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Deciphering epitranscriptomics: The importance of RNA modifications and RNA-binding proteins in disease

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Deciphering epitranscriptomics: The importance of RNA modifications and RNA-binding proteins in disease

14 November 2018

12:00 p.m. ET

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Epitranscriptomics refers to changes in an organism’s cells resulting from posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Uncovering the mechanisms underlying RNA modifications and RBP function are emerging frontiers in medicine that take the study of gene regulation a step beyond epigenetics. Recent research has identified over 100 distinct posttranscriptional RNA modifications. These modifications are hypothesized to have roles beyond simply fine-tuning the structure and function of RNA, and studies have linked them to various disease syndromes. Similarly, perturbations in the function of RBPs may disrupt RNA processing, thereby implicating them in the pathogenesis of several disease states.

During the webinar, viewers will:

  • Gain an understanding of the scope and mechanism of RNA modifications and RBP functions
  • Learn more about how RNA modifications and RBPs may be involved in the development of disease states
  • Hear about different approaches used to uncover mechanisms underlying RNA modifications and RBP function
  • Have an opportunity to put their questions to the panel during the live broadcast.

This webinar will last for approximately 60 minutes.

You can also view part 1, part 2 and part 3 of this series.

Speaker bios

Eugene Yeo, Ph.D.

University of California San Diego
San Diego, CA

Dr. Yeo received his B.S. in chemical engineering and his B.A. in economics from the University of Illinois at Urbana–Champaign. He completed his Ph.D. in computational neuroscience at the Massachusetts Institute of Technology (2005), and his MBA at the Rady School of Management at the University of California San Diego (UCSD) in 2008. In 2005, he was appointed the first Junior Fellow at the Crick-Jacobs Center for Theoretical and Computational Biology at the Salk Institute for Biological Studies in La Jolla, California. In 2008, he moved to UCSD as an assistant professor in the Department of Cellular and Molecular Medicine, where his lab studies genome-wide RNA processing and protein–RNA interactions in a variety of disease and developmental models. In 2014, he was promoted with tenure to associate professor and accelerated to full professor in 2016. Dr. Yeo is on the scientific advisory boards of several biotech companies, actively serves as a bioinformatics and business consultant, and is currently cofounder at four biotech startups. He is on the editorial board of the journals Cell Reports and Cell Research, and is also a visiting professor at the National University of Singapore. He was awarded the Alfred P. Sloan Research Fellowship in 2011 for his work in computational molecular biology and the inaugural Early Career Award in 2017 from the International RNA Society.

Chuan He, Ph.D.

University of Chicago
Chicago, IL

Dr. He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago. He received his B.S. degree in 1994 from the University of Science and Technology of China and his Ph.D. in chemistry from the Massachusetts Institute of Technology in 2000, studying under professor Stephen J. Lippard. After training as a Damon Runyon postdoctoral fellow with professor Gregory L. Verdine at Harvard University, he joined the University of Chicago as an assistant professor, rising to associate professor in 2008 and full professor in 2010. He was selected as an investigator for the Howard Hughes Medical Institute in 2013. Dr. He’s research spans many fields, including epigenetics, chemical biology, biochemistry, molecular biology, cell biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His laboratory has spearheaded the development of enabling technologies to study the biology of 5-hydroxymethylcytosine (5hmC) in mammalian genomes. In 2011, his group discovered reversible RNA methylation as a fundamental new mechanism of gene expression regulation at the posttranscriptional level.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently Dr. Sanders is the Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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