PRIME-XV FreezIS DMSO-Free is a chemically defined cryopreservation solution for human mesenchymal stem/stromal cells (MSCs) free of dimethyl sulfoxide (DMSO) and animal-derived components. Amid growing concerns that DMSO may compromise the potency of MSCs, offering an effective DMSO-free cryoprotectant is an important addition to PRIME-XV product line. Researchers can now characterize cells in DMSO-free environments during basic and translational research, which may add valuable insight downstream and facilitate scale-up. PRIME-XV FreezIS DMSO-Free maintains the potency of MSCs throughout cryopreservation while sustaining comparable cell viability as solutions containing 10% DMSO. For applications where the effects of DMSO are not as critical, PRIME-XV FreezIS is offered as a 10% DMSO-containing, protein-free, chemically defined cryopreservation solution for a variety of cell types. Both cryopreservation solutions join the PRIME-XV line of cell therapy products, which are designed to offer the highest quality and performance for the culture of human stem cells and primary cells.