( )
NMB0931 RNA methylTase, TrmH fam ( )
NMB1179 RNA methylTase, TrmH fam ( )
NMB1141 RNA methylTase, TrmH fam ( )
NMB0066 rRNA adenine N-6-methylTase (ermC)
NMB1859 S-adenosylmethionine:tRNA ribosylTase-isomerase (queA)
NMB1556 tRNA (5-methylaminomethyl-2-thiouridylate)-methylTase (trmU)
NMB0590 tRNA (guanine-N1)-methylTase (trmD)
NMB1679 tRNA (uracil-5-)-methylTase (trmA)
NMB0935 tRNA delta(2)-isopentenylpyroP Tase (miaA)
NMB2036 tRNA pseudouridine Sase A (truA)
NMB1374 tRNA pseudouridine Sase B (truB)
Translation factors
NMB0138 elong factor G (EF-G) (fusA)
NMB0937 elong factor P (EF-P) (efp)
NMB2102 elong factor TS (EF-TS) (tsf)
NMB1686 peptide chain release factor 1 (prfA)
NMB2138 peptide chain release factor 2 (prfB)
NMB0626 peptide chain release factor 3 (prfC)
NMB0187 ribosome recycling factor (frr)
NMB0124 translation elong factor Tu (tufB)
NMB0139 translation elong factor Tu (tufA)
NMB0721 translation init factor 3 (infC)
NMB0163 translation init factor IF-1 (infA)
NMB1643 translation init factor IF-2 (infB)
Other
NMB0795 peptidyl-tRNA hydrolase (pth)
Protein fate
Protein and peptide secretion and trafficking
NMB1832 lipoprt signal peptidase (lspA)
NMB0622 outer membrane lipoprt carrier prt (lolA)
NMB1536 preprt translocase SecA sub (secA)
NMB0162 preprt translocase SecY sub (secY)
NMB0125 preprt translocase SecE sub (secE)
NMB0607 prt-export membrane prt SecD (secD)
NMB0608 prt-export membrane prt SecF (secF)
NMB1888 prt-export membrane prt SecG (secG)
NMB1789 prt-export prt SecB (secB)
NMB1737 secretion prt, put ( )
NMB0765 signal peptidase I (lepB)
NMB0295 signal recognition particle prt (ffh)
NMB0045 signal recognition particle prt (pilA)
NMB1313 trigger factor (tig)
Protein modification and repair
NMB0922 alpha-2,3-sialylTase ( )
NMB0713 apolipoprt N-acylTase, put ( )
NMB1649 disulfide bond formation prt B (dsbB)
NMB0218 glycosylTase (pglA)
NMB2093 methionine aminopeptidase (map)
NMB0044 peptide methionine sulfoxide RDase (pilB)
NMB1820 pilin glycosylation prt PglB (pglB)
NMB1821 pilin glycosylation prt PglC (pglC)
NMB1822 pilin glycosylation prt PglD (pglD)
NMB0110 polypeptide deformylase (def)
NMB1072 prolipoprt diacylglyceryl Tase (lgt)
NMB1885 prt-L-isoaspartate O-methylTase (pcm)
Protein folding and stabilization
NMB1131 chaperone prt HscA (hscA-1)
NMB1169 chaperone prt HscA (hscA-2)
NMB1973 chaperonin, 10 kDa (groES)
NMB1972 chaperonin, 60 kDa (groEL)
NMB0059 dnaJ prt (dnaJ)
NMB1027 dnaJ prt, truncation ( )
NMB0554 dnaK prt (dnaK)
NMB0027 FKBP-type peptidyl-prolyl cis-trans isomerase (fbp)
NMB1522 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (slyD)
NMB0561 grpE prt (grpE)
NMB0822 heat shock prt HtpX (htpX)
NMB0281 peptidyl-prolyl cis-trans isomerase ( )
NMB1262 peptidyl-prolyl cis-trans isomerase ( )
NMB0791 peptidyl-prolyl cis-trans isomerase ( )
NMB0580 prt disulfide isomerase NosL, put
NMB0294 thiol:disulfide interchange prt DsbA (dsbA-2)
NMB0407 thiol:disulfide interchange prt DsbA (dsbA-3)
NMB0278 thiol:disulfide interchange prt DsbA (dsbA-1)
NMB0550 thiol:disulfide interchange prt DsbC (dsbC)
NMB1519 thiol:disulfide interchange prt DsbD (dsbD)
NMB1313 trigger factor (tig)
Degradation of proteins, peptides, and glycopeptides
NMB1569 aminopeptidase A/I, AFS (pepA)
NMB1416 aminopeptidase N (pepN)
NMB1428 aminopeptidase, put ( )
NMB0836 ATP-dep Clp protease, ATP-binding sub ClpA (clpA)
NMB1372 ATP-dep Clp protease, ATP-binding sub ClpX (clpX)
NMB1312 ATP-dep Clp protease, proteolytic sub (clpP)
NMB1231 ATP-dep protease La (lon)
NMB1332 carboxy-terminal peptidase (prc)
