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Science Advances Special Collection—Addiction: Advances in Treatment and Recovery

Substance use disorder (SUD) — also commonly referred to as addiction — is a medical illness associated with compulsive and repeated use of addictive substances.  SUDs affect the lives of millions of people worldwide and are among the leading causes of preventable deaths and life with disability. Social and economic costs related to SUDs are enormous. Although there are medications and other treatment methods, the effectiveness of SUDs treatment and of sustaining recovery remains a daunting challenge. Current resources and available scientific knowledge to help individuals with SUDs are both underutilized and insufficient. Successful treatment and recovery from SUDs requires not only the determination of affected individuals, but also concerted and continuous efforts from medical professionals, social and scientific communities, and governmental actions.   

This Special Collection on Addiction of open access articles, curated by Science Advances editors, Dr. Benjamin Xu and Dr. Kevin LaBar, focuses on scientific advances in the treatment and recovery mechanisms of addiction related to four widely misused substances: alcohol, nicotine, cocaine, and opioids. All of these substances continue to have a profound global impact on health and well-being and on social and economic resources. This collection includes comprehensive review articles on these substances authored by leading researchers in the field of addiction, along with research studies that present recent discoveries with clear translational impact on developing new treatment targets and effective intervention strategies.  We hope this Special Collection on Addiction will facilitate the effort in advancing the treatment and recovery process of SUDs. 


Advances in understanding addiction treatment and recovery

Benjamin Xu & Kevin LaBar

Editorial | Science Advances | 16-Oct-2019 | DOI: 10.1126/sciadv.aaz6596


Advances in the Science and Treatment of Alcohol Use Disorder

Katie Witkiewitz, Raye Z. Litten & Lorenzo Leggio

Review Article | Science Advances | 25-Sep-2019 | DOI: 10.1126/sciadv.aax4043


Current Status of Opioid Addiction Treatment and Related Preclinical Research

Mary Kreek, Brian Reed & Eduardo Butelman

Review Article | Science Advances | 02-Oct-2019| DOI: 10.1126/sciadv.aax9140


The Treatment of Cocaine Use Disorder

Kyle Kampman

Review Article | Science Advances | 16-Oct-2019 | DOI: 10.1126/sciadv.aax1532


Current Advances in Research in Treatment and Recovery: Nicotine Addiction

Judith J. Prochaska & Neal Benowitz

Review Article | Science Advances | 16-Oct-2019 | DOI: 10.1126/sciadv.aay9763


Acupuncture attenuates alcohol dependence through activation of endorphinergic input to the nucleus accumbens from the arcuate nucleus

Chang, S. et al.

Research Article | Science Advances | 04-Sep-2019 | DOI: 10.1126/sciadv.aax1342


Habenular and Striatal activity during performance feedback is differentially linked with state-like and trait-like aspects of tobacco

Flanner, J. S. et al.

Research Article | Science Advances | 09-Oct-2019 | DOI: 10.1126/sciadv.aax2084


Microglia Morphology and Pro-Inflammatory Signaling in the Nucleus Accumbens during Nicotine Withdrawal

Adeluyi, A. et al.

Research Article | Science Advances | 09-Oct-2019 | DOI: 10.1126/sciadv.aax7031


Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving

Werner, C. et al.

Research Article | Science Advances | 09-Oct-2019 | DOI: 10.1126/sciadv.aay0351


Mindfulness-Oriented Recovery Enhancement Remediates Hedonic Dysregulation In Opioid Users: Neural and Affective Evidence of Target Engagement

Garland, E. et al.

Research Article | Science Advances | 16-Oct-2019 | DOI: 10.1126/sciadv.aax1569

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