Special CollectionThe Ebola Epidemic

Samuel Hanryon/MSF

Given the current outbreak, unprecedented in terms of number of people killed and rapid geographic spread, Science and Science Translational Medicine have made this collection of research and news articles on the viral disease freely available to researchers and the general public.

#Ebola Must Reads

Science reporters have highlighted these top stories from their coverage as must reads:

Research

26 March 2015 | Research Report

Mutation rate and genotype variation of Ebola virus from Mali case sequences

Science | T. Hoenen et al.

Ebola virus has not mutated faster during the current outbreak in West Africa than historically observed..

26 March 2015 | Research Report

An Ebola whole-virus vaccine is protective in nonhuman primates

Science | A. Marzi et al.

Preliminary results in primates offer promising results for an inactivated, peroxide-treated whole virus vaccine candidate for Ebola.

20 November 2014 | Science Careers Profiles

The road to Ebola

A structural biologist, a molecular virologist, and a microbiologist share their stories on why they considered working with Ebola.

Rachel Bernstein

30 October 2014 | Research Report

Strategies for containing Ebola in West Africa

Science | A. Pandey et al.

A combination of hygienic practices could feasibly check Ebola within six months.

30 October 2014 | Research Report

Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance

Science | A. L. Rasmussen et al.

Intercrossed mice infected with Ebola virus show the spectrum of pathology from prolonged coagulation to total resistance.

28 August 2014 | Report

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

Science | Gire et al.

Sequenced Ebola virus informs upon the current disease epidemic.

20 August 2014 | Research Article

Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA

Science Translational Medicine | Emily Thi et al.

Lipid nanoparticle delivery of siRNAs against the virus nucleoprotein treats Marburg virus infection in nonhuman primates after symptom onset.

19 August 2014 | Editors' Choice

How Ebola Shuts Down Antiviral Signaling

Science Signaling | A. M. VanHook

16 October 2013 | Research Article

Monoclonal antibodies and interferon therapy rescue Ebola-infected nonhuman primates when administered after symptoms start

Science Translational Medicine | Xiangguo Qiu et al.

Monoclonal antibodies and adenovirus-vectored IFNα extends the treatment window for Zaire ebolavirus in macaques.

21 August 2013 | Research Article

Therapy for Ebola virus infection in rhesus macaques with a monoclonal antibody cocktail

Science Translational Medicine | James Pettitt et al.

Ebola virus-infected macaques were successfully treated with a cocktail of monoclonals manufactured in plants.

19 June 2013 | Research Article

Estrogen receptor modulators inhibit Ebola virus infection

Science Translational Medicine | Lisa M. Johansen et al.

Clomiphene and toremifene inhibit Ebola virus infection.

31 October 2012 | Research Article

Immune parameters correlate with protection against Ebola virus infection

Science Translational Medicine | Gary Wong et al.

Antibody induction may serve as a surrogate for survival in protecting against Ebola infection.

13 June 2012 | Research Article

Successful treatment of Ebola virus–infected macaques with monoclonal antibodies

Science Translational Medicine | Xiangguo Qiu et al.

Macaques survived infection with Ebola virus when treated 24 hours after infection with mix of 3 neutralizing monoclonal antibodies.

C. Bickel/Science

29 February 2012 | Research Article

Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase

Science Translational Medicine | Garcia et al.

Productive replication of Ebola virus is modulated by the c-Abl1 tyrosine kinase.

2012 | Perspective

Emerging Disease or Diagnosis?

Science | Gire et al.

Some viral infections, including ebolavirus, may not represent emerging diseases, but improved detection and diagnosis of common diseases.

2009 | Report

Discovery of Swine as a Host for the Reston ebolavir

Science | Barrette et al.

Respiratory infections in pigs in the Philippines are associated with a cocktail of viruses, including a monkey filovirus.

2006 | Report

Ebola Outbreak Killed 5000 Gorillas

Science | Bermejo et al.

Successive waves of Ebola virus infection and hunting pressure are threatening the great apes of West Africa with extinction.

2005 | Brevia

Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection

Science | Chandran et al.

For the Ebola virus to infect successfully, a host enzyme must digest a surface protein on the virus, suggesting a new target for treatment of this fatal infection.

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3D model of the Ebola virus
Ivan Konstantinov et al.Visual Science

Honorable mention in the 2011 International Science and Engineering Visualization Challenge

European Commission DG ECHO/flickr

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