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Investigating applications for humanized mouse models in preclinical research

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Investigating applications for humanized mouse models in preclinical research

Recorded 13 May 2021

Interviewee

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In an effort to understand human health and disease, researchers frequently make use of animal models. In the field of cancer research, mouse models are often the system of choice.  However, there are sufficient differences between humans and mice that interpretation of the results can be difficult and even inaccurate.  Endowing a mouse with a partially humanized immune system can go some way to circumventing this issue, providing a powerful tool for testing therapies against a variety of human diseases, including many cancers.
 
Join this conversation with Dr. Manfred Kraus, who will provide his personal take on the important role that humanized mouse models can play in preclinical research.

                                                     

For more information about The Jackson Laboratory and their humanized mouse models, please visit www.jax.org/humanized-mice.
[Music: Ice Climb/Podington Bear; Podcast editing and production: Podigy, Sean Sanders]

Speaker bio

Manfred Kraus, Ph.D.

Bristol Myers Squibb
Redwood City, CA

Dr. Kraus leads the in vivo pharmacology team at Bristol Myers Squibb (BMS) in Redwood City, California, with a focus on establishing pharmacokinetics/pharmacodynamics/efficacy relationships for drug candidates and improving translation of preclinical data into the clinic. His team supports the whole tumor microenvironment thematic research center portfolio from target identification to clinical proof of concept. He has focused on oncology/immuno-oncology and has led drug discovery projects with different modalities (kinase, metabolic, epigenetic modulators and small/large molecule, and antisense). Prior to BMS, he worked at Pfizer, AstraZeneca, Merck, and EMD Serono. Dr. Kraus earned his Ph.D. in the laboratory of Klaus Rajewsky at the University of Cologne, in Germany, followed by postdoctoral work at Harvard Medical School in Boston, Massachusetts, investigating the role of B-cell receptor signaling in mature B cells.

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