Special Issue | 28 March 2014Breast Cancer

INTRODUCTIONScience's special section on breast cancer takes a look at the state of research and treatment 20 years after the isolation of the BRCA1 gene. [Read the full introduction]


From Science

Perspective

"The Race" to Clone BRCA1

A pioneer in breast cancer genetics reflects on the long and tortuous path leading to the discovery of the BRCA1 gene.
Perspective

Two Decades after BRCA: Setting Paradigms in Personalized Cancer Care and Prevention"

Screening for BRCA mutations in high-risk families has improved patient care, but the test results sometimes pose challenges.
Perspective

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

The BRCA proteins preserve the structural and numerical integrity of chromosomes, which may explain their tumor suppressor role.
Editorial

Breast Cancer—Thinking Globally

An unacceptable number of women with breast cancer in low- and middle-income countries have no access to effective treatment.
 
News Graphic

Breast Cancer: A World of Differences

Advances in detecting and treating breast cancer offer an ever brightening outlook for women diagnosed in wealthy countries, but the recent progress has been far from uniform, and in poor countries mortality remains disproportionately high.
News

Dare to Do Less

Scientists are looking for ways to spare women from aggressive treatment of ductal carcinoma in situ, a diagnosis that only sometimes leads to invasive breast cancer.
News

The 'Other' Breast Cancer Genes

Since the discovery of BRCA1 and BRCA2, dozens more breast cancer genes have come to light. But what risk they pose—and what to tell women who carry them—remain quandaries.
News

The Advocate

For more than 2 decades, Fran Visco, president of the National Breast Cancer Coalition, has been a force behind the second biggest U.S. breast cancer research program.

From Science Signaling

Science Signaling Perspective

Flipping the Switch: Integrin-Switching Provides Metastatic Competence

Cancer growth and metastasis is delicately regulated by distinct β integrins.
Science Signaling Perspective

MicroRNA Circuits Regulate the Cancer-Inflammation Link

Increased inflammatory signaling in breast cancer is explained by the loss of a negative feedback loop.
 
Science Signaling Research Article

Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple Negative Breast Cancer

Predictions regarding drug resistance mechanisms and treatment strategies in triple negative breast cancer are confirmed in tumors from patients.

From Science Translational Medicine

Science Translational Medicine Research Article

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

The cancer drug paclitaxel causes tumor regression and cell death by inducing chromosome missegregation on multipolar spindles.
 
Science Translational Medicine Research Article

Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer

Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors.
 

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