Free Sample Articles from Science Signaling

This special collection of freely available Research Articles from Science Signaling is intended for those researchers interested in the topics discussed at the ASCB-EMBO 2019 meeting in Washington, DC. In this collection, we highlight cell biology papers in the areas of cell division and proliferation; cell migration; circadian clocks; and inflammation. If you perform research in these or related areas, we would be very interested in considering your work for publication. Please contact us at:

Research Articles

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Rozita Adib, Jessica M. Montgomery, Joseph Atherton, Laura O’Regan, Mark W. Richards, Kees R. Straatman, Daniel Roth, Anne Straube, Richard Bayliss, Carolyn A. Moores, and Andrew M. Fry

NEK family kinases target EML4 to ensure faithful chromosome alignment during metaphase.

CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration

Mallika Ghosh, Robin Lo, Ivan Ivic, Brian Aguilera, Veneta Qendro, Charan Devarakonda, and Linda H. Shapiro

The cell surface peptidase CD13 coordinates β1 integrin recycling to promote cell migration.

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

Olha M. Koval, Emily K. Nguyen, Velarchana Santhana, Trevor P. Fidler, Sara C. Sebag, Tyler P. Rasmussen, Dylan J. Mittauer, Stefan Strack, Prabhat C. Goswami, E. Dale Abel, and Isabella M. Grumbach

The mitochondrial Ca2+ uniporter enables ATP production to match energy demands during the cell cycle.

Desynchronization of the molecular clock contributes to the heterogeneity of the inflammatory response

Nancy C. Allen, Naomi H. Philip, Lucy Hui, Xu Zhou, Ruth A. Franklin, Yong Kong, and Ruslan Medzhitov

Differences in the phase of the circadian clock contribute to heterogeneity in the inflammatory response of macrophages.

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

Souvarish Sarkar, Dharmin Rokad, Emir Malovic, Jie Luo, Dilshan S. Harischandra, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Mechelle Lewis, Arthi Kanthasamy, and Anumantha G. Kanthasamy

Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure.

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