Nobel Laureates Published in Science

Science has published articles by Nobel Laureates since the award's inception in 1901!
Award categories include Chemistry, Physics, and Medicine.

Download a printable version with the most recent Nobel Prize recipients.

Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Shuji Nakamura 2014 Physics US The Roles of Structural Imperfections in InGaN-Based Blue Light-Emitting Diodes and Laser Diodes Science 14 August 1998
   
Eric Betzig 2014 Chemistry US Lattice Light-Sheet Microscopy: Imaging Molecules to Embryos at High Spatiotemporal Resolution Science 24 October 2014
        A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro Science 22 March 2013
        Triggering A Cell Shape Change by Exploiting Pre-Existing Actomyosin Contractions Science 9 March 2012
        Imaging Intracellular Fluorescent Proteins at Nanometer Resolution Science 15 September 2006
        Nanoscale Complexity of Phospholipid Monolayers Investigated by Near-Field Scanning Optical Microscopy Science Classic 27 October 1995
        Near-Field Spectroscopy of the Quantum Constituents of a Luminescent System Science Classic 17 June 1994
        Single Molecules Observed by Near-Field Scanning Optical Microscopy Science Classic 26 November 1993
        Near-Field Optics: Microscopy, Spectroscopy, and Surface Modification Beyond the Diffraction Limit Science Classic 10 July 1992
        Breaking the Diffraction Barrier: Optical Microscopy on a Nanometric Scale Science Classic 22 March 1991
Stefan W. Hell 2014 Chemistry Germany Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescent Nanoscopy Science 26 October 2012
        RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release Science 16 December 2011
        Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement Science 11 April 2008
        Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster Science 24 August 2007
        Far-Field Optical Nanoscopy Science 25 May 2007
        Bruchpilot Promotes Active Zone Assembly, Ca2+ Channel Clustering, and Vesicle Release Science 13 April 2006
William E. Moerner 2014 Chemistry US Illuminating Single Molecules in Condensed Matter Science 12 March 1999
        Those Blinking Single Molecules Science 22 August 1997
        Spontaneous Oscillation and Self-Pumped Phase Conjugation in a Photorefractive Polymer Optical Amplifier Science 25 July 1997
        Three-Dimensional Imaging of Single Molecules Solvated in Pores of poly(acrylamide) Gels Science Classic 8 November 1996
        Examining Nanoenvironments in Solids on the Scale of a Single, Isolated Impurity Molecule Science Classic 1 July 1994
John O' Keefe 2014 Physiology or Medicine UK Neural Representations of Location Composed of Spatially Periodic Bands Science 17 August 2012
        Development of Hippocampal Cognitive Map in Preweanling Rats Science 18 June 2010
        Attractor Dynamics in the Hippocampal Representation of the Local Environment Science 6 May 2005
May-Britt Moser 2014 Physiology or Medicine Norway Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity Science 5 April 2013
        Development of the Spatial Representation System in the Rat Science 18 June 2010
        Representation of Geometric Borders in the Entorhinal Cortex Science 19 December 2008
        Finite Scale of Spatial Representation in the Hippocampus Science 4 July 2008
        Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus Science 16 February 2007
        Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex Science 5 May 2006
        Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles Science 22 July 2005
        Spatial Representation in the Entorhinal Cortex Science 27 August 2004
        Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1 Science 22 July 2004
        Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry Science 21 June 2002
        Impaired Spatial Learning after Saturation of Long-Term Potentiation Science 25 September 1998
Edvard I. Moser 2014 Physiology or Medicine Norway Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity Science 5 April 2013
        Development of the Spatial Representation System in the Rat Science 18 June 2010
        Representation of Geometric Borders in the Entorhinal Cortex Science 19 December 2008
        Finite Scale of Spatial Representation in the Hippocampus Science 4 July 2008
        Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus Science 16 February 2007
        Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex Science 5 May 2006
        Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles Science 22 July 2005
        Spatial Representation in the Entorhinal Cortex Science 27 August 2004
        Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1 Science 22 July 2004
        Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry Science 21 June 2002
        Impaired Spatial Learning after Saturation of Long-Term Potentiation Science 25 September 1998
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Martin Karplus 2013 Chemistry Austria How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations Science 9 January 2004
        "New View" of Protein Folding Reconciled with the Old Through Multiple Unfolding Simulations Science 12 December 1997
        Solution of a Protein Crystal Structure with a Model Obtained from NMR Interproton Distance Restraints Science February 1987
        Crystallographic R Factor Refinement by Molecular Dynamics Science 23 January 1987
Michael Levitt 2013 Chemistry UK Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex Science 26 September 2013
        Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution Science 29 May 2009
Arieh Warshel 2013 Chemistry Israel Dispersed polaron simulations of electron transfer in photosynthetic reaction centers Science 6 October 1989
James E. Rothman 2013 Medicine US Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages Science 14 September 2012
        SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open Science 16 March 2012
        Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity Science 28 October 2011
        Membrane Fusion: Grappling with SNARE and SM Proteins Science 23 January 2009
        Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion Science 23 January 2009
        A Clamping Mechanism Involved in SNARE-Dependent Exocytosis Science 4 August 2006
        Fusion of Cells by Flipped SNAREs Science 13 June 2003
        Regulation of Protein Secretion Through Controlled Aggregation in the Endoplasmic Reticulum Science 4 February 2000
        Throttles and Dampers: Controlling the Engine of Membrane Fusion Science 23 May 1997
        Bimodal Interaction of Coatomer with the p24 Family of Putative Cargo Receptors Science 6 September 1996
Randy W. Schekman 2013 Medicine US Unconventional Secretion, Unconventional Solutions Science 3 May 2013
        George E. Palade (1912-2008) Science 31 October 2008
        Protein Translocation Across Biological Membranes Science 2 December 2005
        BAR Domains Go on a Bender Science 23 January 2004
        Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs Science 31 July 1998
        Coat Proteins and Vesicle Budding Science 15 March 1996
Thomas C. Südhof 2013 Medicine Germany A Neural Circuit for Memory Specificity and Generalization Science 15 March 2013
        α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro Science 24 September 2010
        Membrane Fusion: Grappling with SNARE and SM Proteins Science 23 January 2009
        Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion Science 23 January 2009
        Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion Science 12 September 2008
        A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice Science 5 October 2007
        SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly Science 30 August 2002
        SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice Science 2 November 2001
        A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60 Science 6 July 2001
        Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion Science 4 February 2004
        Postsynaptic Membrane Fusion and Long-Term Potentiation Science 16 January 1998
        Binding of Neuroligins to PSD-95 Science 5 September 1997
        Bipartite Ca2+-Binding Motif in C2 Domains of Synaptotagmin and Protein Kinase C Science 12 July 1996
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Shinya Yamanaka 2012 Medicine Japan Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors Science 7 November 2008
        Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells Science 1 August 2008
        Reactivation of the Paternal X Chromosome in Early Mouse Embryos Science 30 January 2004
Sir John B Gourdon 2012 Medicine UK Nuclear Reprogramming in Cells Science 19 December 2008
David J. Wineland 2012 Physics US Optical Clocks and Relativity Science 24 September 2010
        Complete Methods Set for Scalable Ion Trap Quantum Information Processing Science 4 September 2009
        Frequency Ratio of Al+ and Hg+ Single-Ion Optical Clocks; Metrology at the 17th Decimal Place Science 28 March 2008
        Spectroscopy Using Quantum Logic Science 29 July 2005
        Implementation of the Semiclassical Quantum Fourier Transform in a Scalable System Science 13 May 2005
        Toward Heisenberg-Limited Spectroscopy with Multiparticle Entangled States Science 4 June 2004
        An Optical Clock Based on a Single Trapped 199Hg+ Ion Science 3 August 2001
        A Decoherence-Free Quantum Memory Using Trapped Ions Science 9 February 2001
        Bragg Diffraction from Crystallized Ion Plasmas Science 30 January 1998
        A "Schrödinger Cat" Superposition State of an Atom Science 24 May 1996
        Laser Spectroscopy of Trapped Atomic Ions Science 7 August 1987
        Trapped Ions, Laser Cooling, and Better Clocks Science 26 October 1984
Serge Haroche 2012 Physics Morocco Step-by-Step Engineered Multiparticle Entanglement Science 16 June 2000
Brian K. Kobilka 2012 Chemistry US GPCR Engineering Yields High-Resolution Structural Insights into β2-Adrenergic Receptor Function Science 23 November 2007
        High-Resolution Crystal Structure of an Engineered Human β2-Adrenergic G Protein–Coupled Receptor Science 23 November 2007
        Counting Low-Copy Number Proteins in a Single Cell Science 5 January 2007
        βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance Science 2 August 2002
        Cardiovascular Regulation in Mice Lacking α2-Adrenergic Receptor Subtypes b and c Science 9 August 1996
        Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity Science 3 June 1988
        Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Science 30 October 1987
Robert J. Lefkowitz 2012 Chemistry US Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gβγ Science 23 May 2003
        Transduction of Receptor Signals by β-Arrestins Science 22 April 2005
        Dishevelled 2 Recruits β-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4 Science 5 September 2003
        β-Arrestin 2 Mediates Endocytosis of Type III TGF-β Receptor and Down-Regulation of Its Signaling Science 5 September 2003
        Targeting of Cyclic AMP Degradation to β2-Adrenergic Receptors by β-Arrestins Science 25 October 2002
        Molecular Basis for Interactions of G Protein βγ Subunits with Effectors Science 22 May 1998
        Targeting the Receptor-Gq Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy Science 24 April 1998
        Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors Science 25 June 2004
        Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2 Science 24 December 1999
        Regulation of Receptor Fate by Ubiquitination of Activated β2-Adrenergic Receptor and β-Arrestin Science 9 November 2001
        β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3 Science 24 November 2000
        Activity-Dependent Internalization of Smoothened Mediated by β-Arrestin 2 and GRK2 Science 24 December 2004
        β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium Science 27 June 2008
        Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by β-Arrestins Science 2 February 2007
        β-Arrestin-Dependent Formation of β2 Adrenergic Receptor-Src Protein Kinase Complexes Science 29 January 1999
        Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor Science 2 June 1995
        Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor Science 22 April 1994
        Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors Science 5 March 1993
        Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization Science 5 February 1993
        Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors Science 28 August 1992
        Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit Science 5 October 1990
        beta-Arrestin: a protein that regulates beta-adrenergic receptor function Science 22 June 1990
        Beta-adrenergic receptor kinase: primary structure delineates a multigene family Science 13 October 1989
        Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity Science 3 June 1988
        Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor Science 30 October 1987
        Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system Science 24 August 1984
        Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding Science 21 May 1976
        Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma Science 6 November 1970
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Saul Perlmutter
2011
Physics
US
The Cosmic Triangle: Revealing the State of the Universe
Science 28 May 1999
Brian P. Schmidt
2011
Physics
US/Australia
The Link Between Supernovae and Gamma Ray Bursts
Science 27 May 2005
Bruce A. Beutler
2011
Medicine
US
Tuning of Natural Killer Cell Reactivity by NKp46 and Helios Calibrates T Cell Responses
Science 20 January 2012
  Plant and Animal Sensors of Conserved Microbial Signatures
Science 19 November 2010
  Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
Science 31 July 2009
  The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
Originally published in Science Express on 1 May 2008
  Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
Science 22 December 2006
  Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency
Originally published in Science Express on 14 September 2006
  Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Science 11 December 1998
  Unraveling Function in the TNF Ligand and Receptor Familie
Science 29 April 1994
  Shock and tissue injury induced by recombinant human cachectin
Science 24 October 1986
  Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance
Science 23 May 1986
  Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
Science 30 August 1985
  A macrophage factor inhibits adipocyte gene expression: an in vitro model of cachexia
Science 30 August 1985
Jules A. Hoffmann
2011
Medicine
France
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
Science 19 December 2003
  Immunity-Related Genes and Gene Families in Anopheles gambiae
Science 4 October 2002
  Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
Science 5 July 2002
  Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
Science 17 September 1999
  Phylogenetic Perspectives in Innate Immunity
Science 21 May 1999
  A Cytokinin (Isopentenyl-Adenosyl-Mononucleotide) Linked to Ecdysone in Newly Laid Eggs of Locusta migratoria
Science 29 April 1983
Ralph M. Steinman
2011
Medicine
US/Canada
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Science 5 January 2007
  Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
Science 21 April 2000
  Rapid Infection of Oral Mucosal-Associated Lymphoid Tissue with Simian Immunodeficiency Virus
Science 20 August 1999
  Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
Science 16 October 1998
  Replication of HIV-1 in Dendritic Cell-Derived Syncytia at the Mucosal Surface of the Adenoid
Science 5 April 1996
  Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages
Science 14 May 1993
  Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule
Science 8 January 1993
  Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells
Science 17 July 1992
 
Protein-specific helper T-lymphocyte formation initiated by dendritic cells
Science 2 August 1985
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Robert G. Edwards
2010
Medicine
US
Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro
Science 24 February 1984
Andre Geim
2010
Physics
Russia/UK
Graphene: Status and Prospects
Science 19 June 2009
Control of Graphene's Properties by Reversible Hydrogenation: Evidence for Graphane
Science 30 January 2009
Fine Structure Constant Defines Visual Transparency of Graphene
Originally published
in Science Express
on 3 April 2008
Chaotic Dirac Billiard in Graphene Quantum Dots
Science 18 April 2008
Room-Temperature Quantum Hall Effect in Graphene
Originally published
in Science Express
on 15 February 2007
Electric Field Effect in Atomically Thin Carbon Films
Science 22 October 2004
Konstantin Novoselov
2010
Physics
Russia/UK
Control of Graphene's Properties by Reversible Hydrogenation: Evidence for Graphane
Science 30 January 2009
Fine Structure Constant Defines Visual Transparency of Graphene
Originally published
in Science Express
on 3 April 2008
Chaotic Dirac Billiard in Graphene Quantum Dots
Science 18 April 2008
Room-Temperature Quantum Hall Effect in Graphene
Originally published
in Science Express
on 15 February 2007
Electric Field Effect in Atomically Thin Carbon Films
Science 22 October 2004
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Venkatraman
Ramakrishnan
2009
Chemistry
UK
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
Originally published in Science Express on 15 October 2009
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
Originally published in Science Express on 15 October 2009
Structure of the 70S Ribosome Complexed with mRNA and tRNA
Originally published in Science Express on 7 September 2006
MOLECULAR BIOLOGY: A Renewed Focus on Transfer RNA
Science 20 May 2005:
Visualizing tmRNA Entry into a Stalled Ribosome
Science 4 April 2003
Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit
Science 4 May 2001
Crystal Structure of an Initiation Factor Bound to the 30S Ribosomal Subunit
Originally published in Science Express on 4 January 2001
Characterization of an extremely large, ligand-induced conformational change in plasminogen
Science 6 April 1990
A complete mapping of the proteins in the small ribosomal subunit of Escherichia coli
Science 4 December 1987
Distribution of protein and RNA in the 30S ribosomal subunit
Science 28 March 1986
Thomas A. Steitz
2009
Chemistry
US
Structural Insight into Nascent Polypeptide Chain-Mediated Translational Stalling
Originally published in Science Express on 29 October 2009
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome
Science 21 August 2009
The Human SepSecS-tRNASec Complex Reveals the Mechanism of Selenocysteine Formation
Science 17 July 2009
The Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation
Science 24 October 2008
Structure of Hexameric DnaB Helicase and Its Complex with a Domain of DnaG Primase
Science 19 October 2007
Structure of a Synaptic Resolvase Tetramer Covalently Linked to Two Cleaved DNAs
Originally published in Science Express on 30 June 2005
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
Originally published in Science Express on 19 September 2002
The Structural Basis of Ribosome Activity in Peptide Bond Synthesis
Science 11 August 2000
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4  Resolution
Science 11 August 2000
Structure of a Transcribing T7 RNA Polymerase Initiation Complex
Science 17 December 1999
Insights into Editing from an Ile-tRNA Synthetase Structure with tRNAIle and Mupirocin
Science 13 August 1999
Crystal structure of lac repressor core tetramer and its implications for DNA looping
Science 23 June 1995
Structure of DNA polymerase I Klenow fragment bound to duplex DNA
Science 16 April 1993
Structural relationship of bacterial RecA proteins to recombination proteins from bacteriophage T4 and yeast
Science 26 March 1993
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
Science 26 June 1992
Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees
30 August 1991
Fragments of the HIV-1 Tat protein specifically bind TAR RNA
Science 14 September 1990
Structural basis for misaminoacylation by mutant E. coli glutaminyl-tRNA synthetase enzymes
Science 1 December 1989
Structure of E. coli glutaminyl-tRNA synthetase complexed with tRNA(Gln) and ATP at 2.8 A resolution
Science 1 December 1989
Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I
Science 8 April 1988
Synthesis of a site-specific DNA-binding peptide
Science 13 February 1987
Space-filling models of kinase clefts and conformation changes
Science 27 April 1979
Ada E. Yonath
2009
Chemistry
Israel
A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstruction
Science 15 May 1987
Elizabeth H.
