Using mice as a model organism for human disease offers several advantages, including their more manageable size, rapid breeding cycle, and genetic and physiological similarity to humans. However, for therapies targeting specific aspects of the human immune system, such as natural killer cells and T cells, utilizing an in vivo model that recapitulates the specific aspects of the human immune system is a challenge. Although nude mice were previously used as the go-to model, better strains have recently been developed that enable researchers to study the effects of their therapeutic candidates. Humanized mice can engraft human hematopoietic stem cells or peripheral blood mononuclear cells (PBMCs) to yield models that can exhibit enhanced myeloid cell production or natural killer cell production. These mice present an innovative, cost-effective platform for simulating human trials (at lower cost), evaluating multiple drugs alone or in combination, and producing predicative/translationally relevant data. In this webinar, our experts will discuss how they have applied humanized mouse models in their work, providing insights into both the advantages and challenges of this research method.
During the webinar, the viewers will:
- Learn how to select the most optimal model for your research
- Explore specific models that have been engrafted with PBMCs
- Assess the human immune system function, including characterizing disease development and progression of graft-versus-host disease
- Be able to ask questions during the broadcast.
This webinar will last for approximately 60 minutes.