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Untangling the tumor microenvironment: Illuminating the complex interactions and functions of immune cells

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Untangling the tumor microenvironment: Illuminating the complex interactions and functions of immune cells

Recorded 10 December 2014



Certain antibody therapies have demonstrated the potential for directing a patient’s own immune system against tumors. Further advances in this area will depend upon a detailed understanding of the tumor microenvironment and characterization of the location and status of immune cells and their interaction with tumor cells. This will require methods that provide phenotyping of immune and cancer cells combined with information about their spatial relationship in tumor regions. Additionally, a deeper understanding of the signaling cascades active in immune recognition of cancers is crucial. During this webinar, we will discuss the bringing together of multiplexed fluorescent immunohistochemistry, advanced microscopy techniques, and bioinformatics, and how these are now enabling new insights into cancer biology and immunology. 

During this webinar viewers will be able to ask questions of the panelists and will learn about:

  • Cutting-edge research targeting the B-cell receptor signaling pathway that has recently demonstrated therapeutic promise
  • Methods that can provide in depth information on cancer phenotypes, including simultaneous immunohistochemistry of multiple biomarkers, multiplexed imaging, single cell quantitative analysis, and automated phenotyping
  • How host-tumor interaction analysis in breast cancers could form the basis for assays to guide therapy and monitor response.

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Speaker bios

Scott J. Rodig, M.D., Ph.D.

DFCI/Brigham and Women’s Hospital
Boston, MA

Dr. Rodig is an alumnus of Washington University in St. Louis, where he completed both his M.D. and Ph.D. degrees. After undertaking postdoctoral and residency training at Harvard Medical School and Brigham and Women’s Hospital in Boston, Massachusetts, Dr. Rodig joined the faculty at Harvard Medical School in 2004. He is currently an associate professor in the pathology department, with strong interests in translational and clinical research in hematopathology and molecular pathology, with an emphasis on the development, validation, and implementation of new biomarkers to improve diagnostic practice. Dr. Rodig is also a consultant pathologist at the Dana Farber Cancer Institute and sits on the editorial board of the International Journal of Clinical and Experimental Pathology.

Edward C. Stack, Ph.D.

Hopkinton, MA

Dr. Stack completed his undergraduate education at Stony Brook University in Stony Brook, New York prior to his Ph.D. studies at Boston College in Chestnut Hill, Massachusetts. He carried out postdoctoral research at Boston University, where he began to develop his interests in human translational research. Dr. Stack has carried out many oncology studies examining disease mechanisms in multiple cancer types while at the Dana-Farber Cancer Institute, where he was the associate director of the Dana-Farber/Brigham and Women’s Center for Molecular Oncologic Pathology, and an instructor in the Pathology Department of Brigham and Women’s and the Harvard Medical School. Dr. Stack was also a member of the Dana-Farber/Harvard Cancer Center in both the gastrointestinal malignancies and prostate cancer research programs. Dr. Stack is currently a pathology scientist at PerkinElmer, where he is interested in developing cancer immunology-focused, tissue-based assays, which can provide deeper insights into cancer-host interactions and assist in clinical management of cancer.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently, Dr. Sanders is the Director and Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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