Science Functional Genomics
Special Issues

Since the first foray in 1990, Science's genome special issues have played a unique role in the unfolding story of genomic studies -- combining the reporting of landmark genomes such as the worm, the fly, and the human with vital context for understanding the significance of genomic and post-genomic studies on the larger canvas of biomedicine, and with news coverage of the scientific and political dimensions of the genomic quest. From Mycoplasma to mammal, the special issues have charted the progress, and the pitfalls, of what may be the single greatest scientific collaboration of our time.



Cover, Vol. 302, Issue 5645

Oct 24 2003
Vol. 302, No. 5645
"Genomic Medicine"

VIEWPOINT

Genomics and Global Health: Time for a Reappraisal
David J. Weatherall

[Abstract][Full Text]


VIEWPOINTS

Are We There Yet?
Barbara R. Jasny and Leslie Roberts; Science302, 587 (2003)
[Summary]
Genomic Priorities and Public Health
Kathleen Ries Merikangas and Neil Risch; Science302, 599 (2003)
[Abstract][Full Text]
Reverse Vaccinology and Genomics
Rino Rappuoli and Antonello Covacci; Science302, 602 (2003)
[Abstract][Full Text]
Attrition and Translation
Geoffrey Duyk; Science302, 603 (2003)
[Abstract][Full Text]
Molecular Imaging: Looking at Problems, Seeing Solutions
Harvey R. Herschman; Science302, 605 (2003)
[Abstract][Full Text]

NEWS

Preventing Toxicity With a Gene Test
Eliot Marshall; Science302, 588 (2003)
[Summary][Full Text]

First Check My Genome, Doctor
Eliot Marshall; Science302, 589 (2003)
[Summary][Full Text]

The Twists and Turns in BRCA's Path
Jennifer Couzin; Science302, 591 (2003)
[Summary][Full Text]

Choices--and Uncertainties--for Women With BRCA Mutations
Jennifer Couzin; Science302, 592 (2003)
[Summary][Full Text]
Race and Medicine
Constance Holden; Science302, 594 (2003)
[Summary][Full Text]
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Cover, Vol. 300, Issue 5626

Jun 13 2003
Vol. 300, No. 5626
"Tree of Life"

VIEWPOINT

Evolution of the Protein Repertoire
Cyrus Chothia, Julian Gough, Christine Vogel, and Sarah A. Teichmann

[Abstract][Full Text]


VIEWPOINTS

Charting the Evolutionary History of Life
Andrew M. Sugden, Barbara R. Jasny, Elizabeth Culotta, and Elizabeth Pennisi; Science300, 1691 (2003)
[Summary]
Dating the Tree of Life
Michael J. Benton and Francisco J. Ayala; Science300, 1698 (2003)
[Abstract][Full Text]
The Deep Roots of Eukaryotes
S. L. Baldauf; Science300, 1703 (2003)
[Abstract][Full Text]
Phylogenomics: Intersection of Evolution and Genomics
Jonathan A. Eisen and Claire M. Fraser; Science300, 1706 (2003)
[Abstract][Full Text]
Preserving the Tree of Life
Georgina M. Mace, John L. Gittleman, and Andy Purvis; Science300, 1707 (2003)
[Abstract][Full Text]

NEWS

Modernizing the Tree of Life
Elizabeth Pennisi; Science300, 1692 (2003)
[Summary][Full Text]

Drafting a Tree
Elizabeth Pennisi; Science300, 1694 (2003)
[Summary][Full Text]

Plants Find Their Places on the Tree of Life
Elizabeth Pennisi; Science300, 1696 (2003)
[Summary][Full Text]

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Cover, Vol. 300, Issue 5617

Apr 11 2003
Vol. 300, No. 5617
"Building on the DNA Revolution"

VIEWPOINT

The Human Genome Project: Lessons from Large-Scale Biology
Francis S. Collins, Michael Morgan, and Aristides Patrinos

[Abstract][Full Text]


VIEWPOINTS

Building on the DNA Revolution
Barbara R. Jasny and Leslie Roberts; Science300, 277 (2003)
[Summary]
Realizing the Potential of the Genome Revolution: The Genomes to Life Program
Marvin E. Frazier, Gary M. Johnson, David G. Thomassen, Carl E. Oliver, and Aristides Patrinos; Science300, 290 (2003)
[Abstract][Full Text]
From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes
Robert L. Strausberg and Stuart L. Schreiber; Science300, 294 (2003)
[Abstract][Full Text]
Developing a Platform for Genomic Medicine in Mexico
Gerardo Jimenez-Sanchez; Science300, 295 (2003)
[Abstract][Full Text]