NMB1472 clpB prt (clpB)
NMB0700 IgA-specific serine endopeptidase (iga)
NMB1802 O-sialoglycoprt endopeptidase (gcp)
NMB0214 oligopeptidase A (prlC)
NMB0927 proline iminopeptidase (pip)
NMB1877 prolyl oligopeptidase fam prt ( )
NMB0532 protease DO, AFS (htrA)
NMB1664 protease, put ( )
NMB1587 protease, put ( )
NMB2127 protease, put ( )
NMB1203 prt-PII uridylylTase (glnD)
NMB1998 serine-type peptidase ( )
NMB1969 serotype-1-specific antigen, put ( )
Regulatory functions
NMB0668 ampD prt (ampD)
NMB2075 BirA prt/Bvg accessory factor ( )
NMB2075 BirA prt/Bvg accessory factor ( )
NMB0381 cys regulon transcriptional activator (cysB)
NMB0595 DNA-binding response regulator
NMB0205 ferric uptake reg prt (fur)
NMB1735 GTP pyrophosphokinase (relA)
NMB1659 guanosine-3`,5`-bis(diP) 3`-pyrophosphohydrolase (spoT)
NMB0748 host factor-I (hfq)
NMB0737 HPr kinase/PPase, put ( )
NMB0729 integration host factor, alpha sub (himA)
NMB1302 integration host factor, beta sub (himD)
NMB1650 leucine-responsive reg prt (lrp)
NMB1267 low molecular weight prt tyrosine-PPase ( )
NMB1249 nitrate/nitrite sensory prt NarX, put ( )
NMB0115 nitrogen assimilation reg prt NtrX (ntrX)
NMB0114 nitrogen reg prt NtrY, put ( )
NMB1995 nitrogen reg prt P-II (glnB)
NMB0044 peptide methionine sulfoxide RDase (pilB)
NMB0556 repressor prt, put
NMB1793 response reg, put, AFS ( )
NMB0646 ribonuclease inhibitor barstar ( )
NMB0594 sensor histidine kinase
NMB1792 sensor histidine kinase ( )
NMB1606 sensor histidine kinase ( )
NMB1607 sigma-54 dep response regulator ( )
NMB2066 tldD prt (tldD)
NMB1717 trancscriptional reg MtrR (mtrR)
NMB1007 transcriptional regulator
NMB1204 transcriptional regulator ( )
NMB0910 transcriptional regulator ( )
NMB1591 transcriptional reg MtrA (mtrA)
NMB1967 transcriptional reg, AraC fam ( )
NMB1878 transcriptional reg, AraC fam ( )
NMB0398 transcriptional reg, ArsR fam ( )
NMB0573 transcriptional reg, AsnC fam
NMB0380 transcriptional reg, Crp/Fnr fam ( )
NMB1561 transcriptional reg, DeoR fam ( )
NMB1711 transcriptional reg, GntR fam ( )
NMB1563 transcriptional reg, GntR fam ( )
NMB2012 transcriptional reg, HTH_3 fam ( )
NMB1250 transcriptional reg, LuxR fam ( )
NMB1856 transcriptional reg, LysR fam ( )
NMB2055 transcriptional reg, LysR fam ( )
NMB0173 transcriptional reg, LysR fam ( )
NMB1585 transcriptional reg, MarR fam ( )
NMB1843 transcriptional reg, MarR fam ( )
NMB1303 transcriptional reg, MerR fam
NMB1049 transcriptional reg, put ( )
NMB0290 transcriptional reg, put ( )
NMB0810 transcriptional reg, TetR fam ( )
NMB1078 transcriptional reg, UmuD/LexA fam, AFS ( )
NMB1266 Zn uptake reg prt, put (zur)
Cell envelope
Lipoproteins
NMB0713 apolipoprt N-acylTase, put ( )
NMB0703 competence lipoprt ComL (comL)
NMB1898 lipoprt (mlp)
NMB1483 lipoprt NlpD, put ( )
NMB1623 major anaerobically induced outer membrane prt (pan1)
NMB1716 membrane fusion prt (mtrC)
NMB1946 outer membrane lipoprt ( )
NMB0873 outer membrane lipoprt LolB, put ( )
NMB1072 prolipoprt diacylglyceryl Tase (lgt)
NMB0707 rare lipoprt B, put ( )
Surface structures
NMB0992 adhesin (hsf)
NMB0586 adhesin, put
NMB1994 adhesin/invasin, put ( )
NMB1487 fimbrial assembly prt (fimB)
NMB0025 large pilS cassette ( )
NMB1847 pilC1 prt, AFS (pilC1)
NMB0049 pilC2 prt, AFS (pilC2)
NMB1820 pilin glycosylation prt PglB (pglB)
NMB1821 pilin glycosylation prt PglC (pglC)
NMB1822 pilin glycosylation prt PglD (pglD)
NMB0018 pilin PilE (pilE)
NMB1808 pilM prt (pilM)
NMB1809 pilN prt, AFS (pilN)
NMB1810 pilO prt (PilO)
NMB1811 pilP prt (pilP)
NMB1812 pilQ prt, AFS (pilQ)
