The AMS Biotechnology cfPure DNA Extraction Kit provides an automation-friendly method to obtain maximal circulating cell-free DNA (cfDNA) recovery from various specimen types, including fresh or frozen serum or plasma as well as plasma from blood collected in Streck Cell-Free DNA collection tubes. The cfPure system uses silica-coated paramagnetic particles to purify cfDNA from less than 1 mL to greater than 10 mL of serum or plasma. The kit’s optimized buffers ensure efficient recovery of cfDNA fragments from 100 bp–500 bp. Recovered DNA is suitable for numerous downstream applications, including bisulfite sequencing, NGS, and quantitative PCR. Recently, DNA shed from tumor cells has been identified as a noninvasive method of screening biomarkers for the early diagnosis and prognosis of cancer. This method, sometimes called “liquid biopsy,” can provide guidance for treatment decisions, monitoring of cancer therapy, and organism-wide screening for the presence of nascent metastatic tumors in drug-treated cancer patients.