Blackburn
2009
Medicine
US
Template Boundary in a Yeast Telomerase Specified by RNA Structure
Science 5 May 2000
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
Science 7 March 1997
Telomerase in yeast
Science 21 July 1995
Telomeres and their synthesis
Science 3 August 1990
Functional evidence for an RNA template in telomerase
Science 2 February 1990
Carol W. Greider
2009
Medicine
US
Functional characterization and developmental regulation of mouse telomerase RNA
Science 1 September 1995
Jack W. Szostak
2009
Medicine
US
A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene
Science 21 September 2006
The Emergence of Competition Between Model Protocells
Science 3 September 2004
Experimental Models of Primitive Cellular Compartments: Encapsulation, Growth, and Division
Science 24 October 2003
Structurally complex and highly active RNA ligases derived from random RNA sequences
Science 21 July 1995
Isolation of new ribozymes from a large pool of random sequences [see comment]
Science 10 September 1993
Selection of a ribozyme that functions as a superior template in a self-copying reaction
Science 18 December 1992
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis
Science 29 March 1991
Stereochemical course of catalysis by the Tetrahymena ribozyme
Science 12 May 1989
An alternative pathway for meiotic chromosome segregation in yeast
Science 7 November 1986
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Osamu Shimomura
2008
Chemistry
US
Cypridina Bioluminescence: Light-Emitting Oxyluciferin-Luciferase Complex
Science 13 June 1969
Chaetopterus Photoprotein: Crystallization and Cofactor Requirements for Bioluminescence
Science 15 March 1968
Microdetermination of Calcium by Aequorin Luminescence
Science 21 June 1963
Luminescence Potency of the Cypridina System
Science 1 December 1961
Martin Chalfie
2008
Chemistry
US
Green fluorescent protein as a marker for gene expression
Science 11 February 1994
Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3
Science 3 September 1993
Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons
Science 24 February 1989
Cell-cell interactions in the guidance of late-developing neurons in Caenorhabditis elegans
Science 5 February 1988
Induction of neuronal branching in Caenorhabditis elegans
Science 1 July 1983
Serotonin and octopamine in the nematode Caenorhabditis elegans
Science 28 May 1982
Roger Y. Tsien
2008
Chemistry
US
Mammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome
Science 8 May 2009
The Fluorescent Toolbox for Assessing Protein Location and Function
Science 14 April 2006
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Science 3 May 2002
Multicolor and Electron Microscopic Imaging of Connexin Trafficking
Science 19 April 2002
Alteration of Stimulus-Specific Guard Cell Calcium Oscillations and Stomatal Closing in Arabidopsis det3 Mutant
Science 29 September 2000
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
Science 30 June 2000
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cell
Science 10 July 1998
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase
as Reporter
Science 2 January 1998
Crystal Structure of the Aequorea victoria Green Fluorescent Protein
Science 6 September 1996
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons
Science 9 April 1993
Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3
Science 4 January 1991
Calcium rises abruptly and briefly throughout the cell at the onset of anaphase
Science 22 August 1986
Is cytosolic ionized calcium regulating neutrophil activation?
Science 30 September 1983
Françoise
Barré-
Sinnoussi
2008
Medicine
Germany
Vaccine Protection of Chimpanzeese Against Challenge with HIV-1-Infected Peripheral Blood Mononuclear Cells
Science 19 June 1992
Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS
Science 26 October 1984
Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS
Science 20 July 1984
Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines
Science 6 July 1984
Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes
Science 6 July 1984
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
Science 20 May 1983
Luc Montagnier
2008
Medicine
France
Apoptosis in AIDS
Science 28 May 1993
Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS
Science 26 October 1984
Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS
Science 20 July 1984
Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines
Science 6 July 1984
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
Science 20 May 1983
Effect of interferon-alpha 1 from E. coli on some cell functions
Science 19 September 1980
Harald zur Hausen
2008
Medicine
France
Viruses in human cancers
Science 22 November 1991
Herpes-Type Virus and Chromosome Marker in Normal Leukocytes after Growth with Irradiated Burkitt Cells
Science 1 September 1967
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Gerhard Ertl
2007
Chemistry
Germany
Oscillatory Thermomechanical Instability of an Ultrathin Catalyst
Science 20 June 2003
Spatiotemporal Addressing of Surface Activity
Science 5 October 2001
Spatiotemporal Self-Organization in a Surface Reaction: From the Atomic to the Mesoscopic Scale
Science 31 August 2001
Controlling Chemical Turbulence by Global Delayed Feedback: Pattern Formation in Catalytic CO Oxidation on Pt(110)
Science 18 May 2001
Turing-Type Patterns on Electrode Surfaces
Originally published in Science Express on 22 February 2001
Electrochemical Micromachining
Science 7 July 2000
SURFACE SCIENCE: Electron Dynamics at Surfaces
Science 26 May 2000
Atomic-Scale Structure and Catalytic Reactivity of the RuO2(110) Surface
Science 25 February 2000
Phonon- Versus Electron-Mediated Desorption and Oxidation of CO on Ru(0001)
Science 13 August 1999
Remote Triggering of Waves in an Electrochemical System
Science 9 April 1999
Atomic and Macroscopic Reaction Rates of a Surface-Catalyzed Reaction
Science 12 December 1997
Chemiluminescence in the Agglomeration of Metal Clusters
Science 22 November 1996
Identification of the "Active Sites" of a Surface-Catalyzed Reaction
Science 20 September 1996
Nonequilibrium Structures in Condensed Systems
Science 14 June 1996
Imaging Pattern Formation in Surface Reactions from Ultrahigh Vacuum up to Atmospheric Pressures
Science 27 October 1995
Two-Dimensional Imaging of Potential Waves in Electrochemical Systems by Surface Plasmon Microscopy
Science 4 August 1995
Effects of Boundaries on Pattern Formation: Catalytic Oxidation of CO on Platinum
Science 1 April 1994
Oscillatory Kinetics and Spatio-Temporal Self-Organization in Reactions at Solid Surfaces
Science 20 December 1991
Mario R. Capecchi
2007
Medicine
US
Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
Science 18 July 2003
Altering the genome by homologous recombination
Science 16 June 1989
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice
Science 3 May 1985
Measurement of suppressor transfer RNA activity
Science 26 August 1983
Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor
Science 23 July 1965
Oliver Smithies
2007
Medicine
US
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
Science 18 January 2002
Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
Science 20 November 1998
Requirement of MIP-1 alpha for an inflammatory response to viral infection
Science 15 September 1995
Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension
Science 3 February 1995
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
Science 21 August 1992
An Animal Model for Cystic Fibrosis Made by Gene Targeting
Science 21 August 1992
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells
Science 8 June 1990
Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing
Science 22 December 1978
Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections
Science 22 December 1978
Charon phages: safer derivatives of bacteriophage lambda for DNA cloning
Science 8 April 1977
Initiation of Protein Synthesis at an Unusual Position in an Immunoglobulin Gene?
Science 14 January 1972
Deletions in Immunoglobulin Polypeptide Chains as Evidence for Breakage and Repair in DNA
Science 7 May 1971
Pathways through Networks of Branched DNA
Science 28 August 1970
Genetic Polymorphism of C'3(β1c-Globuiin) in Human Serum
Science 22 November 1968
Fetal Hemoglobin Variants in Mice
Science 24 May 1968
Antibody Variability: Somatic recombination between the elements of "antibody gene pairs" may explain antibody variability
Science 21 July 1967
Disulfide-Bond Cleavage and Formation in Proteins
Science 17 December 1965
Antibody Induction and Tolerance
Science 9 July 1965
Lactic Dehydrogenase: Genetic Control in Mana
Science 22 November 1963
Genetic Control of Some Human Serum beta-Globulins
Science 4 July 1958
Albert Fert
2007
Physics
France
Role of Metal-Oxide Interface in Determining the Spin Polarization of Magnetic Tunnel Junctions
Science 15 October 1999
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Roger D. Kornberg
2006
Chemistry
US
Structure of an RNA Polymerase II–TFIIB Complex and the Transcription Initiation Mechanism
Originally published in Science Express on 12 November 2009
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
Science 29 May 2009
Structure of a Thiol Monolayer-Protected Gold Nanoparticle at 1.1 Resolution
Science 19 October 2007
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
Science 13 February 2004
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
Science 13 February 2004
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3  Resolution
Originally published in Science Express on19 April 2001
Structural Basis of Transcription: RNA Polymerase II at 2.8 ngstrom Resolution
Originally published in Science Express on19 April 2001
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
Science 28 April 2000
Conserved Structures of Mediator and RNA Polymerase II Holoenzyme
Science 12 February 1999
RNA polymerase II initiation factor interactions and transcription start site selection
Science 11 February 1994
Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinase
Science 4 September 1992
Initiation by yeast RNA polymerase II at the adenoviral major late promoter in vitro
Science 3 November 1989
Three-dimensional structure of cholera toxin penetrating a lipid membrane
Science 11 March 1988
Periodicity of deoxyribonuclease I digestion of chromatin
Science 25 May 1979
Preparation of Native Chromatin and Damage Caused by Shearing
Science 28 March 1975
Chromatin Structure: A Repeating Unit of Histones and DNA
Science 24 May 1974
Chromatin Structure: Oligomers of the Histones
Science 24 May 1974
Andrew Z. Fire
2006
Medicine
US
Chromatin-Associated Periodicity in Genetic Variation Downstream of Transcriptional Start Sites
Originally published in Science Express on11 December 2008
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
Originally published in Science Express on23 November 2006
Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1
Science 10 April 1992
Craig C. Mello
2006
Medicine
US
Genetic Requirements for Inheritance of RNAi in C. elegans
Science 31 March 2000
John C. Mather
2006
Physics
US
HISTORY OF SCIENCE: Science and Sputnik
Science 5 October 2007
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Peter Agre
2003
Chemistry
US
STRUCTURAL BIOLOGY: The Atomic Architecture of a Gas Channel
Science 10 September 2004
Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels
Science 9 September 1994
Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein
Science 17 April 1992
Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP
Science 17 November 1989
Roderick MacKinnon
2003
Chemistry
US
Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 Å Resolution  
        A Gating Charge Transfer Center in Voltage Sensors
Science 2 April 2010
Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution
Science 18 December 2009
Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation
Science 10 November 2006
Principles of Selective Ion Transport in Channels and Pumps
Science 2 December 2005
Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling
Originally published in Science Express on7 July 2005
Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel
Originally published in Science Express on7 July 2005
STRUCTURAL BIOLOGY: Membrane Protein Insertion and Stability
Science 4 March 2005
STRUCTURAL BIOLOGY: Voltage Sensor Meets Lipid Membrane
Science 19 November 2004
Gating the Selectivity Filter in ClC Chloride Channels
Originally published in Science Express on20 March 2003
Structure of the Cytoplasmic β Subunit--T1 Assembly of Voltage-Dependent K+ Channels
Science 7 July 2000
The Cavity and Pore Helices in the KcsA K+ Channel: Electrostatic Stabilization of Monovalent Cations
Science 2 July 1999
Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels
Science 3 April 1998
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity
Science 3 April 1998
Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor
Science 14 April 1995
Two identical noninteracting sites in an ion channel revealed by proton transfer
Science 23 September 1994
Functional stoichiometry of Shaker potassium channel inactivation
Science 29 October 1993
A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels
Science 13 November 1992
Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel
Science 22 February 1991
Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels
Science 12 October 1990
Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor
Science 22 September 1989
Paul C. Lauterbur
2003
Medicine
US
Nuclear magnetic resonance technology for medical studies
Science 19 October 1984
Positron Tomography and Nuclear Magnetic Resonance Imaging
Science 5 February 1982
Sir Peter Mansfield
2003
Medicine
UK
Echo-planar imaging: magnetic resonance imaging in a fraction of a second
Science 4 October 1991
Anthony J. Leggett
2003
Physics
UK & US
Quantum Liquids
Science 29 February 2008
PHYSICS: Superfluidity in a Crystal?