NMB0019 pilS cassette ( )
NMB0022 pilS cassette ( )
NMB0026 pilS cassette ( )
NMB0020 pilS cassette ( )
NMB0021 pilS cassette ( )
NMB0023 pilS cassette ( )
NMB0024 pilS cassette ( )
NMB0333 pilus assembly prt PilG (pilG)
NMB0547 type IV pilin prt
NMB0329 type IV pilus assembly prt (pilF)
NMB0887 type IV pilus assembly prt PilV, putatve ( )
NMB0770 type IV pilus assembly prt PilZ, put ( )
NMB0332 type IV prepilin peptidase (pilD)
Biosynthesis of murein sacculus and peptidoglycan
NMB1651 alanine racemase (alr)
NMB0424 D-alanine--D-alanine ligase (ddlB)
NMB0458 glutamate racemase (murI)
NMB0357 monofunctional biosynthetic peptidoglycan transglycosylase (mtgA)
NMB0987 N-acetylmuramoyl-L-alanine amidase, put
NMB1085 N-acetylmuramoyl-L-alanine amidase, put
NMB0877 penicillin-Bprt ( )
NMB1807 penicillin-Bprt 1 (ponA)
NMB0413 penicillin-Bprt 2 (penA)
NMB1797 penicillin-Bprt 3 ( )
NMB0749 penicillin-Bprt 4 ( )
NMB0418 phospho-N-acetylmuramoyl-pentapeptide-Tase (mraY)
NMB0011 UDP-N-acetylglucosamine 1-carboxyvinylTase (murA)
NMB0038 UDP-N-acetylglucosamine pyrophosphorylase (glmU)
NMB0422 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine Tase (murG)
NMB0423 UDP-N-acetylmuramate--alanine ligase (murC)
NMB1145 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (mpl-1)
NMB1183 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (mpl-2)
NMB0420 UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
NMB0414 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE)
NMB0416 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase (murF)
NMB0811 UDP-N-acetylpyruvoylglucosamine RDase (murB)
Biosynthesis and degradation of surface polysaccarides and lipopolysaccharides
NMB1283 2-dehydro-3-deoxyphosphooctonate aldolase (kdsA)
NMB0675 3-deoxy-D-manno-octulosonate cytidylylTase (kdsB)
NMB0014 3-deoxy-D-manno-octulosonic-acid Tase (kdtA)
NMB0178 acyl-(acyl-carrier-prt)--UDP-N-acetylglucosamine O-acylTase (lpxA)
NMB0825 ADP-heptose Sase, put ( )
NMB1527 ADP-heptose--LPS heptosylTase II (rfaF)
NMB0828 ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD)
NMB1705 alpha-1,2-N-acetylglucosamine Tase (rfaK)
NMB1704 beta-1,4-glucosylTase (lgtF)
NMB0082 capsule polysaccharide modification prt LipA (lipA)
NMB0083 capsule polysaccharide modification prt LipB (lipB)
NMB1359 CDP-6-deoxy-delta-3,4-glucoseen RDase, put ( )
NMB0081 dTDP-4-keto-6-deoxy-D-glucose-3,6-epimerase ( )
NMB0061 dTDP-6-deoxy-L-lyxo-4-hexulose RDase (rfbC)
NMB0079 dTDP-D-glucose 4,6-dehydratase (rfbB-2)
NMB0063 dTDP-D-glucose 4,6-dehydratase (rfbB-1)
NMB0756 dTDP-L-rhamnose Sase, put ( )
NMB0080 glucose-1-P thymidylylTase (rfbA-2)
NMB0062 glucose-1-P thymidylylTase (rfbA-1)
NMB1255 glycosyl Tase, degenerate ( )
NMB2156 heptosylTase I (rfaC)
NMB1929 lacto-N-neotetraose biosynthesis glycosyl Tase LgtA (lgtA)
NMB1928 lacto-N-neotetraose biosynthesis glycosyl Tase LgtB (lgtB)
NMB1926 lacto-N-neotetraose biosynthesis glycosyl Tase LgtE (lgtE)
NMB0199 lipid-A-disaccharide Sase (lpxB)
NMB1836 LPS biosynthesis prt WbpC, put ( )
NMB1818 LPS biosynthesis prt, put
NMB2019 LPS core biosynthesis prt KdtB (kdtB)
NMB2032 LPS glycosyl Tase, AFS (lgtG)
NMB0033 membrane-bound lytic murein transglycosylase A, put ( )
NMB1279 membrane-bound lytic murein transglycosylase B, put ( )
NMB1297 membrane-bound lytic murein transglycosylase D ( )
NMB0456 N-acetylmuramoyl-L-alanine amidase (amiC)
NMB0285 O-antigen acetylase, AFS ( )
NMB0790 phosphoglucomutase (pgm)
NMB2090 phosphoheptose isomerase (gmhA)
NMB0069 polysialic acid capsule biosynthesis prt SiaB (siaB)
NMB0068 polysialic acid capsule biosynthesis prt SiaC (siaC)
