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The Brain Atlas: A road map through the complex protein signature of the brain

This webinar is brought to you by the Science/AAAS Custom Publishing Office

The Brain Atlas: A road map through the complex protein signature of the brain

20 November 2019

12:00 p.m. ET

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Speakers

Approximately 1 billion people in the world suffer from neurological disorders, defined as progressive loss of neurological functions, including dementia, stroke, multiple sclerosis, epilepsy, migraines, brain injuries, cancer, and neuroinfections. The neurodegenerative disorders include Alzheimer’s disease; the tremor-associated Parkinson’s disease, caused by death of dopaminergic neurons; amyotrophic lateral sclerosis, involving neuronal death and loss of motor function; the inherited disorder Huntington’s disease; and multiple sclerosis, an immune-mediated disorder affecting myelination of neuronal axons.

The Human Protein Atlas (www.proteinatlas.org) is an open-access database containing RNA and protein profiles of all genes across cells, tissues, and organs in the human body. The new Brain Atlas subsection contains genome-wide RNA profiles of all human protein–coding genes found in human, pig, and mouse brains. These profiles are complemented by antibody-based protein localization data collected for selected protein targets in the human and mouse brain.

During this webinar, the speakers will:

  • Introduce the Brain Atlas and how its data was generated
  • Discuss the process for identification and characterization of both brain- and regional-specific proteins and how they overlap
  • Explain the two different strategies for profiling proteins in the human and mouse brain
  • Answer viewer questions live during the broadcast.

This webinar will last for approximately 60 minutes.

Speaker bios

Evelina Sjöstedt, Ph.D.

KTH Royal Institute of Technology
Stockholm, Sweden

Dr. Sjöstedt is currently a postdoc in the Mulder/Uhlén lab at the Karolinska Institute, Stockholm, and has been instrumental in the development of the Brain Atlas. The Brain Atlas covers three different mammalian brains and maps gene expression in the different regions of the brain, and is combined with antibody-based spatial localization down to the single cell in human and mouse brain. The Atlas includes integrated data from multiple sources and methods—Dr. Sjöstedt hopes the Brain Atlas can bring neuroscientists and molecular biologists closer together by exploring various perspectives on brain research in one portal. She has worked in the Human Protein Atlas since 2008, starting in the Tissue Atlas, and then moving into the field of neuroscience. Dr. Sjöstedt received her Master’s in molecular biology at Uppsala University in 2008 and her Ph.D. in biotechnology at KTH Royal Institute of Technology in 2018.

Mathias Uhlén, Ph.D.

KTH Royal Institute of Technology
Stockholm, Sweden

Dr. Uhlén received his Ph.D. in chemistry at the Royal Institute of Technology (KTH) in Stockholm, Sweden. After postdoctoral training at the European Molecular Biology Laboratory in Heidelberg, Germany, he became professor of microbiology at KTH in 1988. Dr. Uhlén founded the Science for Life Laboratory in Stockholm, Sweden, where he served as director from 2010 to 2015, and has authored more than 750 publications in bioscience with a focus on the development and use of affinity reagents in biotechnology and biomedicine. He has founded 10 companies and has more than 70 patents and patent applications to his name. He is a member of the Royal Swedish Academy of Engineering Sciences, the Royal Swedish Academy of Sciences, the European Molecular Biology Organization, and the National Academy of Engineering, and is president of the European Federation of Biotechnology. He was the first to describe the use of affinity tags for purification of proteins and the use of biotin-streptavidin for DNA handling, methods now widely used in bioscience. He is leading the international effort to create the Human Protein Atlas with the aim of systematically mapping the entire human proteome. Dr. Uhlén has received numerous awards, including the AkzoNobel Science Award, the Seraphim Medal from His Majesty the King of Sweden, the HUPO Distinguished Achievement in Proteomic Sciences Award, and the ABRF Award for Outstanding Contributions to Biomolecular Technologies.

Jackie Oberst, Ph.D.

Science/AAAS
Washington, D.C.

Dr. Oberst did her undergraduate training at the University of Maryland, College Park, and her Ph.D. in Tumor Biology at Georgetown University, Washington D.C. She combined her interests in science and writing by pursuing an M.A. in Journalism from the Philip Merrill College of Journalism at the University of Maryland, College Park. Dr. Oberst joined Science/AAAS in 2016 as the Assistant Editor for Custom Publishing. Before then she worked at Nature magazine, the Howard Hughes Medical Institute, The Endocrine Society, and the National Institutes of Mental Health.

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