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Careers in Clinical and Translational Research

From 2008 through 2011, with generous support from the Burroughs Wellcome Fund, Science Careers posted some 60+ articles focused on careers in clinical and translational research. Since then, we have continued to update the collection with new articles. This cache of articles and podcasts remains, we believe, the best single source of information about careers in these important scientific fields.

Working in the Community to Reduce Health Disparities, by Jennifer Carpenter, 28 March 2014. Kristi Allgood and her Chicago-based colleagues are working in the community to reduce breast cancer mortality in African-American women.

Finding Nirvana: Paths to Becoming a Physician-Scientist, by Aimee S. Payne, Skip Brass, 16 October 2013. It takes a long time to become a physician-scientist, but once you've arrived the career is very rewarding.

Career Q&A: Michael Yaffe, by Trisha Gura, 10 May 2013. The systems biologist and trauma surgeon talks about treating patients after the Boston Marathon bombings and about his career.

Career Q&A: Myron Cohen, by Beth Mole, 23 March 2012. The infectious disease expert and recipient of Science's 2011 Breakthrough of the Year award reflects on his career and keys to success.

Your Research, Their Hope, by Michael Price, 09 March 2012. Scientists working with patient-advocacy groups need to set legal and ethical guidelines so interactions can be mutually beneficial.

Perspective: Bridging Your Research into Public Health, by Kee Chan, 17 February 2012. A public health researcher and former bench scientist offers advice on how to implement your science in the real world.

Genetic Engineering on Steroids, by Vijaysree Venkatraman, 20 January 2012. Synthetic biologist Ron Weiss has moved from programming computers to programming cells.

Translational Research in Early-Childhood Education, by Siri Carpenter, 19 August 2011. Two researchers combine neuroscience and education to discover interventions for children with learning difficulties.

From Mycology to Oncology, by Rachel Kaufman, 05 August 2011. Wilma Lingle started out studying mushrooms but transformed herself into a Mayo Clinic breast cancer researcher and the manager of two core facilities.

A Farmer's Son Cultivates a Career in Translational Research , by Chelsea Wald, 08 July 2011. Molecular geneticist Robert Kralovics traces his character as a scientist to growing up as a farmer's son in a Communist regime.

Podcast: Training Translational Scientists, by Kate Travis, 10 June 2011. CTSciNet, the Clinical and Translational Science Network, teamed up with Science Translational Medicine for a podcast on fostering a translational medicine workforce.

Focus on Aging: Unlocking the Genome's Secrets to Long Life, by Mitch Leslie, 06 May 2011. Postdoc Liz Cirulli started out in plant genetics but now co-leads Duke's Centenarian Project, which aims to find gene variants that account for the longevity of centenarians.

Q&A: Taking Mathematics to Heart, by Kate Travis, 29 April 2011. Mathematician John Wesley Cain works with clinicians, physicists, and engineers in a field called cardiac electrophysiology.

Transcript: An Interview With Clinician-Investigator David Solit, by Kate Travis, 22 April 2011. Read the full transcript of an interview with clinician-investigator David Solit of Memorial Sloan-Kettering Cancer Center in New York.

Learning How to Conduct Cancer Clinical Trials, by Karyn Hede, 25 March 2011. Training courses outline the challenges and opportunities in conducting cancer clinical trials.

Q&A: Finding and Exploiting Cancer's Weaknesses, by Kate Travis, 25 March 2011. Clinician-investigator David Solit studies the genetic basis of cancer tumors and looks for novel therapies that target specific mutations.

A Zigzagging Path Points Straight to Success, by Geoffrey Koch, 4 March 2011. Patricia Beckmann's career is one long lesson in how to succeed in science.

Sharing Data in Biomedical and Clinical Research, by Kate Travis, 11 February 2011. It's not always clear how or where to share clinical data in a way that protects patients' privacy.

More Than Words, by Chelsea Wald, 11 February 2011. Biomedical ontology is growing as an informatics specialty, and ontologies are proving to be powerful software and data-mining tools.

A Loyal Fan of Women's Health Research, by Karyn Hede, 28 January 2011. Physician-scientist Rebecca Jackson's enthusiasm for research is matched only by her passion for Ohio State football.

From Elephants to People: A Veterinary Scientist's Unique Career Path, by Sarah Webb, 14 January 2011. D.V.M.-Ph.D. Laura Richman's discovery of a novel elephant herpesvirus led to a career in human translational medicine.

Engineering Solutions to Biomedical Problems, by Nancy Volkers, 17 December 2010. There are many ways that classically trained engineers can work at the interface of engineering and medicine.

Perspective: Residency 101 for Physician-Scientists, by Robin G. Lorenz, 26 November 2010. Future physician-scientists should ask three questions when choosing a residency: What field? What type of residency? Which program?

Working With Industry Under a Microscope, by Karyn Hede, 12 November 2010. Regulations seem to discourage academic scientists from partnering with industry, but such collaboration is essential to translational research.