NMB0067 polysialic acid capsule biosynthesis prt SiaD, truncation ( )
NMB0070 polysialic acid capsule biosynthesis prt SynX (synX)
NMB1949 soluble lytic murein transglycosylase, put ( )
NMB0017 UDP-3-O-3-hydroxymyristoyl N-acetylglucosamine deacetylase (envA)
NMB0064 UDP-glucose 4-epimerase (galE)
NMB0078 UDP-glucose 4-epimerase, truncation ( )
NMB0038 UDP-N-acetylglucosamine pyrophosphorylase (glmU)
Other
NMB1907 60 kd inner-membrane prt (yidC)
NMB1273 alginate O-acetylation prt AlgI, put ( )
NMB0345 cell-binding factor, put ( )
NMB1053 class 5 outer membrane prt (opc)
NMB0304 class 5 outer membrane prt, degenerate ( )
NMB1533 H.8 outer membrane prt ( )
NMB0587 membrane prt
NMB0382 outer membrane prt class 4 (rmpM)
NMB0663 outer membrane prt NsgA (nsgA)
NMB0182 outer membrane prt Omp85 (omp85)
NMB0181 outer membrane prt OmpH, put ( )
NMB0088 outer membrane prt P1, put ( )
NMB0946 peroxiredoxin 2 fam prt/glutaredoxin ( )
Cellular processes
Cell division
NMB0007 cell division ATP-Bprt FtsE (ftsE)
NMB0426 cell division prt FtsA (ftsA)
NMB0798 cell division prt FtsH (ftsH)
NMB0799 cell division prt FtsJ (ftsJ)
NMB1314 cell division prt FtsK (ftsK-2)
NMB1067 cell division prt FtsK (ftsK-1)
NMB0425 cell division prt FtsQ (ftsQ)
NMB0421 cell division prt FtsW (ftsW)
NMB0008 cell division prt FtsX, put ( )
NMB0427 cell division prt FtsZ (ftsZ)
NMB0172 cell division topological specificity factor (minE)
NMB1791 cytoplasmic axial filament prt, AFS (cafA)
NMB0342 intracellular septation prt A (ispA)
NMB1140 mesJ prt, AFS (mesJ-1)
NMB1178 mesJ prt, AFS (mesJ-2)
NMB0191 ParA fam prt
NMB0170 septum site-determining prt MinC (minC)
NMB0171 septum site-determining prt MinD (minD)
Chemotaxis and motility
NMB1309 fimbrial biogenesis and twitching motility prt, put
NMB0051 twitching motility prt ( )
NMB0768 twitching motility prt PilT (pilT-2)
NMB0052 twitching motility prt PilT (pilT-1)
Detoxification
NMB0525 aluminum resistance prt, put
NMB0005 arsenate RDase (arsC)
NMB1955 cadmium resistance prt ( )
NMB0216 catalase (kat)
NMB1398 Cu-Zn-superoxide dismutase (sodC)
NMB1621 glutathione peroxidase (gpxA)
NMB1714 multidrug efflux pump channel prt (mtrE)
NMB0280 organic solvent tolerance prt, put ( )
NMB0884 superoxide dismutase (sodB)
NMB1987 thiophene and furan oxidation prt ThdF (thdF)
Transformation
NMB0703 competence lipoprt ComL (comL)
NMB0269 competence prt ( )
NMB0702 competence prt ComA (comA)
NMB0405 competence prt ComM (comM)
NMB0116 DNA processing chain A (dprA)
NMB1847 pilC1 prt, AFS (pilC1)
NMB0049 pilC2 prt, AFS (pilC2)
NMB0018 pilin PilE (pilE)
NMB1808 pilM prt (pilM)
NMB1809 pilN prt, AFS (pilN)
NMB1810 pilO prt (PilO)
NMB1811 pilP prt (pilP)
NMB1812 pilQ prt, AFS (pilQ)
NMB0692 tpc prt (tpc)
NMB0329 type IV pilus assembly prt (pilF)
NMB0332 type IV prepilin peptidase (pilD)
Toxin production and resistance
NMB0668 ampD prt (ampD)
NMB0408 bacitracin resistance prt (bacA)
NMB0582 bacteriocin resistance prt, put
NMB0855 bacteriocin resistance prt, put ( )
NMB0103 bacteriocin resistance prt, put ( )
NMB0697 dimethyladenosine Tase (ksgA)
NMB0497 hemagglutinin/hemolysin-rel prt
NMB1768 hemagglutinin/hemolysin-rel prt ( )
NMB0493 hemagglutinin/hemolysin-rel prt ( )
NMB1779 hemagglutinin/hemolysin-rel prt ( )
NMB1214 hemagglutinin/hemolysin-rel prt ( )
NMB1762 hemolysin activation prt HecB, put ( )
NMB1780 hemolysin activation prt HecB, put ( )
NMB1646 hemolysin, put ( )
NMB2091 hemolysin, put ( )
NMB1831 lytB prt (lytB)
NMB1857 modulator of drug activity B (mdaB)