Originally published in Science Express on2 September 2004
PHYSICS: Superconducting Qubits--a Major Roadblock Dissolved?
Science 3 May 2002
PHYSICS: Superconductivity Compatibility
Science 20 February 1998
Interlayer Tunneling Models of Cuprate Superconductivity: Implications of a Recent Experiment
Science 25 October 1996
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
John B. Fenn
2002
Chemistry
US
Electrospray ionization for mass spectrometry of large biomolecules
Science 6 October 1989
Molecular Beams with Energies above One Electron Volt
Science 24 February 1967
Kurt Wuthrich
2002
Chemistry
Switzerland
NMR determination of residual structure in a urea-denatured protein, the 434-repressor
Science 11 September 1992
Protein hydration in aqueous solution
Science 15 November 1991
Receptor-induced conformation change of the immunosuppressant cyclosporin A
Science 15 November 1991
Protein structure determination in solution by nuclear magnetic resonance spectroscopy
Science 6 January 1989
The Absence of " Heme-Heme " Interactions in Hemoglobin
Science 18 July 1969
Sydney Brenner
2002
Medicine
UK
Ancient Noncoding Elements Conserved in the Human Genome
Science 22 December 2006
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Originally published in Science Express on25 July 2002
GENOMICS: The End of the Beginning
Science 24 March 2000
Laser microsurgery in cell and developmental biology
Science 31 July 1981
Asilomar conference on recombinant DNA molecules
Science 6 June 1975
H. Robert Horvitz
2002
Medicine
US
Ligand-Gated Chloride Channels Are Receptors for Biogenic Amines in C. elegans
Science 3 July 2009
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
Science 27 February 2009
MicroRNA Expression in Zebrafish Embryonic Development
Originally published in Science Express on26 May 2005
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
Science 25 February 2000
Control of larval development by chemosensory neurons in Caenorhabditis elegans
Science 8 March 1991
Heterochronic mutants of the nematode Caenorhabditis elegans
Science 26 October 1984
Serotonin and octopamine in the nematode Caenorhabditis elegans
Science 28 May 1982
John E. Sulston
2002
Medicine
UK
Induction of neuronal branching in Caenorhabditis elegans
Science 1 July 1983
Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans
Science 17 June 1983
Serotonin and octopamine in the nematode Caenorhabditis elegans
Science 28 May 1982
Partial Resolution of DL-Adenosine by Template Synthesis
Science 15 November 1968
Template-Directed Synthesis with Adenosine-5'-phosphorimidazolide
Science 26 July 1968
Raymond Davis, Jr.
2002
Physics
US
Solar Neutrinos: A Scientific Puzzle
Science 23 January 1976
Cosmic Ray Production of Rare Gas Radioactivities and Tritium in Lunar Material
Science 30 January 1970
Solar Eruption of May 10, 1949
Science 12 August 1949
Riccardo Giacconi
2002
Physics
US
The Einstein Observatory: New Perspectives in Astronomy
Science 22 August 1980
X-ray Structure of the Cygnus Loop
Science 23 April 1971
X-ray Structures of the Sun during the Importance 1N Flare of 8 June 1968
Science 9 August 1968
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Ryoji Noyori
2001
Chemistry
Japan
A "Green" Route to Adipic Acid: Direct Oxidation of Cyclohexenes with 30 Percent Hydrogen Peroxide
Science 11 September 1998
Homogeneous Catalysis in Supercritical Fluids
Science 25 August 1995
Organic synthesis of prostaglandins: advancing biology
Science 1 January 1993
Organic Synthesis: Current Status in Japan
Science 23 October 1992
Chiral Metal Complexes as Discriminating Molecular Catalysts
Science 8 June 1990
K. Barry Sharpless
2001
Chemistry
US
A Sulfilimine Bond Identified in Collagen IV
Science 4 September 2009
Selective perhydroxylation of squalene: taming the arithmetic demon
Science 1 January 1993
Total Synthesis of the L-Hexoses
Science 27 May 1983
Leland H. Hartwell
2001
Medicine
US
GENETICS: Robust Interactions
Science 6 February 2004
Principles for the Buffering of Genetic Variation
Science 9 February 2001
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
Science 7 November 1997
Cell cycle control and cancer
Science 16 December 1994
Checkpoints: controls that ensure the order of cell cycle events
Science 3 November 1989
The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
Science 15 July 1988
The structure of sister minichromosome DNA before anaphase in Saccharomyces cerevisiae
Science 18 December 1987
Genetic Control of the Cell Division Cycle in Yeast: A model to account for the order of cell cycle events is deduced from the phenotypes of yeast mutants
Science 11 January 1974
Tim Hunt
2001
Medicine
UK
Unmasking the S-Phase-Promoting Potential of Cyclin B1
Science 9 May 2003
Sir Paul M. Nurse
2001
Medicine
UK
The Kinesin Klp2 Mediates Polarization of Interphase Microtubules in Fission Yeast
Science 8 July 2005
Equatorial Retention of the Contractile Actin Ring by Microtubules During Cytokinesis
Science 6 June 2003
CELL CYCLE: License Withheld--Geminin Blocks DNA Replication
Science 22 December 2000
Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase
Science 14 December 1990
Eric A. Cornell
2001
Physics
US
Observation of Bose-Einstein Condensation in a Dilute Atomic Vapor
Science 14 July 1995
Wolfgang Ketterle
2001
Physics
US & Germany
Itinerant Ferromagnetism in a Fermi Gas of Ultracold Atoms
Science 18 September 2009
Pairing Without Superfluidity: The Ground State of an Imbalanced Fermi Mixture
Science 11 May 2007
Imaging the Mott Insulator Shells by Using Atomic Clock Shifts
Science 4 August 2006
Fermionic Superfluidity with Imbalanced Spin Populations
Originally published in Science Express on22 December 2005
Light Scattering to Determine the Relative Phase of Two Bose-Einstein Condensates
Science 25 March 2005
Cooling Bose-Einstein Condensates Below 500 Picokelvin
Science 12 September 2003
Radio-Frequency Spectroscopy of Ultracold Fermions
Originally published in Science Express on8 May 2003
The Onset of Matter-Wave Amplification in a Superradiant Bose-Einstein Condensate
Originally published in Science Express on27 March 2003
A Continuous Source of Bose-Einstein Condensed Atoms
Originally published in Science Express on16 May 2002
Observation of Vortex Lattices in Bose-Einstein Condensates
Originally published in Science Express on22 March 2001
Superradiant Rayleigh Scattering from a Bose-Einstein Condensate
Science 23 July 1999
Bosonic Stimulation in the Formation of a Bose-Einstein Condensate
Science 13 February 1998
Observation of Interference Between Two Bose Condensates
Science 31 January 1997
Direct, Nondestructive Observation of a Bose Condensate
Science 5 July 1996
Carl E. Wieman
2001
Physics
US
Why Peer Discussion Improves Student Performance on In-Class Concept Questions
Science 2 January 2009
Measurement of Parity Nonconservation and an Anapole Moment in Cesium
Science 21 March 1997
Observation of Bose-Einstein Condensation in a Dilute Atomic Vapor
Science 14 July 1995
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Alan J. Heeger
2000
Chemistry
US
High-Detectivity Polymer Photodetectors with Spectral Response from 300 nm to 1450 nm
Originally published in Science Express on13 August 2009
Efficient Tandem Polymer Solar Cells Fabricated by All-Solution Processing
Science 13 July 2007
Templating Organic Semi-conductors via Self-Assembly of Polymer Colloids
Science 21 March 2003
Semiconducting Polymers: A New Class of Solid-State Laser Materials
Science 27 September 1996
Polymer Photovoltaic Cells: Enhanced Efficiencies via a Network of Internal Donor-Acceptor Heterojunctions
Science 15 December 1995
Image Enhancement with Polymer Grid Triode Arrays
Science 8 December 1995
Polymer Light-Emitting Electrochemical Cells
Science 25 August 1995
A 160-Femtosecond Optical Image Processor Based on a Conjugated Polymer
Science 26 August 1994
Photoinduced Electron Transfer from a Conducting Polymer to Buckminsterfullerene
Science 27 November 1992
Alan G. MacDiarmid
2000
Chemistry
US & NZ
Fuel-Powered Artificial Muscles
Science 17 March 2006
Hideki Shirakawa
2000
Chemistry
Japan
Helical Polyacetylene Synthesized with a Chiral Nematic Reaction Field
Science 27 November 1998
Arvid Carlsson
2000
Medicine
Sweden
A Paradigm Shift in Brain Research
Science 2 November 2001
Brain Tryptophan Hydroxylation: Dependence on Arterial Oxygen Tension
Science 5 October 1973
On the Presence of 3-Hydroxytyramine in Brain
Science 28 February 1958
Paul Greengard
2000
Medicine
US
Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
Science 8 January 2010
Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling
Science 11 December 2009
Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity
Science 8 August 2008
Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States
Science 6 January 2006
A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling
Science 22 October 2004
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
Science 25 June 2004
Diverse Psychotomimetics Act Through a Common Signaling Pathway
Science 21 November 2003
The Neurobiology of Slow Synaptic Transmission
Science 2 November 2001
Requirement for DARPP-32 in Progesterone-Facilitated Sexual Receptivity in Female Rats and Mice
Science 11 February 2000
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Science 7 August 1998
Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons
Science 13 May 1994
Synaptic vesicle phosphoproteins and regulation of synaptic function
Science 5 February 1993
Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin
Science 31 July 1992
Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons
Science 6 September 1991
Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia
Science 16 June 1989
A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions
Science 20 November 1987
Synapsin I in nerve terminals: selective association with small synaptic vesicles
Science 7 December 1984
Neuronal phosphoproteins: physiological and clinical implications
Science 21 September 1984
A Diurnal Rhythm in Pineal Protein 1 Content Mediated by β-Adrenergic Neurotransmission
Science 23 July 1982
Corticosterone increases the amount of protein 1, a neuron-specific phosphoprotein, in rat hippocampus
Science 5 June 1981
Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein
Science 4 January 1980
Phosphorylated proteins as physiological effectors
Science 13 January 1978
Neurotransmitters increase cyclic nucleotides in postganglionic neurons: immunocytochemical demonstration
Science 10 October 1975
Adenosine 3',5'-Monophosphate Content in Rat Caudate Nucleus: Demonstration of Dopaminergic and Adrenergic and Receptors
Science 20 December 1974
Guanosine 3',5'-Monophosphate in Sympathetic Ganglia: Increase Associated with Synaptic Transmission
Science 6 December 1974
Octopamine-Sensitive Adenylate Cyclase: Evidence for a Biological Role of Octopamine in Nervous Tissue
Science 20 April 1973
Adenosine 3',5'-Monophosphate: Electrophysiological Evidence for a Role in Synaptic Transmission
Science 20 October 1972
Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission
Science 24 December 1971
Cyclic 3',5'-Nucleotide Phosphodiesterase: Cytochemical Localization in Cerebral Cortex
Science 20 August 1971
Adenosine 3',5'-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission
Science 19 March 1971
Hormone-Sensitive Adenyl Cyclase: Cytochemical Localization in Rat Liver
Science 17 April 1970
Adenosine 3',5'-Monophosphate-Dependent Protein Kinase from Brain
Science 4 July 1969
Fetal Death from Nicotinamide-Deficient Diet and Its Prevention by Chlorpromazine and Imipramine
Science 25 September 1964
Eric R. Kandel
2000
Medicine
US
The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses
Science 2 November 2001
Rapid Increase in Clusters of Presynaptic Proteins at Onset of Long-Lasting Potentiation
Originally published in Science Express on18 October 2001
Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade
Science 26 June 1998
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
Science 16 January 1998
Involvement of Pre- and Postsynaptic Mechanisms in Posttetanic Potentiation at Aplysia Synapses
Science 14 February 1997
Control of Memory Formation Through Regulated Expression of a CaMKII Transgene
Science 6 December 1996
A VAMP-binding protein from Aplysia required for neurotransmitter release
Science 15 September 1995
Neuropeptides, adenylyl cyclase, and memory storage
Science 12 May 1995
Requirement of a critical period of transcription for induction of a late phase of LTP
Science 19 August 1994
Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS
Science 22 July 1994
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus
Science 25 June 1993
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Science 11 June 1993
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons
Science 9 April 1993
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
Science 18 December 1992
Are adult learning mechanisms also used for development?
