Read our COVID-19 research and news.

Free Sample Articles from Science Immunology

Check out the Editors’ picks of COVID-19 papers published in Science Immunology! The Research Articles we’ve published to date cover a variety of topics including virus tropism and entry, the kinetics of T cell responses to SARS-CoV-2 epitopes, serology assays for diagnosis, and therapeutics to treat cytokine storm in hospitalized COVID-19 patients. The Focus commentaries discuss host-directed therapies for cytokine storm and use of SARS-CoV-2 antibody tests for seroepidemiology studies. Each Focus also features a customized figure crafted by the illustration team at AAAS in collaboration with the authors.

Research Articles and Reports

A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
Maria Pino et al.
Research Article | Science Immunology Date: 15-Jul-2021 DOI: 10.1126/sciimmunol.abh3634

CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients
Vamsee Mallajosyula et al.
Research Article | Science Immunology Date: 1-Jul-2021 DOI: 10.1126/sciimmunol.abg5669

Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients
Hector Rincon-Arevalo et al.
Research Article | Science Immunology Date: 15-Jun-2021 DOI: 10.1126/sciimmunol.abj1031

SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques
Carolina Garrido et al.
Research Article | Science Immunology Date: 15-Jun-2021 DOI: 10.1126/sciimmunol.abj3684

Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children
Marion Moreews et al.
Research Article | Science Immunology Date: 25-May-2021 DOI: 10.1126/sciimmunol.abh1516

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees
Daryl Geers et al.
Research Article | Science Immunology Date: 25-May-2021 DOI: 10.1126/sciimmunol.abj1750

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
Fiachra Humphries et al.
Research Article | Science Immunology Date: 18-May-2021 DOI: 10.1126/sciimmunol.abi9002

Pharmacological activation of STING blocks SARS-CoV-2 infection
Minghua Li et al.
Research Article | Science Immunology Date: 18-May-2021 DOI: 10.1126/sciimmunol.abi9007

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
Lina Ma et al.
Research Article | Science Immunology Date: 13-May-2021 DOI: 10.1126/sciimmunol.abh2259

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination
Rishi R. Goel et al.
Research Article | Science Immunology Date: 15-Apr-2021 DOI: 10.1126/sciimmunol.abi6950

SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
Sunil Kumar Saini et al.
Research Article | Science Immunology Date: 14-Apr-2021 DOI: 10.1126/sciimmunol.abf7550

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Bingyu Yan et al.
Research Article | Science Immunology Date: 7-Apr-2021 DOI: 10.1126/sciimmunol.abg0833

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19
Ryan S. Thwaites et al.
Research Article | Science Immunology Date: 10-Mar-2021 DOI: 10.1126/sciimmunol.abg9873

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
Benedikt Agerer et al.
Research Article | Science Immunology Date: 4-Mar-2021 DOI: 10.1126/sciimmunol.abg6461

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19
Laura A. Vella et al.
Research Article | Science Immunology Date: 2-Mar-2021 DOI: 10.1126/sciimmunol.abf7570

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients
Yu Zhao et al.
Research Article | Science Immunology Date: 23-Feb-2021 DOI: 10.1126/sciimmunol.abf6692

Prolonged evolution of the human B cell response to SARS-CoV-2 infection
Mrunal Sakharkar et al.
Research Article | Science Immunology Date: 23-Feb-2021 DOI: 10.1126/sciimmunol.abg6916

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8+ T cells
Anthony Kusnadi et al.
Research Article | Science Immunology Date: 21-Jan-2021 DOI: 10.1126/sciimmunol.abe4782

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection
Catherine J. Reynolds et al.
Research Article | Science Immunology Date: 23-Dec-2020 DOI: 10.1126/sciimmunol.abf3698

Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
Gemma E. Hartley et al.
Report | Science Immunology Date: 22-Dec-2020 DOI: 10.1126/sciimmunol.abf8891

Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome
Katharina Röltgen et al.
Research Article | Science Immunology Date: 7-Dec-2020 DOI: 10.1126/sciimmunol.abe0240

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
Baweleta Isho et al.
Research Article | Science Immunology Date: 8-Oct-2020 DOI: 10.1126/sciimmunol.abe5511

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients
Anita S. Iyer et al.
Report | Science Immunology Date: 8-Oct-2020 DOI: 10.1126/sciimmunol.abe0367

MAIT cell activation and dynamics associated with COVID-19 disease severity
Tiphaine Parrot et al.
Report | Science Immunology Date: 28-Sep-2020 DOI: 10.1126/sciimmunol.abe1670

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Elizabeth R. Mann et al.
Research Article | Science Immunology Date: 17-Sep-2020 DOI: 10.1126/sciimmunol.abd6197

Natural killer cell immunotypes related to COVID-19 disease severity
Christopher Maucourant et al.
Research Article | Science Immunology Date: 21-Aug-2020 DOI: 10.1126/sciimmunol.abd6832

SARS-CoV-2 seroprevalence among parturient women in Philadelphia
Dustin D. Flannery et al.
Report | Science Immunology Date: 29-Jul-2020 DOI: 10.1126/sciimmunol.abd5709

Comprehensive mapping of immune perturbations associated with severe COVID-19
Leticia Kuri-Cervantes et al.
Research Article | Science Immunology Date: 15-Jul-2020 DOI: 10.1126/sciimmunol.abd7114

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Jeong Seok Lee et al.
Research Article | Science Immunology Date: 10-Jul-2020 DOI: 10.1126/sciimmunol.abd1554

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome
Daniela Weiskopf et al.
Research Article | Science Immunology Date: 26-Jun-2020 DOI: 10.1126/sciimmunol.abd2071

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients
Lakshmanane Premkumar et al.
Research Article | Science Immunology Date: 11-Jun-2020 DOI: 10.1126/sciimmunol.abc8413

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19
Mark Roschewski et al.
Research Article | Science Immunology Date: 5-Jun-2020 DOI: 10.1126/sciimmunol.abd0110

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Ruochen Zang et al.
Research Article | Science Immunology Date: 13-May-2020 DOI: 10.1126/sciimmunol.abc3582

Focus and Perspective Commentaries; Editorials

Implications of defective immune responses in SARS-CoV-2 vaccinated organ transplant recipients
Peter S. Heeger et al.
Editorial | Science Immunology Date: 01-Jul-2021 DOI: 10.1126/sciimmunol.abj6513

Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England
Jonathan Sprent and Cecile King
Focus | Science Immunology Date: 22-Jun-2021 DOI: 10.1126/sciimmunol.abj9256

Complement control for COVID-19
Markus Bosmann
Focus | Science Immunology Date: 25-May-2021 DOI: 10.1126/sciimmunol.abj1014

The known unknowns of T cell immunity to COVID-19
Annika C. Karlsson et al.
Perspective | Science Immunology Date: 18-Nov-2020 DOI: 10.1126/sciimmunol.abe8063

SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection
Daniel M. Altmann and Rosemary J. Boyton
Perspective | Science Immunology Date: 17-Jul-2020 DOI: 10.1126/sciimmunol.abd6160

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward
Juliet E. Bryant et al.
Focus | Science Immunology Date: 19-May-2020 DOI: 10.1126/sciimmunol.abc6347

HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19
Francesca Romana Spinelli et al.
Focus | Science Immunology Date: 8-May-2020 DOI: 10.1126/sciimmunol.abc5367

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Check out the 2020 Editors’ picks of top articles published in Science Immunology this year!

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