NMB0977 modulator of drug activity B, put ( )
NMB0839 pmbA prt (pmbA)
NMB0066 rRNA adenine N-6-methylTase (ermC)
NMB1603 tellurite resistance prt, put ( )
NMB1617 tellurite resistance prt, put ( )
NMB1210 toxin-activating prt, put ( )
NMB1763 toxin-activating prt, put ( )
Pathogenesis
NMB0992 adhesin (hsf)
NMB2095 adhesin complex prt, put ( )
NMB0586 adhesin, put
NMB1994 adhesin/invasin, put ( )
NMB1985 adhesion and penetration prt (hap)
NMB1309 fimbrial biogenesis and twitching motility prt, put
NMB0584 FrpC operon prt
NMB1412 FrpC operon prt ( )
NMB1414 FrpC operon prt ( )
NMB0364 FrpC operon prt ( )
NMB0497 hemagglutinin/hemolysin-rel prt
NMB1768 hemagglutinin/hemolysin-rel prt ( )
NMB0493 hemagglutinin/hemolysin-rel prt ( )
NMB1779 hemagglutinin/hemolysin-rel prt ( )
NMB1214 hemagglutinin/hemolysin-rel prt ( )
NMB0585 Fe-regulated prt FrpA, put
NMB1415 Fe-regulated prt FrpC (frpC)
NMB0365 Fe-regulated prt FrpC, truncation
NMB0025 large pilS cassette ( )
NMB1567 macrophage infectivity potentiator ( )
NMB0442 opacity prt, AFS ( )
NMB0926 opacity prt, AFS ( )
NMB1465 opacity prt, AFS ( )
NMB1636 opacity prt, AFS ( )
NMB1847 pilC1 prt, AFS (pilC1)
NMB0049 pilC2 prt, AFS (pilC2)
NMB1552 pilin gene inverting prt PivNM-1A (pivNM-1A)
NMB1625 pilin gene inverting prt PivNM-1B (pivNM-1B)
NMB1750 pilin gene inverting prt PivNM-2 (pivNM-2)
NMB1820 pilin glycosylation prt PglB (pglB)
NMB1821 pilin glycosylation prt PglC (pglC)
NMB1822 pilin glycosylation prt PglD (pglD)
NMB0018 pilin PilE (pilE)
NMB1808 pilM prt (pilM)
NMB1809 pilN prt, AFS (pilN)
NMB1810 pilO prt (PilO)
NMB1811 pilP prt (pilP)
NMB1812 pilQ prt, AFS (pilQ)
NMB0019 pilS cassette ( )
NMB0022 pilS cassette ( )
NMB0026 pilS cassette ( )
NMB0020 pilS cassette ( )
NMB0021 pilS cassette ( )
NMB0023 pilS cassette ( )
NMB0024 pilS cassette ( )
NMB0333 pilus assembly prt PilG (pilG)
NMB0851 recombination associated prt RdgC (rdgC)
NMB0553 transposase, put, APM ( )
NMB0547 type IV pilin prt
NMB0329 type IV pilus assembly prt (pilF)
NMB0887 type IV pilus assembly prt PilV, put ( )
NMB0770 type IV pilus assembly prt PilZ, put ( )
NMB0332 type IV prepilin peptidase (pilD)
NMB0277 virulence factor MviN (mviN)
NMB0312 virulence-associated prt VapA, AFS (vapA)
Adaptations to atypical conditions
NMB0838 cold-shock domain fam prt ( )
NMB0784 phage shock prt E precursor, put ( )
NMB1484 stationary-phase survival prt SurE (surE)
NMB1953 stringent starvation prt A (sspA)
Other categories
Plasmid-related functions
NMB0914 pemI prt (pemI)
NMB0913 pemK prt (pemK)
NMB0495 replication prt ( )
Phage-related functions and prophages
NMB1083 bacteriophage DNA transposition prt B, put ( )
NMB1081 bacteriophage transposase ( )
NMB1111 baseplate assembly prt V, put ( )
NMB1097 cryptic Mu-phage G prt, put, AFS ( )
NMB0917 death-on-curing prt ( )
NMB0961 funZ prt (funZ)
NMB0748 host factor-I (hfq)
NMB1098 I prt, put ( )
NMB1001 integrase prt, degenerate ( )
NMB0896 integrase, AFS ( )
NMB1080 ner prt, AFS (ner)
NMB1104 phage sheath prt ( )
NMB1109 phage virion prt, put
NMB0556 repressor prt, put
NMB1115 tail fibre prt, put ( )
NMB1110 tail prt, 43 kDa ( )
Transposon-related functions
NMB1083 bacteriophage DNA transposition prt B, put ( )
NMB1081 bacteriophage transposase ( )
NMB0238 IS1016 fam transposase, degenerate
NMB0616 IS1016 fam transposase, degenerate
NMB1385 IS1016 fam transposase, degenerate ( )
NMB1769 IS1016 fam transposase, put truncation
NMB1798 IS1016 fam transposase, put, AFS ( )
NMB0090 IS1016 fam transposase, put, AFS ( )
NMB0101 IS1016 fam transposase, put, AFS ( )