NEWS

A Hothouse of Molecular Biology
Elizabeth Pennisi; Science300, 278 (2003)
[Summary][Full Text]

DNA's Cast of Thousands
Elizabeth Pennisi; Science300, 282 (2003)
[Summary][Full Text]

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Cover, Vol. 298, Issue 5591

Oct 4 2002
Vol. 298, No. 5591
"The Mosquito Genome"

REVIEW

The Genome Sequence of the Malaria Mosquito Anopheles gambiae

R. A. Holt et al..

[Abstract][Full Text]

Web Fig. 1: Annotation of the Anopheles gambiae genome sequence

RESEARCH ARTICLES AND REPORTS

Anopheles gambiae: Genome Sequence, Comparative Genomics, and Molecular Biology

Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
E. M. Zdobnov et al.; Science298, 149 (2002)
[Abstract][Full Text]

Immunity-Related Genes and Gene Families in Anopheles gambiae
G. K. Christophides et al.; Science298, 159 (2002)
[Abstract][Full Text]

Neuropeptides and Peptide Hormones in Anopheles gambiae
M. A. Riehle et al.; Science298, 172 (2002)
[Abstract][Full Text]

G Protein-Coupled Receptors in Anopheles gambiae
C. A. Hill et al.; Science298, 176 (2002)
[Abstract][Full Text]

Evolution of Supergene Families Associated with Insecticide Resistance
H. Ranson et al.; 298, 179 (2002)
[Abstract][Full Text]

Inversions and Gene Order Shuffling in Anopheles gambiae and A. funestus
I. V. Sharakhov et al.; Science298, 182 (2002)
[Abstract][Full Text]

G Protein-Coupled Receptors in Anopheles gambiae
C. A. Hill et al.; Science298, 176 (2002)
[Abstract][Full Text]

In Science Express:
A Polytene Chromosome Analysis of the Anopheles gambiae Species Complex
M. Coluzzi et al.; 10.1126/science.1077769 (2002)
[Abstract][PDF]

Plasmodium falciparum: Genetics, Drug Resistance, and Parasite-Mosquito Interactions

Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
A. B. S. Sidhu, D. Verdier-Pinard, D. A. Fidock; Science298, 210 (2002)
[Abstract][Full Text]

Perspective: A Requiem for Chloroquine
I. M. Hastings, P. G. Bray, S. A. Ward; Science298, 74 (2002)
[Summary][Full Text]

Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population
O. Niaré et al.; Science298, 213 (2002)
[Abstract][Full Text]

Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium falciparum
S. K. Volkman et al.; Science298, 216 (2002)
[Abstract][Full Text]

MOSQUITO GENOME POSTER

Anopheles gambiae Poster

We offer two online versions of the poster on the malaria mosquito, its genome, and its impact that was included with the 4 October 2002 print issue of Science:

  • An interactive edition (on Science Functional Genomics Web site) with embedded links to online resources and special-issue articles related to the poster's themes.

  • A PDF version (1.6 MB) that can be downloaded and printed out on an 11×17 sheet.

EDITORIAL

The Anopheles gambiae Genome: Completing the Malaria Triad
K. S. Aultman, M. Gottlieb, M. Giovanni, A. S. Fauci; Science298, 13 (2002)
[Full Text]

SPECIAL ISSUE INTRODUCTION

Taking a Genomic Bite of the Malaria Mosquito
B. R. Jasny, O. M. Smith, L. Roberts, M. Enserink; Science298, 77 (2002)
[Full Text]

OPENING VIEWPOINT

The Mosquito Genome -- A Breakthrough for Public Health
C. M. Morel, Y. T. Touré, B. Dobrokhotov, A. M. J. Oduola; Science298, 79 (2002)
[Abstract][Full Text]

NEWS COVERAGE

On Anopheles:

Creatures of Our Own Making
S. Budiansky; Science298, 80 (2002)
[Summary][Full Text]

Meet the Mosquitoes
M. Enserink; Science298 (2002)
[Full text]

Mosquitoes and Disease
Science298, 82 (2002)
[Summary]

In Pursuit of a Killer
G. Vogel; Science298, 87 (2002)
[Summary][Full Text]

What Mosquitoes Want: Secrets of Host Attraction
M. Enserink; Science298, 90 (2002)
[Summary][Full Text]

