Assisting researchers in gaining a deeper understanding of dynamic biological processes, the new cellSens imaging software (version 1.12) ensures the most efficient use of valuable time-lapse experiments and the latest microscopy hardware. Building on the capabilities introduced by Olympus with its unique Graphical Experiment Manager (GEM) interface, cellSens 1.12 allows the user to truly get in touch with their sample. Enabling effortless setup of complex acquisition sequences and protocols, the GEM presents an intuitive method to seamlessly control motorized hardware, delivering outstanding ease and efficiency for advanced live cell imaging applications. In cellSens 1.12, the GEM has further evolved to maximize the efficiency of multicolor z-stacking experiments. Prioritizing the use of fast devices such as piezometric z-axis modules reaches a new level of imaging speed, with the freedom to choose the sequence of motorization movements. Enhancing the efficiency of time-lapse applications, the improved GEM also enables investigations into short-term dynamics and long-term sample evolution side by side.