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Reproducibility in crisis: Sample quality and the importance of early and ongoing analysis

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Reproducibility in crisis: Sample quality and the importance of early and ongoing analysis

Recorded 14 March 2018


There is a reproducibility crisis occurring in the life sciences that impacts all researchers, influencing the collection, analysis, and interpretation of their data. Recent surveys have shown that more than half of researchers struggle to reproduce not only the results of their fellow scientists, but their own experimental data as well. Irreproducible or questionable data can result in time-consuming, costly repetition of studies and, in some cases, misinterpreted or incorrect conclusions. One root cause of irreproducible results is a lack of understanding of the importance of sample quality. Running proper controls for sample quality is a necessary step in reducing questionable results, but this is often overlooked because of limited test material, lack of a convenient, comprehensive test, or pressure to meet rigorous deadlines. In this presentation, two experts will discuss the importance of understanding and monitoring sample quality, and how this can result in higher quality and more efficient, cost-effective research.

During the webinar, viewers will learn about:

•             The impact of the reproducibility crisis on the scientific community and other vested parties

•             Technologies that can easily be implemented into protein purification or characterization workflows to quickly analyze sample quality

•             The use of high-resolution crystallography methods to decipher protein structure and regulatory functions

•             The need to identify criteria and standards required to improve drug development and reduce the number of failed experiments.

Viewers can submit their questions to the panel during the live broadcast!

This webinar will last for approximately 60 minutes

Speaker bios

John P.A. Ioannidis, M.D., D.Sc.

Stanford University
Stanford, CA

Dr. Ioannidis holds the C.F. Rehnborg Chair in Disease Prevention at Stanford University, where he is Professor of Medicine, Professor of Health Research and Policy, and Professor (by courtesy) of Biomedical Data Science and of Statistics. He completed his undergraduate studies at Athens College in Greece and received his M.D. from the National University of Athens, where he also received a D.Sc. in biopathology. He then trained at Harvard Medical School and Tufts University School of Medicine (internal medicine and infectious diseases), and has held positions at the National Institutes of Health, Johns Hopkins University, and Tufts. He served as president for the Society for Research Synthesis Methodology and as an editorial board member of many leading journals (including PLOS Medicine, The Lancet, Science Translational Medicine, and PLOS ONE, among others), and as editor-in-chief of the European Journal of Clinical Investigation (2010–present). Dr. Ioannidis has worked in the fields of evidence-based medicine, clinical investigation, clinical and molecular epidemiology, clinical research methodology, empirical research methods, statistics, and genomics. He has a strong interest in meta-research, large-scale evidence (particularly randomized trials and meta-analyses), and appraisal and control of diverse biases in biomedical research. His PLOS Medicine paper “Why Most Published Research Findings are False” has been the most-accessed article in the history of the Public Library of Science (2.5 million hits).

Gregor Witte, Ph.D.

Ludwig Maximillian Universität
Munich, Germany

Dr. Witte completed his undergraduate degree in biochemistry and his Ph.D. in biochemistry/biophysical chemistry at Leibniz University of Hannover. His postdoctoral training was carried out at Hannover Medical School and then at the Ludwig-Maximilian University of Munich (LMU Munich), where he completed his habilitation in 2017. He is currently a research associate in structural biology and biophysical methods and a senior scientist at the Gene Center and Department of Biochemistry at LMU Munich. Based on his discovery of cyclic diadenosine monophosphate (c-di-AMP) as a novel bacterial cyclic dinucleotide messenger in 2008, Dr. Witte focuses his research on the structural biochemistry of c-di-AMP signaling in bacteria, cyclic dinucleotides in innate immune response, and the combination of orthogonal methods to characterize large molecular complexes.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently, Dr. Sanders is the Director and Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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