Lab v. Field: The Case for Studying Real-Life Bugs
M. Enserink; Science298, 92 (2002)
[Summary][Full Text]

An Elegant But Imperfect Tool
G. Vogel; Science298, 94 (2002)
[Summary][Full Text]

On Plasmodium:

Parasite Genome Sequenced, Scrutinized
E. Pennisi; Science298, 33 (2002)
[Summary][Full Text]

VIEWPOINTS

An Overview of Insecticide Resistance
J. Hemingway, L. Field, J. Vontas; Science298, 96 (2002)
[Abstract][Full Text]

The Anopheles Genome and Comparative Insect Genomics
T. C. Kaufman, D. W. Severson, G. E. Robinson; Science298, 97 (2002)
[Abstract][Full Text]

Speciation within Anopheles gambiae -- the Glass is Half Full
A. della Torre et al.; Science298, 115 (2002)
[Abstract][Full Text]

The Ecology of Genetically Modified Mosquitos
T. W. Scott, W. Takken, B. G. J. Knols, C. Boëte; Science298, 117 (2002)
[Abstract][Full Text]

Malaria Control with Genetically Manipulated Vectors
L. Alphey et al.; Science298, 119 (2002)
[Abstract][Full Text]

Malaria -- a Shadow over Africa
L. H. Miller and B. Greenwood; Science298, 121 (2002)
[Abstract][Full Text]

A New Global Effort to Control Malaria
J. D. Sachs; Science298, 122 (2002)
[Abstract][Full Text]

Plasmodium Chloroquine Resistance and the Search for a Replacement Antimalarial Drug
T. E. Wellems; Science298, 124 (2002)
[Abstract][Full Text]

The Plasmodium Falciparum Genome -- a Blueprint for Erythrocyte Invasion
A. F. Cowman and B. S. Crabb; Science298, 126 (2002)
[Abstract][Full Text]

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Cover, Vol. 296, Issue 5565

Apr 5 2002
Vol. 296, No. 5565
"The Rice Genome"

REVIEW

A Draft Sequence of the Rice Genome
(Oryza sativa L. ssp. indica)

J. Yu et al.

[Abstract][Full Text]

A Draft Sequence of the Rice Genome
(Oryza sativa L. ssp. japonica)

S. A. Goff et al.

[Abstract][Full Text]


RICE GENOME POSTER

A downloadable version (in Adobe PDF format) of the poster on rice genomics included with the 5 April 2002 print issue of Science.

Rice Genomics Poster (PDF file; 864 KB)

PERSPECTIVES

The Cereal of the World's Poor Takes Center Stage
R. P. Cantrell and T. G. Reeves; Science296, 53 (2002)
[Summary][Full Text]

World Poverty and Hunger -- The Challenge for Science
I. Serageldin; Science296, 54 (2002)
[Summary][Full Text]

The Most Precious Things Are Not Jade and Pearls . . .
P. Ronald and H. Leung; Science296, 58 (2002)
[Summary][Full Text]

Opening the Door to Comparative Plant Biology
J. Bennetzen; Science296, 60 (2002)
[Summary][Full Text]

EDITORIAL

The Importance of Rice
D. Kennedy; Science296, 13 (2002)
[Full Text]

NEWS FOCUS

Rice: Boiled Down to Bare Essentials
D. Normile and E. Pennisi; Science296, 32 (2002)
[Summary][Full Text]

A Deal for the Rice Genome
E. Marshall; Science296, 34 (2002)
[Summary][Full Text]

From Standing Start to Sequencing Superpower
D. Normile; Science296, 36 (2002)
[Summary][Full Text]

LETTERS

Why Finishing the Rice Genome Matters
J. Leach et al.; Science296, 45 (2002)
[Full Text]

Collaborating on the Rice Genome
S. A. Goff; Science296, 45 (2002)
[Full Text]

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Cover, Vol. 294, Issue 5540

Oct 5 2001
Vol. 294, No. 5540
"Unlocking Biology's Storehouse"

REVIEW

Making Sense of Eukaryotic DNA Replication Origins
David M. Gilbert

[Abstract][Full Text]


VIEWPOINTS

Unlocking the Genome
Barbara R. Jasny and Leslie Roberts
[Summary]

Evolving Genomic Metaphors: A New Look at the Language of DNA
John C. Avise
[Abstract][Full Text]

Harnessing Genomics and Biotechnology to Improve Global Health Equity
Peter A. Singer and Abdallah S. Daar
[Abstract][Full Text]

