Post-translational modifications (PTMs)—including phosphorylation, acetylation, and ubiquitination—are specific modifications that can alter the activity of an individual protein target. The cumulative effect of these small modifications is the regulation of large signaling pathways and networks within cells.
Mass spectrometry is a powerful tool for the identification of individual PTMs during the investigation of signaling networks. A new approach using antibody-based peptide enrichment for a class of PTMs combined with tandem mass spectrometry has been successfully used for global identification of hundreds to thousands of PTMs within a sample. In this webinar, examples of how the technology was applied to each of these PTM classes will be described.
During this webinar, viewers will:
- Learn about post-translational modifications and their role in cellular signaling
- Discover how antibody-based proteomics approaches can be applied to identify, study, and characterize known and novel modifications
- Hear specific examples of how these approaches are being applied to the dissection of cellular signaling pathways, target identification, validation, and biomarker discovery by industry and academic experts
- Ask our expert panel questions in real time, during the broadcast
For related product or technology information, go to: www.cellsignal.com/cstwebinar