Let’s celebrate! Science Translational Medicine launched in 2009 with the aim of publishing biomedical research at all stages of translation, from the bench to the bedside and back again. In honor of our 10^th anniversary in 2019, we commissioned a monthly Focus series entitled “Science Transforming Medicine” to commemorate progress made in biomedicine over the past decade. Many of today’s clinical realities were at an early, preclinical stage when the journal launched in 2009; other promising approaches failed to come to fruition despite a decade of work. Science Transforming Medicine highlights important advances in translational research fields achieved over the past decade, and also looks forward to the future. This series authored by field experts features papers published in Science Translational Medicine during the early years of the journal. Focus articles discuss how the field, therapy, or topic covered in those early Science Translational Medicine papers advanced over the past decade, as well as barriers still to be surmounted to translate advances into improved treatments for patients. This Focus series spans all areas of biomedicine, from liquid biopsies to bioelectronics. Access the Science Transforming Medicine booklet here and the twelve individual Focus articles below:

Advances in clinical MRI technology
Mukesh G. Harisinghani, Aileen O’Shea, and Ralph Weissleder
Journal Article | Sci. Transl. Med. Date: 18-Dec-2019 DOI: 10.1126/scitranslmed.aba2591

Promising disease-modifying therapies for Parkinson's disease
Valina L. Dawson and Ted M. Dawson
Journal Article | Sci. Transl. Med. Date: 27-Nov-2019 DOI: 10.1126/scitranslmed.aba1659

Multiple roles for HIV broadly neutralizing antibodies
Barton F. Haynes, Dennis R. Burton, and John R. Mascola
Journal Article | Sci. Transl. Med. Date: 30-Oct-2019 DOI: 10.1126/scitranslmed.aaz2686

Wrangling RNA: Antisense oligonucleotides for neurological disorders
Kevin Talbot and Matthew J. A. Wood
Journal Article | Sci. Transl. Med. Date: 25-Sep-2019 DOI: 10.1126/scitranslmed.aay2069

Applications of liquid biopsies for cancer
Austin K. Mattox, Chetan Bettegowda, Shibin Zhou, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein
Journal Article | Sci. Transl. Med. Date: 28-Aug-2019 DOI: 10.1126/scitranslmed.aay1984

Conformable bioelectronic interfaces: mapping the road ahead
Giuseppe Schiavone and Stéphanie P. Lacour
Journal Article | Sci. Transl. Med. Date: 31-Jul-2019 DOI: 10.1126/scitranslmed.aaw5858

A decade of digital medicine innovation
Eric J. Topol
Journal Article | Sci. Transl. Med. Date: 26-Jun-2019 DOI: 10.1126/scitranslmed.aaw7610

Depicting brighter possibilities for treating blindness
José-Alain Sahel, Jean Bennett, and Botond Roska
Journal Article | Sci. Transl. Med. Date: 29 May-2019 DOI: 10.1126/scitranslmed.aax2324

Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine
Steven A. Porcelli and William R. Jacobs Jr.
Journal Article | Sci. Transl. Med. Date: 01 May-2019 DOI: 10.1126/scitranslmed.aax4219

Advances in artificial pancreas systems
Charlotte K. Boughton and Roman Hovorka
Journal Article | Sci. Transl. Med. Date: 20-Mar-2019 DOI: 10.1126/scitranslmed.aaw4949

Driving CAR T cell translation forward
Liora Schultz and Crystal Mackall
Journal Article | Sci. Transl. Med. Date: 27-Feb-2019 DOI: 10.1126/scitranslmed.aaw2127

Transforming medicine with the microbiome
Niv Zmora, Eliran Soffer, Eran Elinav
Journal Article | Sci. Transl. Med. Date: 30-Jan-2019 DOI: 10.1126/scitranslmed.aaw1815