The hemagglutinin protein is bound to the nanoparticle prior to “beheading.”
Between the nanoparticle and specific mutations, the “headless” hemagglutinin construct is stabilized.
A depiction of the nanoparticle vaccine components with (left) and without (right) the variable head region.
The H1N1 stem antibody, shown in light blue, exhibits ability to bind to the H5N1 viral strain.
The H1N1 stem antibody, shown in teal, exhibits ability to bind to the H5N1 viral strain, shown in light blue.

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