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Upgrading your recombinant protein expression: Expert advice on optimizing mammalian cell–based production

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Upgrading your recombinant protein expression: Expert advice on optimizing mammalian cell–based production

10 October 2018

12:00 p.m. ET

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The expression of recombinant proteins plays a pivotal role in the life sciences, with applications ranging from basic research to the production of biopharmaceuticals. Thus, it is critical to have an expression technology available that can provide suitable amounts of functional, high-quality recombinant protein in a reliable manner. In this webinar, our experts will discuss the key factors necessary for establishing and applying an efficient expression system based on Chinese hamster ovary (CHO) cells. Topics will include how to choose the best expression vector, host cell line, and selection system, as well as how to optimize the culture medium, growth conditions, and production process. Furthermore, we will highlight a variety of approaches to improve the productivity and reliability of CHO expression systems.

During the webinar, the speakers will:

  • Introduce the most critical factors for achieving successful recombinant protein expression
  • Offer advice on optimizing the most important variables for producing high-quality proteins at sufficient concentrations
  • Highlight pitfalls and challenges in the production workflow, and how they can be overcome
  • Answer your questions during the live broadcast!

This webinar will last for approximately 60 minutes.

Speaker bios

Christoph Zehe, Ph.D.

Sartorius Stedim Cellca GmbH
Laupheim, Germany

Dr. Zehe holds a doctorate in molecular and cell biology from the University of Heidelberg. In 2007, he joined Cellca GmbH (acquired by Sartorius Stedim Biotech SA in 2015 to form a new company, Sartorius Stedim Cellca GmbH), and developed the company’s proprietary expression vector system for Chinese hamster ovary (CHO) cells. Furthermore, he was instrumental in establishing a successful platform technology for the generation of high-expressing production cell lines. From 2011 to 2013, he was head of cell line development, in charge of all customer cell line development programs. In 2014 he was appointed head of technology development, where he set up Sartorius Stedim Cellca’s R&D department, focusing on improving the existing technology platform as well as developing new products. Since 2017, Dr. Zehe has held the position of lead scientist, responsible for innovation, intellectual property issues, and all R&D activities and programs at Sartorius Stedim Cellca GmbH.

Beate Stern, Ph.D.

UniTargetingResearch AS
Bergen, Norway

Dr. Stern is a cofounder of UniTargetingResearch AS, a biotech company located in Bergen, Norway, where she is chief scientific officer. She invented the UTR®Tech technology and resulting vector tools, which optimize the production of biologics/biosimilars in mammalian cells by ensuring efficient messenger RNA (mRNA) targeting and processing. Her expertise is based on many years of scientific research in the fields of molecular biology, cell biology, and bioinformatics. She is also an associate professor in the Department of Biomedicine at the University of Bergen, with a special interest in mRNA regulatory elements. Dr. Stern was previously a science journalist and was formerly affiliated with the Max Planck Institute of Biochemistry in Martinsried, Germany.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently Dr. Sanders is the Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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