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Mining the transcriptome using spatial transcriptomics: Comprehensive 2D or 3D visualization of all mRNAs in tissue sections

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Mining the transcriptome using spatial transcriptomics: Comprehensive 2D or 3D visualization of all mRNAs in tissue sections

Recorded 06 June 2018


Some of the major challenges in research today include understanding disease progression and classifying diseases based on molecular markers. Obtaining quantitative information about gene-expression changes within cells in their native environment is laborious and challenging: Immunohistochemistry and in situ hybridization remain low throughput, nonquantitative technologies, while bulk sequencing does not reveal spatial information. However, methods that combine traditional histology with transcriptome data are already available or under development—some can capture the full transcriptome in a standard-size tissue section, while others focus on subsets of mRNAs with single-cell resolution. A new technology termed “spatial transcriptomics” uses spatially barcoded, complementary DNA primers for full-transcriptome capture on tissue sections, and can be applied alone or in combination with single-cell technologies. The method is easy to perform and is used by a rapidly growing number of academic institutions and pharmaceutical companies. 

This webinar will explore:

  • How spatial transcriptomics in individual tissue sections provides access to full-transcriptome data in 2D or 3D
  • Practical application and performance of the method in basic and medical research
  • How the technology can be used in combination with single-cell sequencing.

Viewers can ask questions during the live broadcast!

To learn more about products or technologies related to this webinar, go to https://spatialtranscriptomics.com/.

This webinar will last for approximately 60 minutes.

Speaker bios

Itai Yanai, Ph.D.

New York University
New York, NY

Dr. Yanai is a professor in the Department of Biochemistry and Molecular Pharmacology at New York University (NYU) School of Medicine in New York City. His research looks at dynamic biological processes through the lens of gene regulation. Using his training as an experimental embryologist, a molecular biologist, and an evolutionary and computational biologist, he is exploring how gene regulatory pathways are deployed at the molecular level. The Yanai lab carries out experiments at the level of individual cells and applies computational approaches to analyze the results. In 2012, the lab developed one of the first methods for single-cell RNA-Seq, called CEL-Seq, now recognized as the most sensitive and robust technique available for this procedure. The lab also developed a new method, scDual-Seq, for studying both host and pathogen transcriptomes at the single-cell level. Dr. Yanai is currently the inaugural director of NYU School of Medicine’s Institute for Computational Medicine, whose goal is to harness computational approaches for fundamental, medically relevant discoveries. He is also coauthor of the popular science book The Society of Genes, which discusses how genes compete and cooperate in our genome.

Jonas Frisén, M.D., Ph.D.

Karolinksa Institute
Solna, Sweden

Dr. Frisén has been the Tobias Foundation Professor of stem cell research at the Department of Cell and Molecular Biology at the Karolinska Institute (KI) in Stockholm, Sweden, since 2001. He is recognized for his studies of stem cells in adult organs, mainly the central nervous system. He has received several prestigious awards, was an advisor to the Swedish government on research, and is a member of the Nobel Assembly at KI. He was a founder of NeuroNova AB, a biotech company that initiated clinical studies with two new pharmaceuticals developed by the company for amyotrophic lateral sclerosis (ALS) and Parkinson’s disease, respectively, before being acquired by Newron Pharmaceuticals in 2012. Dr. Frisén is also chairman and cofounder of Spatial Transcriptomics.

Jackie Oberst, Ph.D.

Washington, D.C.

Dr. Oberst did her undergraduate training at the University of Maryland, College Park, and her Ph.D. in Tumor Biology at Georgetown University, Washington D.C. She combined her interests in science and writing by pursuing an M.A. in Journalism from the Philip Merrill College of Journalism at the University of Maryland, College Park. Dr. Oberst joined Science/AAAS in 2016 as the Assistant Editor for Custom Publishing. Before then she worked at Nature magazine, the Howard Hughes Medical Institute, The Endocrine Society, and the National Institutes of Mental Health.

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