Science 9 October 1992
Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia
Science 1 May 1992
Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia
Science 1 May 1992
Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening
Science 10 May 1991
Contributions of two types of calcium channels to synaptic transmission and plasticity
Science 23 November 1990
Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons
Science 17 August 1990
Activity-dependent enhancement of presynaptic inhibition in Aplysia sensory neurons
Science 24 March 1989
cAMP evokes long-term facilitation in Aplysia sensory neurons that requires new protein synthesis
Science 17 June 1988
Long-term facilitation in Aplysia involves increase in transmitter release
Science 15 January 1988
A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia
Science 5 December 1986
In situ hybridization to study the origin and fate of identified neurons
Science 18 November 1983
A cellular mechanism of classical conditioning in Aplysia: activity-dependent amplification of presynaptic facilitation
Science 28 January 1983
Differential classical conditioning of a defensive withdrawal reflex in Aplysia californica
Science 28 January 1983
Molecular biology of learning: modulation of transmitter release
Science 29 October 1982
Emergence of posttetanic potentiation as a distinct phase in the differentiation of an identified synapse in Aplysia
Science 28 August 1981
Epileptogenic agents enhance transmission at an identified weak electrical synapse in Aplysia
Science 24 July 1981
Associative Learning in Aplysia: evidence for conditioned fear in an invertebrate
Science 30 January 1981
Associative learning in Aplysia: cellular correlates supporting a conditioned fear hypothesis
Science 30 January 1981
Sensitization in Aplysia: restoration of transmission in synapses inactivated by long-term habituation
Science 27 July 1979
Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica
Science 22 December 1978
Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP
Science 10 December 1976
Presynaptic facilitation as a mechanism for behavioral sensitization in Aplysia
Science 10 December 1976
Two functional effects of decreased conductance EPSP's: synaptic augmentation and increased electrotonic coupling
Science 9 April 1976
Acquisition and Retention of Long-Term Habituation in Aplysia: Correlation of Behavioral and Cellular Processes
Science 14 December 1973
Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia
Science 7 December 1973
Diphasic Postsynaptic Potential: A Chemical Synapse Capable of Mediating Conjoint Excitation and Inhibition
Science 12 May 1972
Long-Term Habituation of a Defensive Withdrawal Reflex in Aplysia
Science 28 January 1972
Central and Peripheral Control of Gill Movements in Aplysia
Science 17 December 1971
Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia
Science 27 March 1970
Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia
Science 27 March 1970
Habituation and Dishabituation of the GM-Withdrawal Reflex in Aplysia
Science 27 March 1970
Neuronal Controls of a Behavioral Response Mediated by the Abdominal Ganglion of Aplysia
Science 16 May 1969
Synaptic Activation of an Electrogenic Sodium Pump
Science 28 February 1969
A Direct Synaptic Connection Mediating Both Excitation and Inhibition
Science 1 December 1967
Opposite Synaptic Actions Mediated by Different Branches of an Identifiable Interneuron in Aplysia
Science 20 January 1967
Ahmed H. Zewail
2000
Chemistry
US & Egypt
Four-Dimensional Electron Microscopy
Science 9 April 2010
4D Nanoscale Diffraction Observed by Convergent-Beam Ultrafast Electron Microscopy
Science 30 October 2009
Dynamics of Chemical Bonding Mapped by Energy-Resolved 4D Electron Microscopy
Science 10 July 2009
4D Imaging of Transient Structures and Morphologies in Ultrafast Electron Microscopy
Science 21 November 2008
4D Electron Diffraction Reveals Correlated Unidirectional Behavior in Zinc Oxide Nanowires
Science 19 September 2008
4D Visualization of Transitional Structures in Phase Transformations by Electron Diffraction Science 2 November 2007
Nonequilibrium Phase Transitions in Cuprates Observed by Ultrafast Electron Crystallography Science 20 April 2007
Dark Structures in Molecular Radiationless Transitions Determined by Ultrafast Diffraction Originally published in Science Express on 6 January 2005
Electrons in Finite-Sized Water Cavities: Hydration Dynamics Observed in Real Time Originally published in Science Express on 16 September 2004
Ultrafast Electron Crystallography of Interfacial Water Science 2 April 2004
Direct Imaging of Transient Molecular Structures with Ultrafast Diffraction Science 19 January 2001
Femtosecond Activation of Reactions and the Concept of Nonergodic Molecules Science 6 February 1998
The Validity of the "Diradical" Hypothesis: Direct Femtoscond Studies of the Transition-State Structures Science 25 November 1994
Laser Femtochemistry Science 23 December 1988
Femtosecond Clocking of the Chemical Bond Science 2 September 1988
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Robert F. Furchgott 1998 Medicine US Release of Autonomic Mediators in Cardiac Tissue by Suprathreshold Stimulation Science 6 February 1959
        ON THE OCCURRENCE, SITES AND MODES OF ORIGIN AND DESTRUCTION, OF PRINCIPLES AFFECTING THE COMPENSATORY VASCULAR MECHANISMS IN EXPERIMENTAL SHOCK Science 16 November 1945
Louis J. Ignarro 1998 Medicine US Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues Science 9 December 1977
        Hormonal Control of Neutrophil Lysosomal Enzyme Release: Effect of Epinephrine on Adenosine 3',5'-Monophosphate Science 1 March 1974
        Enzyme Release from Polymorphonuclear Leukocyte Lysosomes: Regulation by Autonomic Drugs and Cyclic Nucleotides Science 15 June 1973
Ferid Murad 1998 Medicine US Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides Science 7 February 1992
        Cigarette smoke activates guanylate cyclase and increases guanosine 3',5'-monophosphate in tissues Science 2 December 1977
        Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A Science 3 October 1975
Robert B. Laughlin 1998 Physics US PHYSICS: The Cup of the Hand Science 5 March 2004
        The Relationship Between High-Temperature Superconductivity and the Fractional Quantum Hall Effect Science 28 October 1988
Horst L. Störmer 1998 Physics US & Germany Room-Temperature Quantum Hall Effect in Graphene Originally published in Science Express on 15 February 2007
        The Fractional Quantum Hall Effect Science 22 June 1990
        The Quantized Hall Effect Science 17 June 1983
Daniel C. Tsui 1998 Physics US & China Evidence for Charge-Flux Duality near the Quantum Hall Liquid-to-Insulator Transition Science 25 October 1996
        The Quantized Hall Effect Science 17 June 1983
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Paul D. Boyer 1997 Chemistry US Phosphohistidine Science 20 September 1963
John E. Walker 1997 Chemistry UK Structure of the Rotor of the V-Type Na+-ATPase from Enterococcus hirae Originally published in Science Express on 31 March 2005
        Molecular Architecture of the Rotary Motor in ATP Synthase Science 26 November 1999
Stanley B. Prusiner 1997 Medicine US Synthetic Mammalian Prions Science 30 July 2004
        A Transmembrane Form of the Prion Protein in Neurodegenerative Disease Science 6 February 1998
        Prion Diseases and the BSE Crisis Science 10 October 1997
        Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity Science 20 December 1996
        Structural clues to prion replication Science 22 April 1994
        Molecular biology of prion diseases Science 14 June 1991
        Spontaneous neurodegeneration in transgenic mice with mutant prion protein Science 14 December 1990
        Unusual topogenic sequence directs prion protein biogenesis Science 13 April 1990
        Identification of a protein that purifies with the scrapie prion Science 24 December 1982
        Novel proteinaceous infectious particles cause scrapie Science 9 April 1982
        Reversible chemical modification of the scrapie agent Science 11 December 1981
Steven Chu 1997 Physics US Observation of Polymer Conformation Hysteresis in Extensional Flow Science 12 September 2003
        Correlating Structural Dynamics and Function in Single Ribozyme Molecules Science 24 May 2002
        RNA STRUCTURE: Pulling on Hair(pins) Science 27 April 2001
        A Single-Molecule Study of RNA Catalysis and Folding Science 16 June 2000
        Single-Polymer Dynamics in Steady Shear Flow Science 12 March 1999
        Response of Flexible Polymers to a Sudden Elongational Flow Science 28 August 1998
        Single Polymer Dynamics in an Elongational Flow Science 27 June 1997
        Stretching of a single tethered polymer in a uniform flow Science 7 April 1995
        Relaxation of a single DNA molecule observed by optical microscopy Science 6 May 1994
        Direct observation of tube-like motion of a single polymer chain Science 6 May 1994
        Laser Manipulation of Atoms and Particles Science 23 August 1991
William D. Phillips 1997 Physics US Generating Solitons by Phase Engineering of a Bose-Einstein Condensate Science 7 January 2000
        A Well-Collimated Quasi-Continuous Atom Laser Science 12 March 1999
        Microlithography by using neutral metastable atoms and self-assembled monolayers Science 1 September 1995
        Cooling, Stopping, and Trapping Atoms Science 19 February 1988
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Robert F. Curl Jr. 1996 Chemistry US Probing Chemical Reactions: Evidence for Exploration of an Excited Potential Energy Surface at Thermal Energies Science 10 September 1993
        Probing C60 Science 18 November 1988
Sir Harold W. Kroto 1996 Chemistry UK Space, Stars, C60, and Soot Science 25 November 1988
Richard E. Smalley 1996 Chemistry US Macroscopic, Neat, Single-Walled Carbon Nanotube Fibers Science 3 September 2004
        Optical Signatures of the Aharonov-Bohm Phase in Single-Walled Carbon Nanotubes Science 21 May 2004
        Electronic Structure Control of Single-Walled Carbon Nanotube Functionalization Science 12 September 2003
        Structure-Assigned Optical Spectra of Single-Walled Carbon Nanotubes Originally published in Science Express on 29 November 2002
        Band Gap Fluorescence from Individual Single-Walled Carbon Nanotubes Science 26 July 2002
        Fullerene Pipes Science 22 May 1998
        Nanotube Nanodevice Science 3 October 1997
        Single-Electron Transport in Ropes of Carbon Nanotubes Science 28 March 1997
        Diameter-Selective Raman Scattering from Vibrational Modes in Carbon Nanotubes Science 10 January 1997
        Crystalline Ropes of Metallic Carbon Nanotubes Science 26 July 1996
        Unraveling Nanotubes: Field Emission from an Atomic Wire Science 15 September 1995
        Growth and Sintering of Fullerene Nanotubes Science 18 November 1994
        Fullerenes in the Cretaceous-Tertiary Boundary Layer Science 29 July 1994
        Magnetic Susceptibility of Molecular Carbon: Nanotubes and Fullerite Science 1 July 1994
        Uranium Stabilization of C28: A Tetravalent Fullerene Science 18 September 1992
        Formation of Fullerides and Fullerene-Based Heterostructures Science 9 August 1991
        Order and Disorder in C60 and KxC60 Multilayers: Direct Imaging with Scanning Tunneling Microscopy Science 12 July 1991
        Electronic States of KxC60: Insulating, Metallic, and Superconducting Character Science 7 June 1991
        Ordered Overlayers of C60 on GaAs(110) Studied with Scanning Tunneling Microscopy Science 26 April 1991
        Probing C60 Science 18 November 1988
Peter C. Doherty 1996 Medicine US Defective Lymphoid Development in Mice Lacking Jak3 Science 3 November 1995
Rolf M. Zinkernagel 1996 Medicine Switzerland Recombination of Retrotransposon and Exogenous RNA Virus Results in Nonretroviral cDNA Integration Science 16 January 2009
        Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies Originally published in Science Express on 6 September 2001
        A Primitive T Cell-Independent Mechanism of Intestinal Mucosal IgA Responses to Commensal Bacteria Science 23 June 2000
        Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies Science 10 December 1999
        The Role of Antibody Concentration and Avidity in Antiviral Protection Science 27 June 1997
        Immunology Taught by Viruses Science 12 January 1996
        Functional role of type I and type II interferons in antiviral defense Science 24 June 1994
        The influence of antigen organization on B cell responsiveness Science 26 November 1993
        Immune responses in interleukin-2-deficient mice Science 12 November 1993
        Immune response in mice that lack the interferon-gamma receptor Science 19 March 1993
        Vaccination for disease Science 11 January 1991
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Paul J. Crutzen 1995 Chemistry Netherlands Global Air Pollution Crossroads over the Mediterranean Science 25 October 2002
        Aerosols, Climate, and the Hydrological Cycle Science 7 December 2001
        The Indian Ocean Experiment: Widespread Air Pollution from South and Southeast Asia Science 9 February 2001
        Arctic Ozone Loss Due to Denitrification Science 26 March 1999
        Mass-Independent Oxygen Isotope Fractionation in Atmospheric CO as a Result of the Reaction CO + OH Science 24 July 1998
        ATMOSPHERIC CHEMISTRY: Enhanced: Mesospheric Mysteries Science 26 September 1997
        Atmospheric Aerosols: Biogeochemical Sources and Role in Atmospheric Chemistry Science 16 May 1997
        Observations of Near-Zero Ozone Concentrations Over the Convective Pacific: Effects on Air Chemistry Science 11 October 1996
        A Reevaluation of the Ozone Budget with HALOE UARS Data: No Evidence for the Ozone Deficit Science 5 May 1995
        Role of Deep Cloud Convection in the Ozone Budget of the Troposphere Science 17 June 1994
        Biomass Burning in the Tropics: Impact on Atmospheric Chemistry and Biogeochemical Cycles Science 21 December 1990
        Termites: A Potentially Large Source of Atmospheric Methane, Carbon Dioxide, and Molecular Hydrogen Science 5 November 1982
        Solar Proton Event: Influence on Stratospheric Ozone Science 26 August 1977
        Solar Proton Events: Stratospheric Sources of Nitric Oxide Science 8 August 1975
Mario J. Molina 1995 Chemistry US Atmospheric New Particle Formation Enhanced by Organic Acids Science 4 June 2004
        Physical Chemistry of the H2SO4/HNO3/H2O System: Implications for Polar Stratospheric Clouds Science 10 September 1993
        Antarctic Stratospheric Chemistry of Chlorine Nitrate, Hydrogen Chloride, and Ice: Release of Active Chlorine Science 27 November 1987
F. Sherwood Rowland 1995 Chemistry US Atmospheric Residence Time of CH3Br Estimated from the Junge Spatial Variability Relation Science 17 July 1998
        Urban Leakage of Liquefied Petroleum Gas and Its Impact on Mexico City Air Quality Science 18 August 1995
        Continuing Worldwide Increase in Tropospheric Methane, 1978 to 1987 Science 4 March 1988
        Mercury Concentrations in Museum Specimens of Tuna and Swordfish Science 10 March 1972
        Isotopic Molecules: Separation by Recycle Gas Chromatography Science 14 February 1964
