Special Issue | 6 June 2013Morphogenesis

Science's Special Issue on Morphogenesis includes reviews on the mechanics of epithelial tissue, self-organizing mini-organs, and advances in imaging morphogenesis.

From Science


Getting into Shape

As development progresses from a single fertilized egg to 2, 4, 8, 16 cells, and so on, the early apparent homogeneity soon transitions to cells displaying varied sizes and shapes...

Imaging Morphogenesis: Technological Advances and Biological Insights

Emerging imaging techniques record morphogenesis at temporal and spatial scales to enable biological insights.

Third-harmonic generation (THG) imaging of the early zebrafish embryo. Scale bar: 100 μm. [Credit: Olivier et al. 2008]


Mechanics of Epithelial Tissue Homeostasis and Morphogenesis

This review details the mechanical basis of cell division, extrusion, and intercalation during epithelial morphogenesis.

Live imaging of Endocad::GFP (red) and MyoII::mCherry (green) in embryos at stage 10 showing epithelial cell division.


Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

The development and possible applications of intestinal organoids as grown from single stem cells.

Histone H2B-GFP organoids followed by real-time imaging. Courtesy of Inke Nathke, University of Dundee.


See Also:

  • Science Careers
    Philipp Keller is singularly focused on improving quantitative microscopy techniques, no matter where that takes him.
  • Special Section
    Mysteries of Development

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