Alnylam is leading the translation of RNA interference (RNAi) into an innovative new class of medicines which we believe have the potential to transform the lives of patients who have limited or inadequate treatment options. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach for the treatment of a wide range of debilitating diseases with high unmet medical need. Alnylam was founded in 2002 on a bold vision to turn scientific possibility into reality, which is now marked by its robust discovery platform and deep pipeline of investigational medicines, including 5 programs in late-stage clinical development. In 2018, our first medicine, ONPATTRO® (patisiran), became the world’s first approved RNAi therapeutic.
RNAi is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as “a major scientific breakthrough that happens once every decade or so,” and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines, known as RNAi therapeutics, is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of today’s medicines by potently silencing messenger RNA (mRNA) – the genetic precursors – that encode for disease-causing proteins, thus preventing them from being made. This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases.
Working at Alnylam
Alnylam employs over 1,200 people worldwide and is headquartered in Cambridge, MA. Alnylam is proud to have been recognized as one of The Boston Globe’s Top Places to Work five years in a row, one of Fast Company’s Most Innovative Companies in 2019 and has just emerged as a Great Place to Work® Best Workplaces for 2019 in Switzerland and the UK. We are growing quickly and hiring across North America, Europe, Asia, and Latin America for a wide variety of roles. We’re seeking smart, passionate, “change the world” kind of people who are ready to say, “challenge accepted.”