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Advances in Protein Expression: High Throughput Tools for Improving Analysis

This webinar is brought to you by the Science/AAAS Custom Publishing Office

Advances in Protein Expression: High Throughput Tools for Improving Analysis

Recorded 17 April 2013



The characterization of protein expression systems, particularly for biotherapeutics and structural biology, requires the testing of many variables to obtain the optimal clones. Assessing these variables—including expression system, cell culture, fermentation, and various media components such as growth factors—is costly and time intensive if done individually. However, high throughput analytical technologies and multi-use automation platforms can accommodate the high sample throughput necessary to provide fast, accurate, and efficient optimization of protein expression and purification conditions. This ultimately improves quality, mitigates risk, and accelerates the time to produce proteins for both research and therapeutics applications.

Join this webinar to learn from our experts about:

  • Factors to consider when planning expression system characterization experiments
  • Ways to identify and test for optimal culture conditions for expression of your particular recombinant protein
  • Adapting your experiments and workflow to incorporate high throughout analysis
  • And have your questions answered live during the webinar!


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Speaker bios

Brandan S. Hillerich, Ph.D.

Albert Einstein College of Medicine
Bronx, NY

Dr. Hillerich received his Ph.D. in molecular genetics from the University of Georgia, following which he joined the New York Consortium on Membrane Protein Structure, where he developed high throughput techniques for the expression and purification of integral membrane proteins. Dr. Hillerich is now the managing director of High Throughput Protein Production at the Albert Einstein College of Medicine where he oversees a production pipeline that services the New York Structural Genomics Research Consortium and the Enzyme Function Initiative, a program to determine the functions of unknown enzymes discovered through various genome projects. In the past two years, the facility produced over 24,000 clones and purified over 4,000 proteins, including over 500 expressed in insect or mammalian systems.

Jason Payne

Pfenex Inc.
San Diego, CA

Originally from the wheat fields of Washington State, Mr. Payne received his B.S. and Master’s degrees from the School of Molecular Biosciences at Washington State University. In 1999, he started his career with Dow Chemical, which had just begun a biotech effort in the San Diego area. It was there that Mr. Payne and his colleagues developed the Pfenex expression system, using Pseudomonas fluorescens strains. In late 2009, Dow spun out the company Pfenex based on this technology. Mr. Payne is an analytical scientist with a broad range of experience in a number of technologies, including laboratory automation, SDS-capillary gel electrophoresis, high-pressure liquid chromatography, and liquid chromatography-mass spectrometry.

Sean Sanders, Ph.D.

Washington, DC

Dr. Sanders did his undergraduate training at the University of Cape Town, South Africa, and his Ph.D. at the University of Cambridge, UK, supported by the Wellcome Trust. Following postdoctoral training at the National Institutes of Health and Georgetown University, Dr. Sanders joined TranXenoGen, a startup biotechnology company in Massachusetts working on avian transgenics. Pursuing his parallel passion for writing and editing, Dr. Sanders joined BioTechniques as an editor, before joining Science/AAAS in 2006. Currently, Dr. Sanders is the Director and Senior Editor for Custom Publishing for the journal Science and Program Director for Outreach.

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