Xdrop from Samplix enables single-molecule resolution and bias-free enrichment of genomic regions longer than 100 kilobases from as little as 1 ng genomic DNA. It fits seamlessly with any sequencing platform and works equally well with both short-read and long-read sequencing systems. The Xdrop system builds on Samplix’ proprietary technologies to partition single molecules in easy-to-use microfluidics cartridges. The product comprises an Xdrop instrument for cartridge control, different microfluidics cartridges, and several molecular biology consumables optimized to work with the cartridges. Sample preparation is unique, as it provides for PCR-free enrichment of large single molecules spanning entire genomic regions. The long-range information may comprise phasing, structural variants, repetitive sequences, and more. Furthermore, as it requires very little knowledge of the target sequence, the Xdrop enrichment may also be applied to investigate uncharted genomic regions.