        Production of Radioactive Organic Compounds with Recoil Tritons Science 20 May 1955
Edward B. Lewis 1995 Medicine US Molecular Genetics of the Bithorax Complex in Drosophila melanogaster Science 1 July 1983
        Leukemia, Multiple Myeloma, and Aplastic Anemia in American Radiologists Science 13 December 1963
        Leukemia and Ionizing Radiation Science 17 May 1957
Christiane Nüsslein-Volhard 1995 Medicine Germany Of flies and fishes Science 28 October 1994
        Determination of anteroposterior polarity in Drosophila Science 18 December 1987
Martin L. Perl 1995 Physics US The Scientific Advisory System: Some Observations Science 24 September 1971
Frederick Reines 1995 Physics US The Early Days of Experimental Neutrino Physics Science 5 January 1979
        Neutrinos, Old and New Science 30 August 1963
        Detection of the Free Neutrino: a Confirmation Science 20 July 1956
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
George A. Olah 1994 Chemistry US Stable Carbonium Ions in Solution Science 30 July 1999
Alfred G. Gilman 1994 Medicine US Two-Metal-Ion Catalysis in Adenylyl Cyclase Science 30 July 1999
        Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα13 Science 26 June 1998
        p115 RhoGEF, a GTPase Activating Protein for Gα12 and Gα13 Science 26 June 1998
        Crystal Structure of the Adenylyl Cyclase Activator Gsα Science 12 December 1997
        Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsα•GTPγS Science 12 December 1997
        Tertiary and Quaternary Structural Changes in Giα Induced by GTP Hydrolysis Science 10 November 1995
        Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin Science 23 June 1995
        Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis Science 2 September 1994
        Inhibition of adenylyl cyclase by Gi alpha Science 9 July 1993
        Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits Science 6 December 1991
        Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure Science 30 June 1989
        Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels Science 10 February 1989
        Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase Science 20 September 1985
        Homologies between signal transducing G proteins and ras gene products Science 16 November 1984
        Fluorescent Modification of Adenosine 3',5'-Monophosphate: Spectroscopic Properties and Activity in Enzyme Systems Science 21 July 1972
        Norepinephrine Stimulated Increase of Cyclic AMP Levels in Developing Mouse Brain Cell Cultures Science 15 October 1971
Martin Rodbell 1994 Medicine US Insulin Activity: The Solid Matrix Science 26 October 1973
        Glucagon-Sensitive Adenyl Cylase in Plasma Membrane of Hepatic Parenchymal Cells Science 2 May 1969
        N-Terminal Amino Acid and Lipid Composition of Lipoproteins from Chyle and Plasma Science 28 March 1958
Clifford G. Shull 1994 Physics US X-Ray, Electron, and Neutron Diffraction Science 23 July 1948
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Kary B. Mullis 1993 Chemistry US Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase Science 29 January 1988
        Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia Science 20 December 1985
Michael Smith 1993 Chemistry Canada Oligodeoxyribonucleotides: Chemical Synthesis in Anhydrous Base Science 27 February 1970
Richard J. Roberts 1993 Medicine US The Sequence of the Human Genome Science 16 February 2001
        Steps toward computer analysis of nucleotide sequences Science 19 September 1980
Phillip A. Sharp 1993 Medicine US Divergent Transcription from Active Promoters Originally published in Science Express on 4 December 2008
        Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites Science 20 June 2008
        TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation Science 12 August 2005
        Predictive Identification of Exonic Splicing Enhancers in Human Genes Originally published in Science Express on 11 July 2002
        MOLECULAR BIOLOGY: RNA Interference Science 31 March 2000
        Tat-SF1: Cofactor for Stimulation of Transcriptional Elongation by HIV-1 Tat Science 25 October 1996
        Structure-based design of transcription factors Science 6 January 1995
        Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP Science 23 September 1994
        Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites Science 15 May 1992
        "Five easy pieces" Science 1 November 1991
        Messenger RNA transport and HIV rev regulation Science 10 August 1990
        Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif Science 29 July 1988
        The evolution of catalytic function Science 6 November 1987
        The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter Science 30 October 1987
        Splicing of messenger RNA precursors Science 13 February 1987
        Affinity chromatography of splicing complexes: U2, U5, and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome Science 19 September 1986
        Heterogeneous nuclear ribonucleoproteins: role in RNA splicing Science 28 March 1986
        Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors Science 31 August 1984
        Measurement of suppressor transfer RNA activity Science 26 August 1983
Joseph H. Taylor Jr. 1993 Physics US Millisecond Pulsar PSR 1937+21: A Highly Stable Clock Science 6 November 1987
        How Does the Striate Cortex Begin the Reconstruction of the Visual World? Science 2 July 1971
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Rudolph A. Marcus 1992 Chemistry US Strange and Unconventional Isotope Effects in Ozone Formation Originally published in Science Express on 31 May 2001
        Skiing the Reaction Rate Slopes Science 12 June 1992
Edmond H. Fischer 1992 Medicine US Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes Science 26 July 1991
        Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis Science 19 July 1985
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Erwin Neher 1991 Medicine Germany Distinct Kinetic Changes in Neurotransmitter Release After SNARE Protein Cleavage Science 15 July 2005
        Emerging Roles of Presynaptic Proteins in Ca++-Triggered Exocytosis Science 25 October 2002
        A Ca-dependent early step in the release of catecholamines from adrenal chromaffin cells Science 12 November 1993
        Ion channels for communication between and within cells Science 24 April 1992
        IgG from patients with Lambert-Eaton syndrome blocks voltage-dependent calcium channels Science 22 January 1988
Bert Sakmann 1991 Medicine Germany Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses Science 16 June 2006
        High-Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex Science 12 December 2003
        Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient Mice Science 29 June 2001
        Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal Science 11 August 2000
        Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning Science 11 June 1999
        Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs Science 10 January 1997
        Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites Science 14 April 1995
        Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor Science 4 September 1992
        Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells Science 12 June 1992
        Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes Science 22 May 1992
        Elementary steps in synaptic transmission revealed by currents through single ion channels Science 24 April 1992
        Structural determinants of ion flow through recombinant glutamate receptor channels Science 21 June 1991
        Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS Science 28 September 1990
        A family of AMPA-selective glutamate receptors Science 3 August 1990
Pierre-Gilles de Gennes 1991 Physics France PHYSICS: How Soft Skin Wrinkles Science 18 April 2003
        The Life and Death of "Bare" Viscous Bubbles Science 13 March 1998
        POLYMER PHYSICS: Molecular Individualism Science 27 June 1997
        Soft Matter Science 24 April 1992
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Elias James Corey 1990 Chemistry US Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin Science 5 May 1995
        Antiarthritic gold compounds effectively quench electronically excited singlet oxygen Science 3 April 1987
        Computer-assisted analysis in organic synthesis Science 26 April 1985
        Bronchoconstrictor effects of leukotriene C in humans Science 9 April 1982
        Computer-Assisted Design of Complex Organic Syntheses Science 10 October 1969
Joseph E. Murray 1990 Medicine US Human organ transplantation: background and consequences Science 5 June 1992
        Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor Science 23 March 1984
E. Donnall Thomas 1990 Medicine US Direct evidence for a bone marrow origin of the alveolar macrophage in man Science 4 June 1976
        Hemophilia: Role of Organ Homografts Science 10 January 1969
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Sidney Altman 1989 Chemistry US and Canada Selection of guide sequences that direct efficient cleavage of mRNA by human ribonuclease P Science 4 March 1994
        External guide sequences for an RNA enzyme Science 17 August 1990
        Specific interactions in RNA enzyme-substrate complexes Science 22 December 1989
        Model substrates for an RNA enzyme Science 23 October 1987
        A catalytic RNA and its gene from Salmonella typhimurium Science 24 May 1985
        Catalytic activity of an RNA molecule prepared by transcription in vitro Science 20 January 1984
Thomas R. Cech 1989 Chemistry US Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans Science 11 May 2001
        STRUCTURAL BIOLOGY: Enhanced: The Ribosome Is a Ribozyme Science 11 August 2000
        Two Modes of Survival of Fission Yeast Without Telomerase Science 16 October 1998
        A Preorganized Active Site in the Crystal Structure of the Tetrahymena Ribozyme Science 9 October 1998
        Telomerase Catalytic Subunit Homologs from Fission Yeast and Human Science 15 August 1997
        Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase Science 25 April 1997
        Joining the Two Domains of a Group I Ribozyme to Form the Catalytic Core Science 7 February 1997
        RNA Tertiary Structure Mediation by Adenosine Platforms Science 20 September 1996
        Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing Science 20 September 1996
        Assembly of a Ribonucleoprotein Catalyst by Tertiary Structure Capture Science 19 January 1996
        Telomerase and DNA end replication: no longer a lagging strand problem? Science 15 September 1995
        Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site Science 3 February 1995
        Chromosome end games Science 21 October 1994
        Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme Science 16 September 1994
        Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA Science 3 December 1993
        Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins Science 19 November 1993
        Movement of the guide sequence during RNA catalysis by a group I ribozyme Science 23 April 1993
        Aminoacyl esterase activity of the Tetrahymena ribozyme Science 5 June 1992
        Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme Science 24 April 1992
        Visualizing the higher order folding of a catalytic RNA molecule Science 25 January 1991
        Defining the inside and outside of a catalytic RNA molecule Science 21 July 1989
        Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting Science 12 May 1989
        RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme Science 18 March 1988
        The chemistry of self-splicing RNA and RNA enzymes Science 19 June 1987
        The intervening sequence RNA of Tetrahymena is an enzyme Science 31 January 1986
        Oligomerization of intervening sequence RNA molecules in the absence of proteins Science 13 September 1985
        Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli Science 10 May 1985
        A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA Science 11 May 1984
J. Michael Bishop 1989 Medicine US Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC Science 5 July 2002
        Predisposition to neoplastic transformation caused by gene replacement of H-ras1 Science 4 June 1993
        The molecular genetics of cancer Science 16 January 1987
        Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage Science 8 June 1984
        DNA of Rous Sarcoma Virus: Its Nature and Significance Science 7 January 1972
Harold E. Varmus 1989 Medicine US Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung Originally published in Science Express on 28 August 2008
        The New Era in Cancer Research Science 26 May 2006
        Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity Science 23 April 1999
        A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A Science 14 March 1997
        Efficient incorporation of human CD4 protein into avian leukosis virus particles Science 7 December 1990
        Retroviruses Science 10 June 1988
        Oncogenes and transcriptional control Science 4 December 1987
        Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide Science 12 December 1986
        Biochemical and genetic evidence for the hepatitis B virus replication strategy Science 25 April 1986
        Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting Science 13 December 1985
        Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage Science 8 June 1984
        Form and function of retroviral proviruses Science 21 May 1982
        DNA of Rous Sarcoma Virus: Its Nature and Significance Science 7 January 1972
Norman F. Ramsey 1989 Physics US Experiments with Separated Oscillatory Fields and Hydrogen Masers Science 29 June 1990
Hans G. Dehmelt 1989 Physics US Experiments on the Structure of an Individual Elementary Particle Science 2 February 1990
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Johann Deisenhofer 1988 Chemistry Germany Structure of Tracheal Cytotoxin in Complex with a Heterodimeric Pattern-Recognition Receptor Science 24 March 2006
        Structure of the LDL Receptor Extracellular Domain at Endosomal pH Originally published in Science Express on 29 November 2002
        Nucleotide Control of Interdomain Interactions in the Conformational Reaction Cycle of SecA Science 20 September 2002
        Structural Basis of Gating by the Outer Membrane Transporter FecA Science 1 March 2002
        Structural Mechanism for Statin Inhibition of HMG-CoA Reductase Science 11 May 2001
        Crystal Structure of the Cytochrome bc1 Complex from Bovine Heart Mitochondria Science 4 July 1997
        Crystal structure of DNA photolyase from Escherichia coli Science 30 June 1995
        Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's Science 6 August 1993
        The Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridis Science 29 September 1989
Robert Huber 1988 Chemistry Germany Crystal Structure of a Carbon Monoxide Dehydrogenase Reveals a [Ni-4Fe-5S] Cluster Science 17 August 2001
        Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas Science 17 November 1995
        Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution Science 28 April 1995
        Proteasome from Thermoplasma acidophilum: a threonine protease Science 28 April 1995
        Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer Science 15 July 1994
        Structure-function analysis of the ion channel selectivity filter in human annexin V Science 15 October 1993
        The structure of a complex of recombinant hirudin and human alpha-thrombin Science 20 July 1990
        Structural basis for antigen-antibody recognition Science 15 August 1986
Hartmut Michel 1988 Chemistry Germany The Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridis Science 29 September 1989
Sir James W. Black 1988 Medicine UK Drugs from emasculated hormones: the principle of syntopic antagonism Science 4 August 1989
Gertrude B. Elion 1988 Medicine US The purine path to chemotherapy Science 7 April 1989
George H. Hitchings 1988 Medicine US A Mammalian Thioglycosidase Science 21 August 1959
        THE EFFECTS OF PYRIMIDINES ON THE GROWTH OF LACTOBACILLUS CASEI Science 7 September 1945
Leon M. Lederman 1988 Physics US Observations in Particle Physics from Two Neutrinos to the Standard Model Science 12 May 1989
        The 1984 Nobel Prize in Physics Science 11 January 1985
Melvin Schwartz 1988 Physics US The First High-Energy Neurtrino Experiment Science 17 March 1989
Jack Steinberger 1988 Physics Switzerland What Do We Learn from Neutrinos? Science 26 March 1993
        Experiments with High-Energy Neutrino Beams Science 15 September 1989
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Donald J. Cram 1987 Chemistry US The design of molecular hosts, guests, and their complexes Science 6 May 1988
        Cavitands: Organic Hosts with Enforced Cavities Science 11 March 1983
        Host-Guest Chemistry: Complexes between organic compounds simulate the substrate selectivity of enzymes Science 1 March 1974
Jean-Marie Lehn 1987 Chemistry France CHEMISTRY: Dynamic Combinatorial Chemistry Science 23 March 2001
        Supramolecular chemistry Science 18 June 1993
        Supramolecular Chemistry: Receptors, Catalysts, and Carriers Science 22 February 1985
Charles J. Pedersen 1987 Chemistry US The Discovery of Crown Ethers Science 29 July 1988
Susumu Tonegawa 1987 Medicine US Transgenic Inhibition of Synaptic Transmission Reveals Role of CA3 Output in Hippocampal Learning Originally published in Science Express on 24 January 2008
        Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network Originally published in Science Express on 7 June 2007
        Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall Originally published in Science Express on 30 May 2002
        Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCγ Science 10 October 1997
        Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II Science 14 October 1994
        Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice Science 10 July 1992
        Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice Science 10 July 1992
        Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene Science 22 February 1985
        B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo Science 11 January 1985
        Immunoglobulin gene rearrangement in immature B cells Science 19 September 1980
J. Georg Bednorz 1987 Physics Switzerland The Discovery of a Class of High-Temperature Superconductors Science 4 September 1987
        Superconductivity in Alkaline Earth-Substituted La2CuO4-y Science 3 April 1987
K. Alexander Müller 1987 Physics Switzerland The Discovery of a Class of High-Temperature Superconductors Science 4 September 1987
        Superconductivity in Alkaline Earth-Substituted La2CuO4-y Science 3 April 1987
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Yuan T. Lee 1986 Chemistry US UV Absorption Cross Sections of ClOOCl Are Consistent with Ozone Degradation Models Science 8 May 2009
        The Formation of HCS and HCSH Molecules and Their Role in the Collision of Comet Shoemaker-Levy 9 with Jupiter Science 20 February 1998
        A Combined Experimental and Theoretical Study on the Formation of Interstellar C3H Isomers Science 29 November 1996
        Dynamics of Carbonium Ions Solvated by Molecular Hydrogen: CH5+(H2)n (n = 1, 2, 3) Science 7 July 1995
        Molecular Beam Studies of Elementary Chemical Processes Science 15 May 1987
John C. Polanyi 1986 Chemistry Canada Some Concepts in Reaction Dynamics Science 8 May 1987
Stanley Cohen 1986 Medicine US Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei Science 24 September 1993
        The EGF receptor kinase substrate p35 in the floor plate of the embryonic rat CNS Science 17 March 1989
        Epidermal growth factor: identification of a new hormone in human urine Science 5 September 1975
        Estrogenic Induction of Ornithine Decarboxylase in vivo and in vitro Science 16 October 1970
Rita Levi-Montalcini 1986 Medicine Italy The nerve growth factor 35 years later Science 4 September 1987
        Neuronal Properties of Nymphal and Adult Insect Neurosecretory Cells in vitro Science 19 October 1973
        Axonal Outgrowth and Cell Migration in vitro from Nervous System of Cockroach Embryos Science 31 October 1969
        Submaxillary Gland of Mouse: Effects of a Fraction on Tissues of Mesodermal Origin in vitro Science 3 December 1965
        Growth Control of Nerve Cells by a Protein Factor and Its Antiserum Science 10 January 1964
Gerd Binnig 1986 Physics Switzerland True Atomic Resolution by Atomic Force Microscopy Through Repulsive and Attractive Forces Science 4 June 1993
        Smectic Liquid Crystal Monolayers on Graphite Observed by Scanning Tunneling Microscopy Science 7 July 1989
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Herbert A. Hauptman 1985 Chemistry US On the application of the minimal principle to solve unknown structures Science 5 March 1993
        The Direct Methods of X-ray Crystallography Science 11 July 1986
        Valinomycin Crystal Structure Determination by Direct Methods Science 26 May 1972
Jerome Karle 1985 Chemistry US Recovering Phase Information from Intensity Data Science 16 May 1986
        Crystalline Ordering in Silica and Germania Glasses Science 12 January 1973
Michael S. Brown 1985 Medicine US BIOMEDICINE: Lowering LDL--Not Only How Low, But How Long? Science 24 March 2006
        Structure of the LDL Receptor Extracellular Domain at Endosomal pH Originally published in Science Express on 29 November 2002
        Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila Science 3 May 2002
        MOLECULAR MEDICINE: The Cholesterol Quartet Science 18 May 2001
        Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells Science 25 June 1993
        Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase Science 15 January 1993
        Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors Science 30 November 1990
        Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice Science 11 March 1988
        Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit Science 6 June 1986
        A receptor-mediated pathway for cholesterol homeostasis Science 4 April 1986
        Cassette of eight exons shared by genes for LDL receptor and EGF precursor Science 17 May 1985
        The LDL receptor gene: a mosaic of exons shared with different proteins Science 17 May 1985
        Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains Science 11 January 1985
        Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages Science 18 February 1983
        Regulation of plasma cholesterol by lipoprotein receptors Science 8 May 1981
        Receptor-mediated control of cholesterol metabolism Science 16 January 1976
        Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man Science 5 July 1974
Joseph L. Goldstein 1985 Medicine US BIOMEDICINE: Lowering LDL--Not Only How Low, But How Long? Science 24 March 2006
        Structure of the LDL Receptor Extracellular Domain at Endosomal pH Originally published in Science Express on 29 November 2002
        Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila Science 3 May 2002
        MOLECULAR MEDICINE: The Cholesterol Quartet Science 18 May 2001
        Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells Science 25 June 1993
        Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase Science 15 January 1993
        Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors Science 30 November 1990
        Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice Science 11 March 1988
        Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit Science 6 June 1986
        A receptor-mediated pathway for cholesterol homeostasis Science 4 April 1986
        Cassette of eight exons shared by genes for LDL receptor and EGF precursor Science 17 May 1985
        The LDL receptor gene: a mosaic of exons shared with different proteins Science 17 May 1985
        Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains Science 11 January 1985
        Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages Science 18 February 1983
        Regulation of plasma cholesterol by lipoprotein receptors Science 8 May 1981
        Receptor-mediated control of cholesterol metabolism Science 16 January 1976
        Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man Science 5 July 1974
        Lesch-Nyhan Syndrome: Rapid Detection of Heterozygotes by Use of Hair Follicles Science 7 May 1971
Klaus von Klitzing 1985 Physics Germany Dispersion of the Excitations of Fractional Quantum Hall States Originally published in Science Express on 30 April 2009
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Robert Bruce Merrifield 1984 Chemistry US Automated Synthesis of Peptides Science 8 October 1965
        Specificity of Peptides: New aspects of the specificity of peptides with vitamin and hormone action are described. Science 1 August 1958
Niels K. Jerne 1984 Medicine Switzerland The generative grammar of the immune system Science 13 September 1985
        Plaque Formation in Agar by Single Antibody-Producing Cells Science 26 April 1963
Georges J.F. Köhler 1984 Medicine Switzerland Derivation and diversification of monoclonal antibodies Science 19 September 1986
César Milstein 1984 Medicine UK Reshaping human antibodies: grafting an antilysozyme activity Science 25 March 1988
        From antibody structure to immunological diversification of immune response Science 14 March 1986
Carlo Rubbia 1984 Physics Switzerland The European Strategy in Particle Physics Science 24 April 1992
Simon van der Meer 1984 Physics Switzerland Stochastic Cooling and the Accumulation of Antiprotons Science 22 November 1985
Nobel Laureate
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Subject
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Science Article(s)
Original Publication Dates
Henry Taube 1983 Chemistry US Use of a dihydrogen osmium complex as a versatile 1H NMR recognition probe Science 10 April 1992
        Electron transfer between metal complexes: retrospective Science 30 November 1984
        Binuclear Ion Containing Nitrogen as a Bridging Group Science 19 January 1968
Barbara McClintock 1983 Medicine US The significance of responses of the genome to challenge Science 16 November 1984
        CHROMOSOME MORPHOLOGY IN ZEA MAYS Science 14 June 1929
        A GENIC DISTURBANCE OF MEIOSIS IN ZEA MAYS Science 2 November 1928
Subramanyan Chandrasekhar 1983 Physics US On Stars, Their Evolution and Their Stability Science 2 November 1984
        Solar Research and Theoretical Astrophysics Science 5 September 1947
        GALACTIC EVIDENCES FOR THE TIME-SCALE OF THE UNIVERSE Science 18 February 1944
William Alfred Fowler 1983 Physics US When Will a Pulsar in Supernova 1987a Be Seen? Science 13 November 1987
        The Quest for the Origin of the Elements Science 23 November 1984
        A Foundation for research Science 2 May 1975
        Nucleosynthesis in the Early Stages of an Expanding Universe Science 29 April 1966
        Relative Contributions of Uranium, Thorium, and Potassium to Heat Production in the Earth Science 31 January 1964
        Nuclear Clues to the Early History of the Solar System: Light nuclei were synthesized before planetary material had entirely separated from hydrogen Science 23 March 1962
        Origin of the Elements in Stars Science 5 October 1956
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Aaron Klug 1982 Chemistry UK STRUCTURAL BIOLOGY AND BIOCHEMISTRY: RETROSPECTIVE: Max Perutz (1914-2002) Science 29 March 2002
        STRUCTURAL BIOLOGY: A Marvellous Machine for Making Messages Science 8 June 2001
        Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme Science 20 December 1996
        Periodicity of deoxyribonuclease I digestion of chromatin Science 25 May 1979
Sune K. Bergström 1982 Medicine Sweden Prostaglandins: Members of a New Hormonal System: These physiologically very potent compounds of ubiquitous occurrence are formed from essential fatty acids Science 28 July 1967
Bengt I. Samuelsson 1982 Medicine Sweden Leukotrienes and lipoxins: structures, biosynthesis, and biological effects Science 4 September 1987
        Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation Science 6 May 1983
        Prostaglandins: Enzymatic Analysis Science 31 January 1969
John R. Vane 1982 Medicine UK BIOMEDICINE: Back to an Aspirin a Day? Science 19 April 2002
Nobel Laureate
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Subject
Country
Science Article(s)
Original Publication Dates
Kenichi Fukui 1981 Chemistry Japan Role of Frontier Orbitals in Chemical Reactions Science 19 November 1982
        Electronic Structure and Nicotine-like Stimulant Activity in Choline Phenyl Ethers Science 8 July 1960
Roald Hoffmann 1981 Chemistry US Theoretical Organometallic Chemistry Science 6 March 1981
        Orbital Symmetry Control of Chemical Reactions Science 6 February 1970
Roger W. Sperry 1981 Medicine US Some effects of disconnecting the cerebral hemispheres Science 24 September 1982
        Lateralized Suppression of Dichotically Presented Digits after Commissural Section in Man Science 12 July 1968
        Cerebral Organization and Behavior: The split brain behaves in many respects like two separate brains, providing new research possibilities Science 2 June 1961
        Visuo-Motor Integration in Split-Brain Cats Science 8 May 1959
David H. Hubel 1981 Medicine US Segregation of form, color, movement, and depth: anatomy, physiology, and perception Science 6 May 1988
        "Attention" Units in the Auditory Cortex Science 8 May 1959
        Tungsten Microelectrode for Recording from Single Units Science 22 March 1957
Nicolaas Bloembergen 1981 Physics US Nonlinear Optics and Spectroscopy Science 4 June 1982
Kai M. Siegbahn 1981 Physics Sweden Electron Spectroscopy for Atoms, Molecules, and Condensed Matter Science 9 July 1982
        Electron Spectroscopy with Monochromatized X-rays Science 21 April 1972
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Paul Berg 1980 Chemistry US RETROSPECTIVE: Arthur Kornberg (1918-2007) Science 7 December 2007
        Dissections and reconstructions of genes and chromosomes Science 17 July 1981
