From Science


Defeating the Dementors


Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Depression causes neuronal atrophy and decreased synaptic connections in brain areas that control emotion, mood, and cognition.


Depression and Hippocampal Neurogenesis: A Road to Remission?

Adult hippocampal neurogenesis as a possible target for the treatment of depression.

Are We Getting Closer to Valid Translational Models for Major Depression?

Developing appropriate animal models of depression continues to be a substantial challenge.


The Science of Resilience: Implications for the Prevention and Treatment of Depression

Finding the reasons why some individuals are more protected against depression than others might improve future therapies.
Related Review in Science

Theory and Simulation in Neuroscience

A review of the interaction of theory and simulation using examples of top-down and bottom-up studies and some current developments in the fields of computational and theoretical neuroscience.
Related Editorial in Science

The Burden of Mood Disorders

Reducing the burdens of mood disorders requires major shifts in research, clinical practice, and public health by incorporating multidisciplinary models of intervention.

From Science Signaling

Science Signaling Perspective

HCN1 Channels: A New Therapeutic Target for Depressive Disorders?

Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels may relieve depression.
Science Signaling Perspective

Inflammatory Factors Contribute to Depression and Its Comorbid Conditions

Manipulation of pro- and anti-inflammatory mediators may improve treatments for depression.

From Science Translational Medicine

Science Translational Medicine Perspective

Next Generation Treatments for Mental Disorders

New approaches are needed for developing next generation treatments for mental disorders.
Science Translational Medicine Commentary

Revolution Stalled

Drug discovery for psychiatric disorders is at a near standstill.
Also in this Issue
Related News Focus: Mysteries of the Brain