Global Efforts in Structural Genomics
Raymond C. Stevens, Shigeyuki Yokoyama, and Ian A. Wilson
[Abstract][Full Text]

Protein Structure Prediction and Structural Genomics
David Baker and Andrej Sali
[Abstract][Full Text]

NEWS

So Many Choices, So Little Money
Elizabeth Pennisi
[Summary][Full Text]

Japan and China Gear Up for 'Postgenome' Research
Dennis Normile and Yang Jianxiang
[Summary][Full Text]

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Cover, Vol. 291, Issue 5507

Feb 16 2001
Vol. 291, No. 5507
"The Human Genome"

REVIEW

The Sequence of the Human Genome
J. Craig Venter, Mark D. Adams, Eugene W. Myers, Peter W. Li, Richard J. Mural, Granger G. Sutton, Hamilton O. Smith, Mark Yandell, Cheryl A. Evans, Robert A. Holt, Jeannine D. Gocayne, Peter Amanatides, Richard M. Ballew, Daniel H. Huson, Jennifer Russo Wortman, Qing Zhang, Chinnappa D. Kodira, Xiangqun H. Zheng, Lin Chen, Marian Skupski, Gangadharan Subramanian, Paul D. Thomas, Jinghui Zhang, George L. Gabor Miklos, Catherine Nelson, Samuel Broder, Andrew G. Clark, Joe Nadeau, Victor A. McKusick, Norton Zinder, Arnold J. Levine, Richard J. Roberts, Mel Simon, Carolyn Slayman, Michael Hunkapiller, Randall Bolanos, Arthur Delcher, Ian Dew, Daniel Fasulo, Michael Flanigan, Liliana Florea, Aaron Halpern, Sridhar Hannenhalli, Saul Kravitz, Samuel Levy, Clark Mobarry, Knut Reinert, Karin Remington, Jane Abu-Threideh, Ellen Beasley, Kendra Biddick, Vivien Bonazzi, Rhonda Brandon, Michele Cargill, Ishwar Chandramouliswaran, Rosane Charlab, Kabir Chaturvedi, Zuoming Deng, Valentina Di Francesco, Patrick Dunn, Karen Eilbeck, Carlos Evangelista, Andrei E. Gabrielian, Weiniu Gan, Wangmao Ge, Fangcheng Gong, Zhiping Gu, Ping Guan, Thomas J. Heiman, Maureen E. Higgins, Rui-Ru Ji, Zhaoxi Ke, Karen A. Ketchum, Zhongwu Lai, Yiding Lei, Zhenya Li, Jiayin Li, Yong Liang, Xiaoying Lin, Fu Lu, Gennady V. Merkulov, Natalia Milshina, Helen M. Moore, Ashwinikumar K Naik, Vaibhav A. Narayan, Beena Neelam, Deborah Nusskern, Douglas B. Rusch, Steven Salzberg, Wei Shao, Bixiong Shue, Jingtao Sun, Zhen Yuan Wang, Aihui Wang, Xin Wang, Jian Wang, Ming-Hui Wei, Ron Wides, Chunlin Xiao, Chunhua Yan, Alison Yao, Jane Ye, Ming Zhan, Weiqing Zhang, Hongyu Zhang, Qi Zhao, Liansheng Zheng, Fei Zhong, Wenyan Zhong, Shiaoping C. Zhu, Shaying Zhao, Dennis Gilbert, Suzanna Baumhueter, Gene Spier, Christine Carter, Anibal Cravchik, Trevor Woodage, Feroze Ali, Huijin An, Aderonke Awe, Danita Baldwin, Holly Baden, Mary Barnstead, Ian Barrow, Karen Beeson, Dana Busam, Amy Carver, Angela Center, Ming Lai Cheng, Liz Curry, Steve Danaher, Lionel Davenport, Raymond Desilets, Susanne Dietz, Kristina Dodson, Lisa Doup, Steven Ferriera, Neha Garg, Andres Gluecksmann, Brit Hart, Jason Haynes, Charles Haynes, Cheryl Heiner, Suzanne Hladun, Damon Hostin, Jarrett Houck, Timothy Howland, Chinyere Ibegwam, Jeffery Johnson, Francis Kalush, Lesley Kline, Shashi Koduru, Amy Love, Felecia Mann, David May, Steven McCawley, Tina McIntosh, Ivy McMullen, Mee Moy, Linda Moy, Brian Murphy, Keith Nelson, Cynthia Pfannkoch, Eric Pratts, Vinita Puri, Hina Qureshi, Matthew Reardon, Robert Rodriguez, Yu-Hui Rogers, Deanna Romblad, Bob Ruhfel, Richard Scott, Cynthia Sitter, Michelle Smallwood, Erin Stewart, Renee Strong, Ellen Suh, Reginald Thomas, Ni Ni Tint, Sukyee Tse, Claire Vech, Gary Wang, Jeremy Wetter, Sherita Williams, Monica Williams, Sandra Windsor, Emily Winn-Deen, Keriellen Wolfe, Jayshree Zaveri, Karena Zaveri, Josep F. Abril, Roderic Guigó, Michael J. Campbell, Kimmen V. Sjolander, Brian Karlak, Anish Kejariwal, Huaiyu Mi, Betty Lazareva, Thomas Hatton, Apurva Narechania, Karen Diemer, Anushya Muruganujan, Nan Guo, Shinji Sato, Vineet Bafna, Sorin Istrail, Ross Lippert, Russell Schwartz, Brian Walenz, Shibu Yooseph, David Allen, Anand Basu, James Baxendale, Louis Blick, Marcelo Caminha, John Carnes-Stine, Parris Caulk, Yen-Hui Chiang, My Coyne, Carl Dahlke, Anne Deslattes Mays, Maria Dombroski, Michael Donnelly, Dale Ely, Shiva Esparham, Carl Fosler, Harold Gire, Stephen Glanowski, Kenneth Glasser, Anna Glodek, Mark Gorokhov, Ken Graham, Barry Gropman, Michael Harris, Jeremy Heil, Scott Henderson, Jeffrey Hoover, Donald Jennings, Catherine Jordan, James Jordan, John Kasha, Leonid Kagan, Cheryl Kraft, Alexander Levitsky, Mark Lewis, Xiangjun Liu, John Lopez, Daniel Ma, William Majoros, Joe McDaniel, Sean Murphy, Matthew Newman, Trung Nguyen, Ngoc Nguyen, Marc Nodell, Sue Pan, Jim Peck, Marshall Peterson, William Rowe, Robert Sanders, John Scott, Michael Simpson, Thomas Smith, Arlan Sprague, Timothy Stockwell, Russell Turner, Eli Venter, Mei Wang, Meiyuan Wen, David Wu, Mitchell Wu, Ashley Xia, Ali Zandieh, and Xiaohong Zhu