        Expression of a bacterial gene in mammalian cells Science 19 September 1980
        Hybridization in situ of SV40 plaques: detection of recombinant SV40 virus carrying specific sequences of nonviral DNA Science 8 April 1977
        Asilomar conference on recombinant DNA molecules Science 6 June 1975
        Role of Magnesium in Acetyl Coenzyme A Formation by Acetothiokinase Science 3 April 1959
Walter Gilbert 1980 Chemistry US Absence of polymorphism at the ZFY locus on the human Y chromosome Science 26 May 1995
        How big is the universe of exons? Science 7 December 1990
        Localization of an acetylcholine receptor intron to the nuclear membrane Science 12 January 1990
        Genes-in-pieces revisited Science 17 May 1985
        B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo Science 11 January 1985
        DNA sequencing and gene structure Science 18 December 1981
Frederick Sanger 1980 Chemistry UK Determination of nucleotide sequences in DNA Science 11 December 1981
        Chemistry of Insulin: Determination of the structure of insulin opens the way to greater understanding of life processes Science 15 May 1959
Baruj Benacerraf 1980 Medicine US Role of MHC gene products in immune regulation Science 12 June 1981
        Functional specificity of thymus- dependent lymphocytes Science 25 March 1977
        Histocompatibility-Linked Immune Response Genes Science 21 January 1972
        Radioresistance of Cooperative Function of Carrier-Specific Lymphocytes in Antihapten Antibody Responses Science 23 October 1970
        Immune Response in vitro: Independence of "Activated" Lymphoid Cells Science 21 November 1969
        Genetic Control in Guinea Pigs of Immune Response to Conjugates of Haptens and Poly-L-Lysine Science 29 January 1965
Jean Dausset 1980 Medicine France The major histocompatibility complex in man Science 25 September 1981
        Ranks of Donor-Recipient Histocompatibility for Human Transplantation Science 27 February 1970
George D. Snell 1980 Medicine US Studies in histocompatibility Science 10 July 1981
        ANTIGENIC DIFFERENCES BETWEEN THE SPERM OF DIFFERENT INBRED STRAINS OF MICE Science 22 September 1944
        IDENTICAL TWINS IN A MOUSE CROSS Science 25 December 1936
James Watson Cronin 1980 Physics US Correlation of the Highest-Energy Cosmic Rays with Nearby Extragalactic Objects Science 9 November 2007
        CP Symmetry Violation: The Search for Its Origin Science 12 June 1981
Val Logsdon Fitch 1980 Physics US The Discovery of Charge Conjugation—Parity Asymmetry Science 29 May 1981
Nobel Laureate
Year
Subject
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Science Article(s)
Original Publication Dates
Herbert C. Brown 1979 Chemistry US From Little Acorns to Tall Oaks: From Boranes Through Organoboranes Science 31 October 1980
        Hydrogen Bonding as a Factor in the Ionization of Dicarboxylic Acids Science 2 October 1953
Georg Wittig 1979 Chemistry Germany From Diyls to Ylides to My Idyll Science 7 November 1980
Allan M. Cormack 1979 Medicine US Early two-dimensional reconstruction and recent topics stemming from it Science 26 September 1980
Godfrey N. Hounsfield 1979 Medicine UK Computed medical imaging Science 3 October 1980
Sheldon Lee Glashow 1979 Physics US Chemical Signatures for Superheavy Elementary Particles Science 7 August 1981
        Toward a Unified Theory: Threads in a Tapestry Science 19 December 1980
Abdus Salam 1979 Physics UK Gauge Unification of Fundamental Forces Science 14 November 1980
Steven Weinberg 1979 Physics US Origins Science 4 October 1985
        Conceptual Foundations of the Unified Theory of Weak and Electromagnetic Interactions Science 12 December 1980
        Where We Are Now Science 20 April 1973
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Peter D. Mitchell 1978 Chemistry UK Keilin's respiratory chain concept and its chemiosmotic consequences Science 7 December 1979
Werner Arber 1978 Medicine Switzerland Promotion and limitation of genetic exchange Science 27 July 1979
Daniel Nathans 1978 Medicine US Isolation of mutants of an animal virus in bacteria Science 19 September 1980
        Restriction endonucleases, simian virus 40, and the new genetics Science 23 November 1979
Hamilton O. Smith 1978 Medicine US Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast Originally published in Science Express on 20 August 2009
        Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome Originally published in Science Express on 24 January 2008
        Genome Transplantation in Bacteria: Changing One Species to Another Originally published in Science Express on 28 June 2007
        Environmental Genome Shotgun Sequencing of the Sargasso Sea Originally published in Science Express on 4 March 2004
        The Genome Sequence of the Malaria Mosquito Anopheles gambiae Science 4 October 2002
        A Comparison of Whole-Genome Shotgun-Derived Mouse Chromosome 16 and the Human Genome Science 31 May 2002
        Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae Science 20 July 2001
        The Sequence of the Human Genome Science 16 February 2001
        The Genome Sequence of Drosophila melanogaster Science 24 March 2000
        Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58 Science 10 March 2000
        Global Transposon Mutagenesis and a Minimal Mycoplasma Genome Science 10 December 1999
        Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1 Science 19 November 1999
        Chromosome 2 Sequence of the Human Malaria Parasite Plasmodium falciparum Science 6 November 1998
        Complete Genome Sequence of Treponema pallidum, the Syphilis Spirochete Science 17 July 1998
        Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii Science 23 August 1996
        Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome Science 28 July 1995
        Nucleotide sequence specificity of restriction endonucleases Science 3 August 1979
        Sequential Gene Action in the Establishment of Lysogeny Science 18 December 1964
Pyotr Leonidovich Kapitsa 1978 Physics Russia SCIENCE AND WAR Science 17 April 1942
Arno Allan Penzias 1978 Physics US Nuclear Processing and Isotopes in the Galaxy Science 16 May 1980
        The Origin of the Elements Science 10 August 1979
        Microwave Noise from Rainstorms Science 7 August 1970
        Isotropy of Cosmic Background Radiation at 4080 Megahertz Science 26 May 1967
Robert Woodrow Wilson 1978 Physics US The Cosmic Microwave Background Radiation Science 31 August 1979
        Microwave Noise from Rainstorms Science 7 August 1970
        Attenuation on an Earth-Space Path Measured in the Wavelength Range of 8 to 14 Micrometers Science 19 June 1970
        Isotropy of Cosmic Background Radiation at 4080 Megahertz Science 26 May 1967
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Ilya Prigogine 1977 Chemistry Belgium A Two-Fluid Approach to Town Traffic Science 13 April 1979
        Time, Structure, and Fluctuations Science 1 September 1978
        Multilane Vehicular Traffic and Adaptive Human Behavior Science 2 March 1973
Roger Guillemin 1977 Medicine US Monoclonal antibodies to hypothalamic growth hormone-releasing factor with picomoles of antigen Science 26 November 1982
        Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly Science 5 November 1982
        High-molecular-weight immunoreactive beta-endorphin in extracts of human placenta is a fragment of immunoglobulin G Science 11 April 1980
        Partially modified retro-inverso-enkephalinamides: topochemical long-acting analogs in vitro and in vivo Science 15 June 1979
        Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid Science 19 January 1979
        Peptides in the brain: the new endocrinology of the neuron Science 27 October 1978
        beta-Endorphin: endogenous opiate or neuroleptic? Science 28 October 1977
        beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland Science 30 September 1977
        Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness Science 5 November 1976
        Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone Science 5 January 1973
        Synthetic Polypeptide Antagonists of the Hypothalamic Luteinizing Hormone Releasing Factor Science 26 May 1972
Andrew V. Schally 1977 Medicine US Suppression of ovulation in the rat by an orally active antagonist of luteinizing hormone-releasing hormone Science 8 October 1982
        Corticotropin-releasing factor stimulates accumulation of adenosine 3', 5'-monophosphate in rat pituitary corticotrophs Science 28 May 1982
        Depolarization- and ionophore-induced release of octacosa somatostatin from stalk median eminence synaptosomes Science 21 August 1981
        Aspects of hypothalamic regulation of the pituitary gland Science 6 October 1978
        An analog of enkephalin having prolonged opiate-like effects in vivo Science 1 April 1977
        Somatostatin: abundance of immunoreactive hormone in rat stomach and pancreas Science 19 September 1975
        Hypothalamic Regulatory Hormones: At least nine substances from the hypothalamus control the secretion of pituitary hormones Science 26 January 1973
        Ovulation Induced by Synthetic Luteinizing Hormone-Releasing Hormone in the Hamster Science 29 October 1971
        Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating Hormones Science 10 September 1971
        Enterogastrone Inhibits Eating by Fasted Mice Science 14 July 1967
Rosalyn Yalow 1977 Medicine US Cholecystokinin in the brains of obese and nonobese mice Science 5 January 1979
        Radioimmunoassay: a probe for the fine structure of biologic systems Science 16 June 1978
        Molluscan gastrin: concentration and molecular forms Science 14 November 1975
        Parathyroid Hormone in Plasma in Adenomatous Hyperparathyroidism, Uremia, and Bronchogenic Carcinoma Science 18 November 1966
        Iodoinsulin Used To Determine Specific Activity of Iodine-131 Science 8 April 1966
        Hypoglycemia: A Potent Stimulus to Secretion of Growth Hormone Science 31 May 1963
        Antigens in Insulin Determinants of Specificity of Porcine Insulin in Man Science 1 March 1963
        Correction of Sample Absorption of Radioactivity Science 26 February 1960
Philip Warren Anderson 1977 Physics   A Gross-Pitaevskii Treatment for Supersolid Helium Science 1 May 2009
        PHYSICS: Is There Glue in Cuprate Superconductors? Science 22 June 2007
        Thermodynamics of an Incommensurate Quantum Crystal Originally published in Science Express on 3 November 2005
        c-Axis Electrodynamics as Evidence for the Interlayer Theory of High-Temperature Superconductivity Science 20 February 1998
        Interlayer Tunneling Mechanism for High-Tc Superconductivity: Comparison with c Axis Infrared Experiments Science 26 May 1995
        Interlayer Tunneling and Gap Anisotropy in High-Temperature Superconductors Science 16 July 1993
        Experimental Constraints on the Theory of High-Tc Superconductivity Science 12 June 1992
        The Resonating Valence Bond State in La2CuO4 and Superconductivity Science 6 March 1987
        The 1982 Nobel Prize in Physics Science 19 November 1982
        Local Moments and Localized States Science 28 July 1978
        More Is Different Science 4 August 1972
        Superconductivity Science 24 April 1964
Sir Nevill Francis Mott 1977 Physics UK Electrons in Glass Science 8 September 1978
        Metallic and Nonmetallic Behavior in Transition Metal Oxides Science 3 April 1970
John Hasbrouck van Vleck 1977 Physics US Quantum Mechanics: The Key to Understanding Magnetism Science 14 July 1978
        Two Barrier Phenomena Science 18 September 1953
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
William N. Lipscomb 1976 Chemistry US Escherichia coli AspartateTranscarbamylase:The Relation Between Structure and Function Science 5 August 1988
The Boranes and Their Relatives  Science 3 June 1977
Aqueous Central Cavity in Aspartate Transcarbamylase from Escherichia coli Science 16 February 1973
Framework Rearrangement in Boranes and Carboranes Science 22 July 1966
Baruch S. Blumberg 1976 Medicine US Serum Ferritin as a Predictor of Host Response to Hepatitis B Virus Infection Science 22 April 1983
Hepatitis B Virus and Sex Ratio of Offspring Science 25 August 1978
Australia Antigen and the Biology of Hepatitis B  Science 1 July 1977
Australia Antigen: Detection and Transmission in Shellfish  Science 11 January 1974
Autosomal Linkage between the Albumin and Gc Loci in Humans Science 6 October 1967
Albumin Naskapi: A New Variant of Serum Albumin Science 30 September 1966
Light-Scattering Studies on Hyaluronic Acid Science 10 September 1954
D. Carleton Gajdusek 1976 Medicine US Localization of Amyloid Beta Protein Messenger RNA in Brains from Patients with Alzheimer's Disease Science3 July 1987
Beta Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome  Science  13 March 1987
Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease  Science20 February 1987
HTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy  Science11 January 1985
Infection-Specific Particle from the Unconventional Slow Virus Diseases  Science 27 July 1984
Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam  Science 10 September 1982
Autoantibodies against axonal neurofilaments in patients with Kuru and Creutzfeldt-Jakob disease  Science 10 October 1980
Unconventional viruses and the origin and disappearance of kuru  Science 2 September 1977
Experimental Subacute Spongiform Virus Encephalopathies in Primates and Other Laboratory Animals  Science 5 October 1973
Spontaneous Transformation of Human Brain Cells Grown in vitro and Description of Associated Virus Particles  Science 30 June 1972
Virus of the 1918 Influenza Pandemic Era: New Evidence about Its Antigenic Character Science 3 October 1969
Infection as the Etiology of Spongiform Encephalopathy (Creutzfeldt-Jakob Disease) Science 5 September 1969
Transmission of Experimental Kuru to the Spider Monkey (Ateles geoffreyi) Science 8 November 1968
Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee Science 26 July 1968
Transmission and Passage of Experimental ‘Kuru’ to Chimpanzees  Science 13 January 1967
Burton Richter 1976 Physics US Through the Glass Lightly Science 17 March 1995
From the Psi to Charm: The Experiments of 1975 and 1976  Science 17 June 1977
Samuel Chao Chung Ting 1976 Physics US The Discovery of the J Particle: A Personal Recollection  Science 10 June 1977
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
John Warcup Cornforth 1975 Chemistry Australia & UK Asymmetry and enzyme action Science 9 July 1976
        Mechanism of the Dakin and West Reaction Science 3 November 1950
Vladimir Prelog 1975 Chemistry Switzerland Chirality in chemistry Science 2 July 1976
David Baltimore 1975 Medicine US Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance Science 4 June 2010
        Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation Science 16 September 2005
        Chimeric Nucleases Stimulate Gene Targeting in Human Cells Science 2 May 2003
        The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation Science8 November 2002
        Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors Science 1 Febrary 2002
        Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx Science 18 September 1998
        Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis Science 28 August 1998
        An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death Science 1 November 1996
        Involvement of CRAF1, a relative of TRAF, in CD40 signaling Science 10 March 1995
        Engineering poliovirus as a vaccine vector for the expression of diverse antigens Science 2 September 1994
        Identification of a ten-amino acid proline-rich SH3 binding site Science 19 February 1993
        Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho Science 7 August 1992
        Rel-associated pp40: an inhibitor of the rel family of transcription factors Science 13 September 1991
        RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination Science 22 June 1990
        Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome Science 16 February 1990
        The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias Science 20 October 1989
        Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor Science 27 January 1989
        Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif Science 29 July 1988
        Translation in mammalian cells of a gene linked to the poliovirus 5' noncoding region Science 22 July 1988
        Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells Science 11 March 1988
        The CML-specific P210 bcr/abl protein, unlike v-abl, does not transform NIH/3T3 fibroblasts Science31 July 1987
        Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpart Science 24 July 1987
        Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility Science 19 June 1987
        The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene Science 11 July 1986
        Picornaviruses are no longer black boxes Science 27 September 1985
        DNA elements are asymmetrically joined during the site-specific recombination of kappa immunoglobulin genes Science 10 May 1985
        Chromosomal assignment of the endogenous proto-oncogene C-abl Science 24 December 1982
        Cloned poliovirus complementary DNA is infectious in mammalian cells Science 20 November 1981
        Viruses, polymerases, and cancer Science 14 May 1976
        Asilomar conference on recombinant DNA molecules Science 6 June 1975
        Absence of Polymerase Protein in Virions of Alpha-Type Rous Sarcoma Virus Science 29 September 1972
        Isopycnic Separation of Subcellular Components from Poliovirus-Infected and Normal HeLa Cells Science 1 November 1968
        Virus-Specific Double-Stranded RNA in Poliovirs-Infected Cells Science 6 March 1964
Renato Dulbecco 1975 Medicine Italy & UK A turning point in cancer research: sequencing the human genome Science 7 March 1986
        From the molecular biology of oncogenic DNA viruses to cancer Science 30 April 1976
        Cell Transformation by Viruses Science 21 November 1969
        Transformation of Cells in vitro by Viruses Science 15 November 1963
Howard Martin Temin 1975 Medicine US Rate and mechanism of nonhomologous recombination during a single cycle of retroviral replication Science 8 January 1993
        Retroviral recombination and reverse transcription Science 30 November 1990
        Retrovirus vectors: promise and reality Science 24 November 1989
        High-efficiency ligation and recombination of DNA fragments by vertebrate cells Science 6 May 1983
        The DNA provirus hypothesis Science11 June 1976
Aage Niels Bohr 1975 Physics Denmark Rotational Motion in Nuclei Science 16 July 1976
        Concepts of Nuclear Structure Science2 April 1971
Ben Roy Mottleson 1975 Physics US & Denmark Elementary Modes of Excitation in the Nucleus Science 23 July 1976
Leo James Rainwater 1975 Physics US Background for the Spheroidal Nuclear Model Proposal Science 30 July 1976
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Paul J. Flory 1974 Chemistry US Spatial Configuration of Macromolecular Chains Science 27 June 1975
        Role of Crystallization in Polymers and Proteins Science 13 July 1956
Albert Claude 1974 Medicine Belgium The coming of age of the cell Science 8 August 1975
        THE CONSTITUTION OF PROTOPLASM Science 21 May 1943
        PARTICULATE COMPONENTS OF NORMAL AND TUMOR CELLS Science 19 January 1940
        CHEMICAL COMPOSITION OF THE TUMOR-PRODUCING FRACTION OF CHICKEN TUMOR I Science 1 September 1939
        CONCENTRATION AND PURIFICATION OF CHICKEN TUMOR I AGENT Science 20 May 1938
        PREPARATION OF AN ACTIVE AGENT FROM INACTIVE TUMOR EXTRACTS Science 19 March 1937
        A GROUP OF CHEMICALS ACTIVE IN INCREASING TISSUE PERMEABILITY AND ENHANCING CERTAIN INFECTIOUS PROCESSES Science 18 August 1933
        OBSERVATIONS CONCERNING THE CAUSATIVE AGENT OF A CHICKEN TUMOR Science 6 March 1931
Christian de Duve 1974 Medicine UK, US, Belgium Origin of Mitochondria Science 5 October 1973
George E. Palade 1974 Medicine US Intracellular aspects of the process of protein synthesis Science 1 August 1975
Sir Martin Ryle 1974 Physics UK Radio Telescopes of Large Resolving Power Science 13 June 1975
Antony Hewish 1974 Physics UK Pulsars and High Density Physics Science 13 June 1975
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Geoffrey Wilkinson 1973 Chemistry UK The Long Search for Stable Transition Metal Alkyls Science 12 July 1974
        The Preparation and Properties of Tetrakistrichlorophosphine Nickel Science 29 June 1951
Karl von Frisch 1973 Medicine Austria & Germany Decoding the Language of the Bee Science 23 August 1974
Konrad Lorenz 1973 Medicine Austria Analogy as a Source of Knowledge Science 19 July 1974
Nikolaas Tinbergen 1973 Medicine UK & Netherlands Ethology and Stress Diseases Science 5 July 1974
        On War and Peace in Animals and Man Science 28 June 1968
Leo Esaki 1973 Physics US & Japan Long Journey into Tunneling Science 22 March 1974
Ivar Giaever 1973 Physics US & Norway Cell growth on liquid microcarriers Science 25 March 1983
        Electron Tunneling and Superconductivity Science 29 March 1974
Brian David Josephson 1973 Physics UK The Discovery of Tunneling Supercurrents Science 3 May 1974
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Christian B. Anfinsen 1972 Chemistry US Amino terminal sequence of the major component of human lymphoblastoid interferon Science 1 February 1980
        Principles that Govern the Folding of Protein Chains Science 20 July 1973
        Kinetics of Folding of Staphylococcal Nuclease Science 6 February 1970
        Staphylococcal Nuclease: Size and Specificity of the Active Site Science 27 December 1968
        Preparation of Tritiated Proteins by the Wilzbach Method Science 6 September 1957
        Reductive Cleavage of Disulfide Bridges in Ribonuclease Science 12 April 1957
        Kinetic Aspects of Assembly and Degradation of Proteins Science 31 August 1956
        The Role of Heparin in Lipoprotein Metabolism Science 30 May 1952
        IN VITRO GROWTH AND MULTIPLICATION OF THE MALARIA PARASITE, PLASMODIUM KNOWLESI Science 25 May 1945
Stanford Moore 1972 Chemistry US Pancreatic Ribonuclease: Enzymic and Physiological Properties of a Cross-Linked Dimer Science 1 November 1974
        Chemical Structures of Pancreatic Ribonuclease and Deoxyribonuclease Science4 May 1973
William H. Stein 1972 Chemistry US Chemical Structures of Pancreatic Ribonuclease and Deoxyribonuclease Science4 May 1973
Gerald M. Edelman 1972 Medicine US Learning in and from Brain-Based Devices Science 16 November 2007
        Consciousness and Complexity Science 4 December 1998
        Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing Science 15 May 1987
        Sulfation and phosphorylation of the neural cell adhesion molecule, N-CAM Science28 September 1984
        Neuron-glia adhesion is inhibited by antibodies to neural determinants Science 7 October 1983
        Cell adhesion molecules Science 4 February 1983
        Lateral diffusion of surface molecules in animal cells and tissues Science 21 August 1981
        Surface modulation in cell recognition and cell growth Science 16 April 1976
        Antibody Structure and Molecular Immunology Science 25 May 1973
        Amino Acid Incorporation into Rat Brain Proteins during Spreading Cortical Depression Science 24 January 1969
        Polypeptide Chaini of Immunoglobulins from the Smooth Dogfish (Mustelus canis) Science 23 December 1966
Rodney R Porter 1972 Medicine UK Structural Studies of Immunoglobulins Science 18 May 1973
John Bardeen 1972 Physics US Electron-Phonon Interactions and Superconductivity Science 28 September 1973
        Research Leading to Point-Contact Transistor Science 19 July 1957
Leon Neil Cooper 1972 Physics US A physiological basis for a theory of synapse modification Science 3 July 1987
        Microscopic Quantum Interference in the Theory of Superconductivity Science 7 September 1973
Robert John Schrieffer 1972 Physics US Macroscopic Quantum Phenomena from Pairing in Superconductors Science 22 June 1973
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Gerhard Herzberg 1971 Chemistry Canada & Germany Spectroscopic Studies of Molecular Structure Science 14 July 1972
        The Spectroscopic Laboratory Science 5 September 1947
Earl W. Sutherland 1971 Medicine US Studies on the Mechaninism of Hormone Action Science 4 August 1972
Dennis Gabor 1971 Physics UK & Hungary Holography, 1948-1971 Science 28 July 1972
        Holography Science 2 July 1971
Nobel Laureate
Year
Subject
Country
Science Article(s)
Original Publication Dates
Luis F Leloir 1970 Chemistry Argentina & France Two Decades of Research on Biosynthesis of Saccharides Science 25 June 1971
Sir Bernard Katz 1970 Medicine UK & Germany Quantal Mechanism of Neural Transmitter Release Science 9 July 1971
Ulf S. von Euler 1970 Medicine Sweden Adrenergic Neurotransmitter Functions Science 16 July 1971
        Effect of Reserpine on Release of Noradrenaline from Transmitter Granules in Adrenergic Nerves Science 5 August 1960
        Colorimetric Estimation of Noradrenalin in the Presence of Adrenalin Science 25 November 1949
Julius Axelrod 1970 Medicine US Chromosomal locations of human tissue plasminogen activator and urokinase genes Science 8 November 1985
        Beta-adrenergic mechanism of insulin-induced adrenocorticotropin release from the anterior pituitary Science 30 November 1984
        Stress hormones: their interaction and regulation Science 4 May 1984
        Phospholipid methylation and biological signal transmission Science 5 September 1980
        Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes Science15 June 1979
        Catechol estrogens: presence in brain and endocrine tissues Science12 August 1977
        Adrenaline-forming enzyme in brainstem: elevation in genetic and experimental hypertension Science 6 February 1976
        Octopamine: Presence in Single Neurons of Aplysia Suggests Neurotransmitter Function Science 26 July 1974
        The Pineal Gland: A Neurochemical Transducer Science 28 June 1974
        Pineal β-Adrenergic Receptor: Diurnal Variation in Sensitivity Science7 June 1974
        Pineal Gland: 24-Hour Rhythm in Norepinephrine Turnover Science 12 April 1974
        Amphetamine in Human Plasma: A Sensitive and Specific Enzymatic Assay Science 1 February 1974
        Delta-9-Tetrahydrocannabinol: Localization in Body Fat Science26 January 1973
        Psychotomimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro Science 24 March 1972
        Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves Science 24 December 1971
        Serum Dopamine-β-Hydroxylase: Decrease after Chemical Sympathectomy Science 3 September 1971
        Noradrenaline: Fate and Control of Its Biosynthesis Science 13 August 1971
        Delta-9-Tetrahydrocannabinol: Metabolism and Disposition in Long-Term Marihuana Smokers Science 2 July 1971
        Reduced Catechol-O-Methyltransferase Activity in Red Blood Cells of Women with Primary Affective Disorder Science 18 December 1970
        Marihuana: Studies on the Disposition and Metabolism of Delta-9-Tetrahydrocannabinol in Man Science 18 December 1970
        Octopamine: Normal Occurrence in Sympathetic Nerves of Rats Science 25 April 1969
        Adrenal Tyrosine Hydroxylase: Compensatory Increase in Activity after Chemical Sympathectomy Science 31 January 1969
        Enzymatic Synthesis of Melatonin in Avian Pineal Body: Extraretinal Response to Light Science 2 August 1968
        Visual Pathway Mediating Pineal Response to Environmental Light Science 13 January 1967
        Light-Induced Changes in Pineal Hydroxyindole-O-Metthyltransferase: Abolition by Lateral Hypothalamic Lesions Science 18 November 1966
        Adrenaline Synthesis: Control by the Pituitary Gland and Adrenal Glucocorticoids Science 10 December 1965
        Pituitary Gland: Enzymic Formation of Methanol from S-Adenosylmethionine Science 12 November 1965
        Circadian Rhythm in Pineal Serotonin: Effect of Monoamine Oxidase Inhibition and Reserpine Science 30 July 1965
        Melatonin Synthesis in the Pineal Gland: Effect of Light Mediated by the Sympathetic Nervous System Science 20 March 1964
        Melatonin Synthesis in thePineal Gland: Control by Light Science 22 November 1963
        Melatonin, a Pineal Substance: Effect on the Rat Ovary Science 19 July 1963
        Enzymatic Formation of Adrenaline and Other Catechols from Monophenols Science 3 May 1963
        Localizing Tritiated Norepinephrine in Sympathetic Axons by Electron Microscopic Autoradiography Science 19 October 1962
        Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds Science 4 August 1961
        Effect of Psychotropic Drugs on the Uptake of H3-Norepinephrine by Tissues Science 10 February 1961
        Enzymatic O-Methylation of N-Acetylserotonin to Melatonin Science 29 April 1960
        Inhibitor of O-Methylation of Epinephrine and Norepinephrine in vitro and in vivo Science 25 September 1959
        Blood-Brain Barrier for Adrenaline Science 1 May 1959
        O-methylation, the Principal Route of Metabolism of Epinephrine in Man Science 12 September 1958
        Presence, Formation, and Metabolism of Normetanephrine in the Brain Science 4 April 1958
        O-Methylation of Epinephrine and Other Catechols in vitro and in vivo Science 30 August 1957
        Possible Mechanism of Tolerance to Narcotic Drugs Science 10 August 1956
        Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes Science 22 April 1955
Hannes Alfvén 1970 Physics Sweden Spacecraft Propulsion: New Methods Science 14 April 1972
        Apples in a Spacecraft Science 6 August 1971
        Plasma Physics, Space Research, and the Origin of the Solar System Science4 June 1971
        Mission to an Asteroid Science 9 January 1970
        Two Alternatives for the History of the Moon Science 4 July 1969
        Antimatter, Quasi-stellar Objects, and the Evolution of Galaxies Science 23 May 1969
        Origin of the Moon Science 23 April 1965
Louis Néel 1970 Physics Sweden Magnetism and Local Molecular Field Science 3 December 1971

This database delivers a selection, not a complete collection, of Nobel Prize winning authors and their research published in Science. The types of Science articles featured in this database include Research Articles, Reports, Brevia, Reviews, and Perspectives.