Building a detailed understanding of viral infection mechanisms and host immune response is critical to developing new treatments for infectious disease. The ability of innate immune cells to detect pathogens via sensing of foreign nucleic acids is a key first step in triggering immune signaling pathways for host defense. Research has revealed how specific DNA and RNA sensors are coupled to a cascade of immune responses, including the upregulation of transcriptional programs and the activation and release of mature cytokines. Pattern recognition receptors (PRRs), such as RIG-I and MDA5, detect viral RNAs during infection and activate the type I interferon signaling pathway. The mechanisms and signaling proteins that lie downstream of such nucleic acid sensors are crucial for host immune defense against many viruses, including SARS-CoV-2. However, these pathways are also vital for the immune system to distinguish self from nonself, so the regulation of these cascades and the inflammasome is a vital area of research in the development of treatments for autoimmune diseases and cancer. In this webinar, our speakers will discuss immune mechanisms of DNA and RNA sensing and the role these pathways play in host viral response as well as potential applications for these discoveries in therapy development.
During the webinar, viewers will:
- Learn how infection with viruses, such as SARS-CoV-2, activates the innate immune response
- Discover how pathogens can evade the innate immune response
- Gain insight into mechanisms of viral response by the innate immune system
- Have the opportunity to ask questions during the live broadcast.
This webinar will last for approximately 60 minutes.