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Free Sample Articles from Science Signaling

This special collection of freely available Research Articles from Science Signaling is intended for those interested in the field of fibrosis research and the topics discussed at the Keystone Symposium on Fibrosis and Tissue Repair, 19 to 23 February, in Victoria, BC, Canada. In this collection, we highlight papers on cell-cell interactions and metabolic changes that promote fibrosis, as well as molecules that regulate fibrotic signaling. If you perform research in these or related areas, we would be very interested in considering your work for publication. Please contact us at:

Research Articles

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF–β

Monika Lodyga, Elizabeth Cambridge, Henna M. Karvonen, Pardis Pakshir, Brian Wu, Stellar Boo, Melanie Kiebalo, Riitta Kaarteenaho, Michael Glogauer, Mohit Kapoor, Kjetil Ask, and Boris Hinz

Adhesion with macrophages promotes the activation of fibroblasts into myofibroblasts and creates a self-sustaining profibrotic niche.

Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β

Xueqian Yin, Malay Choudhury, Jeong-Han Kang, Kyle J. Schaefbauer, Mi-Yeon Jung, Mahefatiana Andrianifahanana, Danielle M. Hernandez, Edward B. Leof

TGF-β–dependent metabolic dysregulation contributes to lung fibrosis.

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis

Brintha Selvarajah, Ilan Azuelos, Manuela Platé, Delphine Guillotin, Ellen J. Forty, Greg Contento, Hannah V. Woodcock, Matthew Redding, Adam Taylor, Gino Brunori, Pascal F. Durrenberger, Riccardo Ronzoni, Andy D. Blanchard, Paul F. Mercer, Dimitrios Anastasiou, Rachel C. Chambers

Through mTORC1 signaling, TGF-β1 stimulates glycine synthesis from glucose to support collagen production in lung fibroblasts.

Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Lisa M. Grove, Maradumane L. Mohan, Susamma Abraham, Rachel G. Scheraga, Brian D. Southern, James F. Crish, Sathyamangla V. Naga Prasad, Mitchell A. Olman

Profibrotic signaling by the mechanosensitive ion channel TRPV4 requires TRPV4-PI3Kγ complexes at the plasma membrane.

iRhom2 inhibits bile duct obstruction–induced liver fibrosis

Balamurugan Sundaram, Kristina Behnke, Andrea Belancic, Mazin A. Al-Salihi, Yasser Thabet, Robin Polz, Rossella Pellegrino, Yuan Zhuang, Prashant V. Shinde, Haifeng C. Xu, Jelena Vasilevska, Thomas Longerich, Diran Herebian, Ertan Mayatepek, Hans H. Bock, Petra May, Claus Kordes, Nima Aghaeepour, Tak W. Mak, Verena Keitel, Dieter Häussinger, Jürgen Scheller, Aleksandra A. Pandyra, Karl S. Lang, Philipp A. Lang

iRhom2 reduces hepatic stellate cell activation and liver fibrosis after bile duct ligation.

Special Edition Booklets

Download our “FREE” special edition booklets. These special edition booklets contain a collection of research articles from the Science Family of Journals.