Ghostwriters in the Medical Literature, by Susan Gaidos, 12 November 2010. Despite new disclosure requirements, ghostwriters remain a threat to the integrity of the scientific literature as well as careers.

Environmental Exposures Shape Human Health -- and Careers, by Lisa Seachrist Chiu, 29 October 2010. Brown University scientist Carmen Marsit's unique training allows him to take an interdisciplinary and translational approach to epigenetics.

Opening New Research Avenues in Epigenetics, by Elisabeth Pain, 29 October 2010. Epigenetics provides a common theme to Spanish cancer researcher Manel Esteller's broad interests in basic and translational research.

Perspective: Top 10 Tips for Mentors, by Philip S. Clifford and Joan M. Lakoski, 8 October 2010. Being an effective mentor requires being a good listener, setting boundaries, providing support and criticism, and celebrating milestones.

Audio: Transdisciplinarity is Key in Translational Research, by Kate Travis, 24 September 2010. One factor common to scientists working in all parts of the translational realm is the ability to truly collaborate with people across disciplines. Listen to four scientists at a 2009 workshop organized by Science Careers discuss their own transdisciplinary approach.

Perspective: Building a Team Science Training Program, by Daisy Grewal, 10 September 2010. The Career Development and Diversity Center at Stanford University learned valuable lessons about designing a team science training program.

Making Team Science Work: Advice From a Team, by Karyn Hede, 27 August 2010. A long-term commitment and a supportive environment allow the Yale School of Medicine melanoma research group to excel.

From the Nobel Prize to Third World Medicine: An Interview With Peter Agre, by Kate Travis, 25 August 2010. Physician-scientist Peter Agre discusses science diplomacy in an editorial in this week's Science Translational Medicine. He recently spoke to Science Careers about his career, research, and path to science advocacy and Third World medicine.

Scientist's Work Bridges Math and Cancer, by Sarah A. Webb, 13 August 2010. Franziska Michor's research skills involve equations and computers, but her goal is clinical: to eliminate cancer.

Answering Biomedical Questions with Information Technology, by Nancy Volkers, 30 July 2010. Harvard Medical School physician-scientist Lynn Bry has developed an informatics system for matching biological samples to research needs.

Veterinarian Scientists Bring Unique Perspectives to Translational Research, by Lisa Seachrist Chiu, 16 July 2010. D.V.M.-Ph.D.s are uniquely qualified to do research in animal models and translate findings across species -- including humans.

Psychologist Bridges Clinic and Lab to Untangle Schizophrenia's Roots by Brian Vastag, 18 June 2010. Deanna Barch is developing neuroimaging tools to speed the development of schizophrenia treatments.

Designing a Career in Biomedical Engineering by Elisabeth Pain, 11 June 2010. Engineers, biologists, mathematicians, physicists, and chemists all contribute to the development of medical devices.

Perspective: The Successful Physician-Scientist of the 21st Century by Andrew I. Schafer, 28 May 2010. Physician-scientists must learn to thrive, despite a divided culture and rigid institutional structures.

In Person: Studying the Implications of New Medical Technologies by Wendell S. Fortson, 14 May 2010. People with scientific training are needed to explore ethical and legal issues of science in the clinic.

Translating the Puzzle of Autism into Treatment by Sarah A. Webb, 23 April 2010. A complex fabric of researchers work to understand and treat autism.

All in the Details: Careers in Regulatory Science by Nancy Volkers, 9 April 2010. Some scientists go to great lengths to make everything they do in the lab transparent.

Podcast: Training Translational Scientists, by Kate Travis, 7 April 2010. This week, CTSciNet, the Clinical and Translational Science Network, teamed up with Science Translational Medicine for a podcast on fostering a translational medicine workforce.

A Shifting Drug Industry Means New Opportunities in Translational Research, by Lisa Seachrist Chiu, 26 March 2010. Despite layoffs, pharmaceutical companies are hiring researchers to strengthen their early drug-development programs.

New Opportunities and Jobs to Come in Comparative Effectiveness Research by Karyn Hede, 12 March 2010. Recovery Act funding will boost a field focused on health care costs and quality.

The Team Science Revolution, by Kate Travis, 11 March 2010. A commentary published this week in Science Translational Medicine takes on the issue of multidisciplinary team science. Lead author Nora Disis spoke with Science Careers about the topic.

For Physician-Scientist Couple, Success is in Balance by Kate Travis, 26 February 2010. Deepali Kumar and Atul Humar say their shared specialty helps them balance work and family life.

Informatics Careers Take Shape in Translational and Clinical Research by Brian Vastag, 22 January 2010. Electronic patient data and research repositories mean new opportunities in medical informatics.

A Scientist's Infectious Enthusiasm by Sarah A. Webb, 1 January 2010. Benjamin tenOever is an unconventional virologist who is working to make his discoveries clinically relevant.

