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Vote for your scientific breakthrough of the year!

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The season of holidays, shopping lists, and end-of-the-year retrospectives is upon us.  Here at Science, in keeping with tradition, our news writers and editors are getting ready to unveil the 21st “Breakthrough of the Year”: their choice of the most momentous scientific discovery, development, or trend of 2016, to be announced when the last issue of the year goes online on 22 December. They’ll also choose 9 runners-up and will highlight “Areas to Watch”: important developments likely to pay off next year.

But there’s no need to wait—you can get in on the action now! Pick your favorite breakthrough from the list below by Sunday, December 4. Then check back next Monday–we'll be doing a second voting round with your 5 finalists to pick the official winner. We'll announce the People's Choice selection, along with our editors' pick, on December 22.

Which breakthrough will you choose? Cast your vote today!