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Keeping COVID-19 at bay: Existing and induced antibody immunity to SARS-CoV-2

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Keeping COVID-19 at bay: Existing and induced antibody immunity to SARS-CoV-2

04 August 2021

11:00 a.m. ET

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This webinar will be available to view in two different times zones: east and west. Please click the "Register now!" button to choose the date and time that best suits you.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel betacoronavirus causing Coronavirus disease 2019 (COVID-19). There is an urgent need to understand the humoral immune responses to SARS-CoV-2 and how they contribute to disease severity and vaccine-induced immunity. Humoral immune responses targeting SARS-CoV-2 viral antigens have been characterized by high-resolution mapping of the antibody responses in adults naturally infected with SARS-CoV-2, children and adults with no history of SARS-CoV-2 infection, and adults immunized with a two-dose COVID-19 messenger RNA (mRNA) vaccine. Most infected and vaccinated adults developed robust antibody responses (in order of prevalence: IgG>IgM>IgA) targeting spike (S) and nucleocapsid (N) proteins of the virus using multiplexed bead-based binding assays. Individuals who had prior infection, showed significantly higher antibody levels to SARS-CoV-2 after a single vaccine dose. While uninfected infants did not have high levels of SARS-CoV-2 cross-reactive antibodies, many children and adults had cross-reactive antibodies that recognize multiple viral antigens. These findings provide insights into SARS-CoV-2 antibody responses after infection, vaccination, and in unexposed populations of children and adults, which can facilitate future vaccine designs.

Our expert speaker, Todd Bradley, director of Immunogenomics at Children’s Mercy Research Institute in Kansas City, Missouri, will:

  • Provide an overview of serology tests, what they detect, and how this information can be used
  • Discuss the difference between existing and induced antibody immunity to SARS-CoV-2 and why antibody response rates differ among patients
  • Highlight differences in immune responses to vaccines in individuals with a history of prior COVID-19 infection
  • Answer your questions live during the broadcast.

This webinar will last for approximately 60 minutes.

Speaker bios

Todd Bradley, Ph.D.

Children’s Mercy Research Institute
Kansas City, MO

Dr. Bradley is director of Immunogenomics in the Genomic Medicine Center at the Children’s Mercy Research Institute, Children’s Mercy Hospital, in Kansas City, Missouri. He is also an assistant professor of pediatrics at the University of Missouri-Kansas City School of Medicine and assistant professor of pediatrics and pathology and laboratory medicine at the University of Kansas Medical Center. He is a pediatric genomic immunologist who directs a research laboratory determined to understand how immune responses are regulated in order to develop tools to engineer immunity. His lab uses genomic technologies to dissect the molecular and cellular mechanisms that shape the immune response and to discover how human genetics impact immunity, with the goal of improving vaccines and immunotherapies. Prior to joining Children’s Mercy, Dr. Bradley was assistant professor of medicine at the Human Vaccine Institute at Duke University Medical Center, in Durham, North Carolina.

Jackie Oberst, Ph.D.

Washington, DC

Dr. Oberst did her undergraduate training at the University of Maryland, College Park, and her Ph.D. in Tumor Biology at Georgetown University, Washington D.C. She combined her interests in science and writing by pursuing an M.A. in Journalism from the Philip Merrill College of Journalism at the University of Maryland, College Park. Dr. Oberst joined Science/AAAS in 2016 as the Assistant Editor for Custom Publishing. Before then she worked at Nature magazine, the Howard Hughes Medical Institute, The Endocrine Society, and the National Institutes of Mental Health.

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