The human brain has evolved to give rise to many unique traits. Its function and development are regulated by complex genetic systems. However, psychiatric disease is also a facet of humanity that can arise during development from changes in the genome or epigenome in ways that may affect gene regulation and expression. Here, the PsychENCODE Consortium presents 11 research papers published in Science, Science Advances, and Science Translational Medicine organized around the themes of functional genomics in the developing and adult brain along with examinations of psychiatric disorders. Studies of over 2000 individual brains with bulk tissue analysis and at the single cell level provide a rich resource for studies of gene expression, epigenetics, and genomic regulation to better understand the neurogenetics underlying development, health, and disease.
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Integrative functional genomic analysis of human brain development and neuropsychiatric risk
Li et al.
Journal Article | Science Date: 14-Dec-2018 DOI: 10.1126/science.aat7615
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Gandal et al.
Journal Article | Science Date: 14-Dec-2018 DOI:10.1126/science.aat8127
Comprehensive functional genomic resource and integrative model for the human brain
Wang et al.
Journal Article | Science Date: 14-Dec-2018 DOI: 10.1126/science.aat8464
Spatiotemporal transcriptomic divergence across human and macaque brain development
Zhu et al.
Journal Article | Science Date: 14-Dec-2018 DOI: 10.1126/science.aat8077
Transcriptome and epigenome landscape of human cortical development modeled in organoids
Amiri et al.
Journal Article | Science Date: 14-Dec-2018 DOI: 10.1126/science.aat6720
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
Rajarajan et al.
Journal Article | Science Date: 14-Dec-2018 DOI:10.1126/science.aat4311
Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder
An et al.
Journal Article | Science Date: 14-Dec-2018 DOI: 10.1126/science.aat6576
Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation
Suhn K. Rhie, Shannon Schreiner, Heather Witt , Chris Armoskus, Fides D. Lay, Adrian Camarena, Valeria N. Spitsyna, Yu Guo , Benjamin P. Berman, Oleg V. Evgrafov , James A. Knowles, Peggy J. Farnham
Journal Article | Science Advances Date: 14-Dec-2018 DOI: 10.1126/sciadv.aav8550
The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders
Chao Chen, Qingtuan Meng, Yan Xia, Chaodong Ding, Le Wang, Rujia Dai, Lijun Cheng, Preethi Gunaratne, Richard A. Gibbs, Shishi Min, Cristian Coarfa, Jeffrey G. Reid, Chunling Zhang, Chuan Jiao, Yi Jiang, Gina Giase, Amber Thomas, Dominic Fitzgerald, Tonya Brunetti, Annie Shieh, Cuihua Xia, Yongjun Wang, Yunpeng Wang, Judith A. Badner, Elliot S. Gershon, Kevin P. White, Chunyu Liu
Journal Article | Science Translational Medicine Date: 14-Dec-2018 DOI: 10.1126/scitranslmed.aat8178
The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes
Qingtuan Meng, Kangli Wang, Tonya Brunetti, Yan Xia, Chuan Jiao, Rujia Dai, Dominic Fitzgerald, Amber Thomas, Lindsey Jay, Heather Eckart, Kay Grennan, Yuka Imamura-Kawasawa, Mingfeng Li, Nenad Sestan, Kevin P. White, Chao Chen, Chunyu Liu
Journal Article | Science Translational Medicine Date: 14-Dec-2018 DOI: 10.1126/scitranslmed.aat6912
A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons
Alexey Kozlenkov, Junhao Li, Pasha Apontes, Yasmin L. Hurd, William M. Byne, Eugene V. Koonin, Michael Wegner, Eran A. Mukamel, and Stella Dracheva
Journal Article | Science Advances Date: 26-Sept-2018 DOI: 10.1126/sciadv.aau6190