[Abstract][Full Text]

Web Fig. 1: Annotation of the Celera Human Genome Assembly


REVIEW

Apoptotic Molecular Machinery: Vastly Increased Complexity in Vertebrates Revealed by Genome Comparisons
L. Aravind, Vishva M. Dixit, and Eugene V. Koonin
[Abstract][Full Text]

Human DNA Repair Genes
Richard D. Wood, Michael Mitchell, John Sgouros, and Tomas Lindahl
[Abstract][Full Text]

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains
Huib Caron, Barbera van Schaik, Merlijn van der Mee, Frank Baas, Gregory Riggins, Peter van Sluis, Marie-Christine Hermus, Ronald van Asperen, Kathy Boon, P. A. Vo±te, Siem Heisterkamp, Antoine van Kampen, and Rogier Versteeg
[Abstract][Full Text]

Birth of Two Chimeric Genes in the Hominidae Lineage
Anouk Courseaux and Jean-Louis Nahon
[Abstract][Full Text]

A High-Resolution Radiation Hybrid Map of the Human Genome Draft Sequence
Michael Olivier, Amita Aggarwal, Jennifer Allen, Annalisa A. Almendras, Eva S. Bajorek, Ellen M. Beasley, Shannon D. Brady, Jannette M. Bushard, Valerie I. Bustos, Angela Chu, Tisha R. Chung, Anniek De Witte, Mirian E. Denys, Rakly Dominguez, Nicole Y. Fang, Brian D. Foster, Robert W. Freudenberg, David Hadley, Libby R. Hamilton, Tonya J. Jeffrey, Libusha Kelly, Laura Lazzeroni, Michelle R. Levy, Saskia C. Lewis, Xia Liu, Frederick J. Lopez, Brent Louie, Joseph P. Marquis, Robert A. Martinez, Margaret K. Matsuura, Nedda S. Misherghi, Jolanna A. Norton, Adam Olshen, Shanti M. Perkins, Amy J. Perou, Chris Piercy, Mark Piercy, Fawn Qin, Tim Reif, Kelly Sheppard, Vida Shokoohi, Geoff A. Smick, Wei-Lin Sun, Elizabeth A. Stewart, J. