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Deciphering aging: Linking senescence with DNA damage and the cell cycle

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Deciphering aging: Linking senescence with DNA damage and the cell cycle

19 September 2018

12:00 p.m. ET

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Senescence describes the complex cellular response to stress that includes irreversible arrest of the cell cycle and thus prevention of the proliferation of defective or damaged cells. This effect makes senescence a key component in the body’s tumor suppression response and initialization of repair pathways, providing a health-promoting mechanism. Conversely, senescent cells can accumulate in the affected tissues of persons with age-related diseases such as dementias, arthritis, atherosclerosis, and others—such accumulation is considered a hallmark of aging that drives many age-related pathologies. These seemingly contradictory roles make cellular senescence an interesting research target for developing cancer suppression therapies as well as improving health maintenance and extending the human lifespan.

During this webinar, viewers will:

  • Gain insight into the processes by which senescent cells contribute to tumor suppression
  • Understand the impact of senescence on age-related dysfunction and chronic disease, and be introduced to potential therapies targeting
  • Have the opportunity to ask questions during the live broadcast!

This webinar will last for approximately 60 minutes.

You can also view part 1 and part 2 of this series.

Speaker bios

Sheila A. Stewart, Ph.D.

Washington University in St. Louis
St. Louis, MO

Dr. Stewart is a professor in the Department of Cell Biology and Physiology at Washington University School of Medicine in St. Louis and associate director for Basic Science at the Siteman Cancer Center. She received her Ph.D. in microbiology and immunology from the University of California, Los Angeles in 1997, and completed her postdoctoral fellowship in cancer biology at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology in Robert Weinberg’s laboratory. She is also an American Cancer Society Research Scholar. Dr. Stewart’s research is focused on understanding how age-related changes in the tumor microenvironment impact tumorigenesis. Her laboratory has shown that aged stromal cells, like cancer-associated fibroblasts, express a plethora of protumorigenic factors, and has developed murine models to explore the role of senescent stromal cells in tumorigenesis. A recent focus of the laboratory is examining how age-related changes in the premetastatic niche facilitate tumor cell seeding, dormancy, and outgrowth in the bone, and how these changes alter the local immune response to facilitate tumor cell proliferation.

James L. Kirkland, M.D., Ph.D.

Mayo Clinic
Rochester, MN

Dr. Kirkland is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism, director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic, and the Noaber Foundation Professor of Aging Research. His research covers cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities. He published the first article about drugs that clear senescent cells, known as senolytic agents. He is a scientific advisory board member for several companies and academic organizations and a member of the National Advisory Council on Aging of the U.S. National Institutes of Health, as well as president-elect of the American Federation for Aging Research and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently Dr. Sanders is the Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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