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A high-resolution look at the human cell: Introducing the Human Cell Atlas

This webinar is brought to you by the Science/AAAS Custom Publishing Office

A high-resolution look at the human cell: Introducing the Human Cell Atlas

Recorded 08 March 2017


Resolving the spatial distribution of the human proteome at a subcellular level greatly increases our understanding of human biology and disease. A high-resolution map of the human cell has been generated—part of the Human Protein Atlas database—that provides the in situ localization of 12,036 human proteins at a single-cell level, covering 30 subcellular structures, and enabling 14 major organelle proteomes to be defined. The high spatial resolution of the data has allowed the identification of novel protein components in all major organelles, as well as the characterization of fine cellular structures such as the cytokinetic bridge and nuclear bodies. An integrative approach to data generation includes strict validation criteria using gene silencing, paired antibodies, and fluorescently tagged proteins. The Cell Atlas reveals that approximately half of all proteins localize to multiple compartments and that many proteins show cell-to-cell variation in terms of protein abundance or spatial distribution. In this webinar, we will introduce the new Human Cell Atlas, outlining how it is being used to define the spatiotemporal organization of the human proteome at a subcellular level.

During the webinar, viewers will learn about:

  • The generation of the Human Cell Atlas and how its data was validated
  • The process for identification and characterization of the organelle proteomes
  • The identification and localization of proteins, particularly those showing complex distribution and cell-to-cell variations in expression.

This Webinar will last for approximately 60 minutes.

Speaker bios

Mathias Uhlén, Ph.D.

KTH Royal Institute of Technology
Stockholm, Sweden

Dr. Uhlén received his Ph.D. in chemistry at the Royal Institute of Technology (KTH) in Stockholm, Sweden. After postdoctoral training at the European Molecular Biology Laboratory in Heidelberg, Germany, he became professor of microbiology at KTH in 1988. Dr. Uhlén founded the Science for Life Laboratory in Stockholm, Sweden, where he served as director from 2010 to 2015, and has authored more than 750 publications in bioscience with a focus on the development and use of affinity reagents in biotechnology and biomedicine. He has founded 10 companies and has more than 70 patents and patent applications to his name. He is a member of the Royal Swedish Academy of Engineering Sciences, the Royal Swedish Academy of Sciences, the European Molecular Biology Organization, and the National Academy of Engineering, and is president of the European Federation of Biotechnology. He was the first to describe the use of affinity tags for purification of proteins and the use of biotin-streptavidin for DNA handling, methods now widely used in bioscience. He is leading the international effort to create the Human Protein Atlas with the aim of systematically mapping the entire human proteome. Dr. Uhlén has received numerous awards, including the AkzoNobel Science Award, the Seraphim Medal from His Majesty the King of Sweden, the HUPO Distinguished Achievement in Proteomic Sciences Award, and the ABRF Award for Outstanding Contributions to Biomolecular Technologies.

Emma Lundberg, Ph.D.

KTH Royal Institute of Technology
Stockholm, Sweden

Dr. Lundberg is currently the director of the Cell Atlas, part of the Swedish Human Protein Atlas program, and an elected member of the executive committee of the Human Proteome Organization. She heads the Cell Profiling group in the Department of Proteomics and Nanobiotechnology at the Royal Institute of Technology (KTH) in Stockholm, Sweden, where she is an associate professor. Her research is at the interface between bioimaging and proteomics, and aims to define the spatiotemporal organization of the human proteome at a subcellular level in an effort to understand how variations and deviations in localization contribute to cellular function as well as disease. To achieve this goal, her lab has developed technology platforms for large-scale immunostaining and systematic validation of antibody specificity, and has initiated citizen-science efforts to refine the Human Protein Atlas database. Dr. Lundberg received her Ph.D. in biotechnology from KTH in 2008.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently, Dr. Sanders is the Director and Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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