NMB1413 IS1016 fam transposase, put, AFS ( )
NMB2126 IS1016 fam transposase, put, degenerate
NMB1401 IS1016C2 transposase ( )
NMB1411 IS1016C2 transposase ( )
NMB0583 IS1016C2 transposase
NMB1901 IS1016C2 transposase, degenerate ( )
NMB1974 IS1016C2 transposase, degenerate ( )
NMB0302 IS1016C2 transposase, degenerate ( )
NMB1399 IS1106 transposase ( )
NMB1539 IS1106 transposase ( )
NMB1601 IS1106 transposase ( )
NMB0991 IS1106 transposase ( )
NMB1984 IS1106 transposase, AFS ( )
NMB1922 IS1106 transposase, degenerate ( )
NMB1463 IS1106 transposase, degenerate ( )
NMB1054 IS1106 transposase, degenerate ( )
NMB0919 IS1106 transposase, put ( )
NMB2043 IS1106 transposase, put, degenerate ( )
NMB1000 IS1106 transposase, put, degenerate ( )
NMB1015 IS150 transposase, put, degenerate ( )
NMB1751 transposase, degenerate ( )
NMB0443 transposase, IS30 fam ( )
NMB0805 transposase, IS30 fam ( )
NMB0834 transposase, IS30 fam ( )
NMB0911 transposase, IS30 fam ( )
NMB2148 transposase, IS30 fam ( )
NMB1251 transposase, IS30 fam ( )
NMB1259 transposase, IS30 fam ( )
NMB1713 transposase, IS30 fam ( )
NMB1099 transposase, IS30 fam ( )
NMB0225 transposase, IS30 fam ( )
NMB0635 transposase, IS30 fam ( )
NMB1022 transposase, IS30 fam ( )
NMB1770 transposase, IS30 fam ( )
NMB1050 transposase, IS30 fam ( )
NMB1386 transposase, put ( )
NMB1736 transposase, put, AFS
NMB0522 transposase, truncated
NMB1553 transposase, truncation ( )
NMB0141 transposase, truncation ( )
Unknown
General
NMB2008 ABC transp, ATP-Bprt-rel prt
NMB0548 AcrA/AcrE fam prt
NMB0925 acyl CoA thioester hydrolase fam prt ( )
NMB1482 acyl CoA thioester hydrolase fam prt ( )
NMB0994 acyl-CoA DHase fam prt ( )
NMB0360 AmpG-rel prt ( )
NMB2076 aut prt (aut)
NMB0892 AzlC-rel prt ( )
NMB0750 bacterioferritin comigratory prt (bcp)
NMB0009 BolA/YrbA fam prt ( )
NMB0344 BolA/YrbA fam prt ( )
NMB1434 cardiolipin Sase fam prt ( )
NMB0296 CcsA-rel prt ( )
NMB0412 cell division prt FtsL-rel prt ( )
NMB0255 cell filamentation prt Fic-rel prt ( )
NMB2006 Cl- channel prt-rel prt ( )
NMB0982 Cl- channel prt-rel prt ( )
NMB1692 chorismate mutase-rel prt ( )
NMB2128 CinA-rel prt ( )
NMB1263 CobW-rel prt ( )
NMB1657 comE operon prt 1-rel prt ( )
NMB2017 ComEA-rel prt ( )
NMB0299 comEA-rel prt ( )
NMB1065 crcB prt (crcB)
NMB1335 creA prt (creA)
NMB1754 cryptic plasmid prt A-rel prt
NMB0680 cryptic prt (cnp1)
NMB1978 cyaY prt (cyaY)
NMB0933 cytidine and deoxycytidylate deaminase fam prt ( )
NMB0901 D-lactate DHase-rel prt
NMB1052 dedA prt (dedA)
NMB1689 dedA prt, put ( )
NMB0934 DNA transformation prt tfoX-rel prt
NMB1448 DNA-damage-inducible prt P (dinP)
NMB1076 DnaA-rel prt ( )
NMB0985 E16-rel prt
NMB0004 EpiH/GdmH-rel prt ( )
NMB0852 essential GTPase ( )
NMB1347 extragenic suppressor prt SuhB (suhB)
NMB1516 fixS prt (fixS)
NMB1407 FrpA-rel prt, degenerate ( )
NMB1405 FrpA/C-rel prt ( )
NMB1409 FrpA/C-rel prt ( )
NMB0624 galactosylTase-rel prt, AFS
NMB1310 gcpE prt (gcpE)
NMB0193 glucose inhibited division prt A (gidA)
NMB0190 glucose inhibited division prt B (gidB)
NMB0349 glutamyl-tRNA Sase-rel prt ( )
NMB2049 glyoxalase II fam prt ( )
NMB2086 GTP-Bprt ( )
NMB0687 GTP-Bprt Era (era)
NMB0766 GTP-Bprt LepA (lepA)
NMB1199 GTP-Bprt TypA (typA)
NMB1041 GTP-Bprt, AFS ( )
NMB1838 GTP-Bprt, put ( )
NMB1891 helix-turn-helix fam prt ( )
NMB1501 HesA/MoeB/ThiF fam prt ( )
NMB1381 HesB/YadR/YfhF fam prt ( )
NMB0602 hitA prt (hitA)
NMB1801 HtrB/MsbB fam prt ( )
NMB1418 HtrB/MsbB fam prt ( )
NMB1924 inositol monoPPase fam prt ( )
NMB1669 Fe-starvation prt PigA ( )
NMB1712 L-lactate permease-rel prt ( )
