Welcome to Science’s latest crossword puzzle, marking our 2020 Breakthrough of the Year. Many of the clues or answers are general science facts, but others come from this year’s breakthrough or the runner-ups, or from honorees in past years. You can use the puzzle’s “Show a hint” option on those, which are noted with *. And after the puzzle is fully solved or revealed, some clues will offer links to related stories. Enjoy!