Immune systems are found in most living organisms. They reflect the common challenges of existing in a potentially hostile external environment, and often exhibit a complex, ever-changing interplay between specialized cell types, potent effector molecules, and exogenously acquired molecules and organisms. In our own immune systems, changes in the delicate homeostatic balance can lead to major problems, such as allergic responses or autoimmune diseases. Understanding how our immune system functions is difficult because of the plethora of different cell types and biomolecules involved, and because of its extremely dynamic nature. It is in constant coevolution with pathogens and must respond rapidly and specifically in each individual to a vast array of potential threats. Two major limitations of human immune system studies are their reliance on relatively few targeted assays and their potentially limited diversity within the samples examined. Studies that can provide genuine answers for immunological questions may require a systems biology approach that examines large numbers of different cell types and their interplay with real-time effector biomolecules, preferably using diverse sample cohorts. This webinar will focus on two such breakthrough studies (published in the journals Cell and Nature, respectively), which employ a broad, systems biology approach to better understand early postnatal immune system development, and the immunological control of latent infections.
During the webinar, the speakers will:
- Describe how combining approaches such as mass cytometry, protein biomarker discovery, and transcriptomics provides valuable insights into complex immunological systems
- Reveal how the immune system develops in newborn children, and the external factors that influence this process
- Offer new insights into the complex pathophysiology of latent infections with Mycobacterium tuberculosis, using a multi-omic, multicohort approach
- Answer your questions during the live broadcast!
This webinar will last for approximately 60 minutes.