NMB1927 lacto-N-neotetraose biosynthesis glycosyl Tase-rel prt
NMB0204 lipoprt, put (smpA)
NMB0846 LPS biosynthesis prt-rel prt ( )
NMB0995 macrophage infectivity potentiator-rel prt ( )
NMB0598 Maf/YceF/YhdE fam prt
NMB1909 Maf/YceF/YhdE fam prt ( )
NMB0652 mafA prt (mafA-2)
NMB1841 mannose-1-P guanylTase-rel prt ( )
NMB1846 Mrp/NBP35 fam prt ( )
NMB1421 nifR3 prt ( )
NMB0999 NifR3/SMM1 fam prt ( )
NMB0577 NosR-rel prt
NMB1944 ParB fam prt ( )
NMB2038 PemK-rel prt ( )
NMB1238 peptidyl-prolyl cis-trans isomerase-rel prt ( )
NMB0946 peroxiredoxin 2 fam prt/glutaredoxin ( )
NMB0037 phnA prt (phnA)
NMB0105 PhnO-rel prt ( )
NMB0845 PhoH-rel prt ( )
NMB0963 phosphatidylserine decarboxylase precursor-rel prt ( )
NMB1521 phytoene Sase-rel prt ( )
NMB1670 PqiA fam prt ( )
NMB1671 pqiB prt (pqiB)
NMB1389 RpiR/YebK/YfhH fam prt ( )
NMB2063 slyX prt, put ( )
NMB1526 small major prt B ( )
NMB0117 smg prt, put ( )
NMB1220 stomatin/Mec-2 fam prt ( )
NMB1952 stringent starvation prt B (sspB)
NMB2041 thiamin pyrophosphokinase-rel prt ( )
NMB0006 thioredoxin-rel prt ( )
NMB2132 transferrin-Bprt-rel prt
NMB0341 tspA prt ( )
NMB1747 tspB prt, put ( )
NMB1548 tspB prt, put ( )
NMB1628 tspB prt, put ( )
NMB0480 TspB-rel prt ( )
NMB0976 TspB-rel prt ( )
NMB0833 type I restriction enzyme-rel prt ( )
NMB0827 type II restriction enzyme-rel prt, AFS
NMB1961 VacJ-rel prt ( )
NMB1753 VapD-rel prt ( )
NMB1525 VirG-rel prt, AFS ( )
NMB0867 YabO/YceC/SfhB fam prt ( )
NMB1512 YgbB/YacN fam prt ( )
NMB2010 YhbX/YhjW/YijP/YjdB fam prt ( )
NMB1638 YhbX/YhjW/YijP/YjdB fam prt ( )
Disrupted reading frame
NMB0523 ABC transp, ATP-Bprt, truncation
NMB1077 ABC transp, ATP-Bprt, truncation ( )
NMB2009 ATP-dep RNA helicase HrpA, degenerate ( )
NMB2007 ATP-dep RNA helicase HrpA, truncation ( )
NMB2011 ATP-dep RNA helicase HrpA, truncation ( )
NMB0661 bis(5`-nucleosyl)-tetraPPase, symmetrical/Trk system K+ uptake prt TrkG, fusion ( )
NMB0304 class 5 outer membrane prt, degenerate ( )
NMB1752 conserved hypothetical prt, degenerate
NMB1722 cytochrome C555, truncation ( )
NMB1895 DNA adenine methylase, truncation ( )
NMB0494 DNA helicase, truncation ( )
NMB1027 dnaJ prt, truncation ( )
NMB1407 FrpA-rel prt, degenerate ( )
NMB1255 glycosyl Tase, degenerate ( )
NMB1001 integrase prt, degenerate ( )
NMB0365 Fe-regulated prt FrpC, truncation
NMB0238 IS1016 fam transposase, degenerate
NMB0616 IS1016 fam transposase, degenerate
NMB1385 IS1016 fam transposase, degenerate ( )
NMB1769 IS1016 fam transposase, put truncation
NMB2126 IS1016 fam transposase, put, degenerate
NMB1901 IS1016C2 transposase, degenerate ( )
NMB1974 IS1016C2 transposase, degenerate ( )
NMB0302 IS1016C2 transposase, degenerate ( )
NMB1922 IS1106 transposase, degenerate ( )
NMB1463 IS1106 transposase, degenerate ( )
NMB1054 IS1106 transposase, degenerate ( )
NMB2043 IS1106 transposase, put, degenerate ( )
NMB1000 IS1106 transposase, put, degenerate ( )
NMB1015 IS150 transposase, put, degenerate ( )
NMB0067 polysialic acid capsule biosynthesis prt SiaD, truncation ( )
NMB0097 secretion prt, put, degenerate ( )
NMB1257 site-specific DNA methylase, degenerate ( )
NMB0210 site-specific DNA methylase, truncation ( )
NMB0077 site-specific DNA methylase, truncation ( )
NMB1299 Na+- and Cl--dep transp, degenerate
NMB1751 transposase, degenerate ( )
NMB0522 transposase, truncated
NMB1553 transposase, truncation ( )
NMB0141 transposase, truncation ( )
NMB0831 type I restriction enzyme S prt, degenerate ( )
NMB0078 UDP-glucose 4-epimerase, truncation ( )

Table 1. N. meningitidis strain MC58 gene list.
