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Charting the human proteome: Understanding disease using a tissue-based atlas

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Charting the human proteome: Understanding disease using a tissue-based atlas

Recorded 18 March 2015



A decade on from the completion of the Human Genome, the Human Protein Atlas, a multinational research project supported by the non-profit Knut and Alice Wallenberg Foundation, recently launched (November 6, 2014) an open source tissue-based interactive map of the human proteome. A team of multidisciplinary researchers with expertise spanning biotechnology, information technology, and medicine have used a combination of several ‘omics technologies to map proteins down to the single cell level, showing both proteins restricted to certain tissues—such as the brain, heart, or liver—and those present in all tissues. It has taken this team over 1,000 person years to compile a searchable, open source database ( comprising 13 million annotated images of human tissues. The interactive database is aimed at researchers interested in basic research into human biology as well as those working in translational medicine. In this webinar, three of the researchers involved in this program will provide their insights regarding the lessons learned from this intensive effort to map the human proteome.

During the webinar, viewers will:

  • Gain a deeper understanding of the classification of the human proteome, including the tissue-specific proteome, the house-keeping proteome, and the druggable proteome
  • Learn the fundamentals of antibody-based protein profiling and the integration of proteomics and transcriptomics analyses
  • Have their questions answered live by the panelists!

The webinar will last approximately 60 minutes.

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Speaker bios

Mathias Uhlén, Ph.D.

KTH Royal Institute of Technology
Stockholm, Sweden

Dr. Uhlén received his Ph.D. in chemistry at the Royal Institute of Technology (KTH) in Stockholm, Sweden. After postdoctoral training at the European Molecular Biology Laboratory in Heidelberg, Germany, he became professor of microbiology at KTH in 1988. Dr. Uhlén founded the Science for Life Laboratory in Stockholm, Sweden, where he served as director from 2010 to 2015, and has authored more than 750 publications in bioscience with a focus on the development and use of affinity reagents in biotechnology and biomedicine. He has founded 10 companies and has more than 70 patents and patent applications to his name. He is a member of the Royal Swedish Academy of Engineering Sciences, the Royal Swedish Academy of Sciences, the European Molecular Biology Organization, and the National Academy of Engineering, and is president of the European Federation of Biotechnology. He was the first to describe the use of affinity tags for purification of proteins and the use of biotin-streptavidin for DNA handling, methods now widely used in bioscience. He is leading the international effort to create the Human Protein Atlas with the aim of systematically mapping the entire human proteome. Dr. Uhlén has received numerous awards, including the AkzoNobel Science Award, the Seraphim Medal from His Majesty the King of Sweden, the HUPO Distinguished Achievement in Proteomic Sciences Award, and the ABRF Award for Outstanding Contributions to Biomolecular Technologies.

Fredrik Pontén, M.D., Ph.D.

Uppsala University
Uppsala, Sweden

Dr. Pontén is a professor at Uppsala University and a board-certified physician and specialist in anatomical pathology. He received his Ph.D. in pathology at the Uppsala University and undertook his postdoctoral work as a Fulbright scholar at Yale University School of Medicine. Dr. Pontén has published nearly 200 scientific articles within the field of pathology and affinity proteomics. He holds a full professorship in the Clinical Department of Pathology at Uppsala University hospital, and is a member of the Royal Society of Sciences, the Swedish Society of Pathology, and co-founder of the Human Protein Atlas.

Cecilia Lindskog, Ph.D.

Uppsala University
Uppsala, Sweden

Dr. Lindskog is a researcher at Uppsala University who received her Ph.D. in pathology in the Department of Immunology, Genetics and Pathology at Uppsala University in 2013. Dr. Lindskog’s research focuses mainly on affinity proteomics and the analysis of expression patterns in normal and diseased tissues, using techniques such as RNA-seq, immunohistochemistry, and tissue microarrays. Dr. Lindskog is deputy site director of the tissue atlas and protein profiling division of the Human Protein Atlas, and also has experience in the biotechnology industry.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently, Dr. Sanders is the Director and Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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