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Choosing the right NGS approach: WGS vs. WES vs. targeted sequencing

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Choosing the right NGS approach: WGS vs. WES vs. targeted sequencing

30 September 2020

12:00 p.m. ET

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As the expense of next-generation sequencing (NGS) has plummeted, whole-genome sequencing (WGS) has become increasingly attractive due to the large quantity of genetic information it reveals. However, challenges in obtaining sufficiently deep reads and in managing the extraordinary volume of data remain. Target-enrichment approaches—capturing specific subsets of the genome via hybridization with probes and subsequent isolation and sequencing—in conjunction with NGS offer attractive, less costly alternatives to WGS. In applications requiring greater sequencing depth than is practical with WGS, such as whole-exome sequencing (WES) and customized or disease-specific sequencing panels, this type of targeted sequencing approach focuses analysis on the most relevant genomic regions, although it runs the risk of missing crucial variants outside the targeted regions. In this webinar, we investigate the advantages and disadvantages of the multiple sequencing modalities available today, from WGS to WES to targeted sequencing. Choosing which approach to use depends largely on the scientific question being asked.

During this webinar the speakers will:

  • Discuss the relative pros and cons of WGS, WES, and targeted sequencing
  • Highlight specific situations in which each application offers the best solution for their particular sequencing needs
  • Answer viewer questions during the live broadcast.

This webinar will last for approximately 60 minutes.

Speaker bios

Shawn Levy, Ph.D.

Discovery Life Sciences
Huntsville, AL

Dr. Levy is chief scientific officer of genomics at Discovery Life Sciences in Huntsville, Alabama. He focuses on the development and application of genomic and bioinformatics technologies and methods to support scientific investigation. He is also a faculty investigator at the HudsonAlpha Institute for Biotechnology in Huntsville, an adjunct faculty member in the Department of Genetics and Department of Epidemiology at the University of Alabama at Birmingham, and serves as an ad hoc reviewer for more than a dozen scientific journals. He received his Ph.D. in biochemistry and completed a postdoctoral fellowship in genetics in 2000 at Emory University in Atlanta, where he set up a microarray facility at the Emory Center for Molecular Medicine. Before joining Discovery Life Sciences in 2009, Dr. Levy was a faculty member at Vanderbilt University Medical Center with appointments in the Department of Molecular Physiology and Biophysics and the Department of Biomedical Informatics. He was the founding director of the Vanderbilt Microarray Shared Resource.

Bob Fulton, M.S.

Washington University School of Medicine
St. Louis, MO

Mr. Fulton is an assistant professor of genetics at Washington University School of Medicine in St. Louis and director of Technical Development at the McDonnell Genome Institute (MGI). His role is to develop and deliver technologies and sequence-based solutions designed to answer a broad range of critical questions associated with the use of genomics in the clinical and research environments, based on his 25-plus years of experience in the generation of DNA sequence and analysis. Throughout his time at MGI, he has led the institute’s production-based targeted sequence efforts as well as the sequence improvement (finishing) pipelines responsible for genome sequence refinement. Mr. Fulton holds Bachelor’s (genetic engineering) and Master’s degrees, both from Southern Illinois University Edwardsville.

Jackie Oberst, Ph.D.

Washington, DC

Dr. Oberst did her undergraduate training at the University of Maryland, College Park, and her Ph.D. in Tumor Biology at Georgetown University, Washington D.C. She combined her interests in science and writing by pursuing an M.A. in Journalism from the Philip Merrill College of Journalism at the University of Maryland, College Park. Dr. Oberst joined Science/AAAS in 2016 as the Assistant Editor for Custom Publishing. Before then she worked at Nature magazine, the Howard Hughes Medical Institute, The Endocrine Society, and the National Institutes of Mental Health.

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