Translating Lupus Research by Karyn Hede, 4 December 2009. An encounter with a lupus patient crystallized one scientist's concept of "translational research" and fundamentally changed the focus of her lab.

A Recipe for Collaboration by Lisa Seachrist Chiu, 13 November 2009. Serendipity, hard work, and good communication formed the core of an unlikely collaboration that resulted in a new technique for measuring hormone levels.

Perspective: Three Crucial Questions When Applying to M.D.-Ph.D. Programs by Skip Brass, 16 October 2009. Is an M.D.-Ph.D. program right for me? Where should I apply? Where should I go?

Questions and Answers: Pursuing an M.D.-Ph.D. by the Association of American Medical Colleges, 14 October 2009. This guide, adapted from AAMC, provides answers to frequently asked questions about M.D.-Ph.D. programs.

Destigmatizing Depression by Karyn Hede, 2 October 2009. Medical students and physician-scientist trainees suffer from high rates of depression and often are reluctant to admit to their condition.

A Physician-Researcher Thrives in the Balance by Chelsea Wald, 11 September 2009. Regan Theiler balances her clinical work in the delivery room with lab research on infectious diseases.

Dealing With Debt by Karyn Hede, 28 August 2009. Education debt can make it difficult for physician-scientists to stay on a research course.

Top 10 Tips to Maximize Your Mentoring by Joan Lakoski, 14 August 2009. Cultivating and nurturing your mentoring relationships are essential, particularly in the complex landscape of clinical and translational research.

Basic Scientists in the Clinic by Brian Vastag, 10 July 2009. Opportunities for Ph.D. scientists to interact with patients appear to be growing.

Perspective: Speed Networking for Scientists by Louise Holmes, 12 June 2009. Speed networking can be an effective way to promote new research collaborations.

Traversing the Bridge Years – Advice for Future Physician Scientists by Skip Brass, 15 May 2009. Crossing the bridge between clinical training and a research career requires careful, early, strategic thinking.

CTSciNet Resources by Science Careers Staff, 15 May 2009. A collection of career resources for clinical and translational scientists and trainees.

CTSciNet and "Translational Careers" by Science Careers Staff, 15 May 2009. Thirteen leaders of a diverse range of organizations join forces on an editorial.

For Med Students, Research Training Opportunities Abound by Lisa Seachrist Chiu, 1 May 2009. Year-out programs and research time within the medical school curriculum offer students a taste of research.

Making Room for Research During Residency by Karyn Hede, 10 April 2009. Research residencies give physician-scientists protected time for research during their clinical training.

Bringing Community Into Translational Research by Sarah Webb, 20 March 2009. Translational social scientists adapt research for the people it aims to serve and carry the lessons they learn in the community back to the lab.

Redefining Tenure at Medical Schools by Chelsea Wald, 6 March 2009. Fewer faculty jobs are tenure-track, but job seekers in academic medical research need to look beyond the tenure-track label.

Perspective: Problem Finding and the Multidisciplinary Mind, by Linda Austin, 20 February 2009. Your choice of research problem may determine the course of your career, so choose carefully.

Perspective: Ensuring Retention of Women in Physician-Scientist Training, by James M. Pauff and Misty C. Richards, 30 January 2009. More women than men drop out before completing M.D.-Ph.D. programs. Why?

Women M.D.-Ph.D.s: Life in the Trenches, by Karyn Hede, 30 January 2009. Established and early-career physician-scientists say it's time to focus on solutions, not problems, to advance women in academic medicine.

Programs Aim to Train Translational Scientists, by Brian Vastag, 19 December 2008. New Ph.D. programs in translational medicine provide basic science training and clinical experience.

The Job Outlook for Physician-Scientists, by Karyn Hede, 5 December 2008. Empty training slots and ample job opportunities make the job outlook positive for physician-scientists.

For Physician-Scientists, Conflict-of-Interest Issues Are Complex, by Joel B. Finkelstein, 14 November 2008. Working in the clinic and at the bench means physician-scientists need to be particularly aware of conflicts of interest -- and the appearance of them.

Research in Translation: Getting Published, by Siri Carpenter, 29 February 2008. Planning studies carefully and choosing the right journal are among the keys to publishing your translational research in a top-tier journal.

Special Feature: Translational Research Careers, by Kate Travis, 17 August 2007. Translational research is pushing a fundamental change in the way science operates while giving rise to a new type of researcher: the translational scientist.

Carving a Career in Translational Research, by Siri Carpenter, 17 August 2007. An influx of public and private funding is invigorating a field that challenges some traditional notions of science.

European Programs Offer Translational Training, by Elisabeth Pain, 17 August 2007. In Europe, translational research is fast becoming a priority; new programs are taking a range of approaches to training in this field.

Translational Institute Unites Unlikely Partners at Penn, by Ken Garber, 17 August 2007. Translational research breaks barriers between the lab and the clinic and, at one institute, brings together some unlikely collaborators.

MD-PhD Careers, Feature Index, 3 October 2003.

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