Gene identification numbers that correspond to those in Figure 1 are listed here with the prefix NMB followed by the common name assigned to each protein, and the gene name in parentheses. Each gene is listed in its functional role category, note that a given gene may appear in more than one category. In cases where the substrate specificity of a protein could not be unambiguously determined, a more general common name was used and no gene name was assigned. In some cases, a gene without a confident substrate specificity could be assigned to a particular family from PROSITE (http://expasy.org/prosite), SWISS-PROT (http://expasy.org/sprot) or, Pfam (http://www.sanger.ac.uk/Pfam/search.shtml). The term "-related" is used in two ways in the common names: i) when the NMB protein is a partial but significant match to a database protein, the NMB protein is assigned to the Unknown role category or ii) when the NMB protein is a very good match to a database protein whose function is not found in N. meningitidis; the NMB protein may be assigned to a role category appropriate to the known function of the database match. In some cases the sequence of an ORF will be interrupted by a single frameshift or point mutation which has been checked and confirmed to be present in the sequence. In these cases we put "authentic frameshift" or "authentic point mutation" after the common name. In cases where the sequence is so disrupted as to appear completely non-functional we put the gene into the role category "Disrupted reading frames" as well as the role category corresponding to the match. Following the common name is a term describing the type of disruption the orf has: "truncation" indicates that the orf is much shorter than the gene it matches; "degenerate" indicates the orf has multiple frameshifts, point mutations, or both.
Abbreviations: AA, amino acid; BRAA, branched chain AA; Bprt, binding protein; CoA, coenzyme A; DHase, dehydrogenase; LPS, lipopolysaccharide; OP, oligopeptide; P, phosphate; PPR, phosphoribosyl; PPase, phosphatase; RDase, reductase; Sase, synthase; Tase, transferase; dep, dependent; elong, elongation; fam, family; flgr, flagellar; init, initiation; prt, protein; put, putative; reg, regulator; rel, related; ssDNA, single stranded DNA; sub, subunit ; term, termination; transp, transporter.


Figure 1. Linear representation of the N. meningitidis strain MC58 genome
. The location of predicted coding regions color-coded by biological role is displayed, as well as rRNA and tRNAs genes. Arrows represent the direction of transcription for each predicted coding region. Numbers next to the tRNA symbols represent the number of tRNAs at a locus. Numbers next to GES regions represent the number of membrane-spanning domains predicted by the Goldman, Engelman and Steitz scale as calculated by TopPred [M. G. Claros and G. von Heijne, Comput. Appl. Biosci. 10, 685 (1994)] (displayed only for ORF products with five or more predicted membrane spanning regions). Presumed transporter specificity is indicated with abbreviations: aa, amino acid; aaX, oligopeptides; s/p, spermidine/putrescine. Question marks (?) indicate where substrate specificity is uncertain or unknown.


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Figure 2. Integrated view of metabolic functions and solute transport predicted from genome annotation of N. meningitidis strain MC58.
Biosynthetic and catabolic reactions are schematically presented in the center of concentric blue ovals symbolizing cytoplasmic and periplasmic membranes. Enzymes contributing to a complete TCA cycle (gray circle); Entner-Doudoroff and non-oxidative Pentose Phosphate pathways (black boxes); glycolysis/gluconeogenesis, fatty acid biosynthesis, and nucleotide biosynthesis (red arrows) are summarized with primary substrates Acetyl-CoA, gluconate, glucose, PEP, acetoacetyl-ACP, and xanthine, respectively. Synthesis of several amino acids stem from these central pathways. Transport proteins in each membrane are color coded according to substrate specificity as follows: cation transporters in green; systems for carbohydrates, alcohols, or acids are yellow; outer membrane transporters in pink; organic amine uptake systems in blue; anion transporters in red; nucleoside, purine and pyrimidine systems in purple; and drug efflux pumps in orange. Symbols that represent transporter superfamilies include the ion and solute-coupled permeases as ovals and ATP-binding cassette (ABC) transporters as composites of diamonds, circles, and ovals . Also notable in N. meningitidis are several putative TonB-dependent receptors with similarity to import systems for ferric iron siderophores. Transport via these receptors is mediated by tonB/exbB/exbD gene products. Locus number or gene name, solute transported, and flux direction are associated with each symbol. Labels in black have significant sequence similarity to transporters characterized in N. meningitidis or other bacteria, while those in blue are putative annotations. Solute-binding proteins encoded by merP (mercury ions) and brfAB-bacterioferritin (ferric iron ions) genes are also shown. Abbreviations are as follows: PRPP, phosphoribosyl phyrophosphate; PEP, phosphoenoylpyruvate.


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