The SWISSCI Cryo-EM Grid Box is made from a special polymer formulation that ensures no static charging occurs at cryogenic temperatures. It has four diamond-shaped slot positions, each having its own number indicated on the side. No special tools are required, since the lid is rotated with standard laboratory tweezers. Individually numbered Pressure Adhesive Cryo Labels are supplied with the boxes, giving the consumer a convenient alternative to marking up each box themselves. The Cryo-EM Grid Box fits all common cryo-EM sample mounting and storage devices. Its low cost enables single use, giving each stored sample a unique identification number and preventing sample mix-ups.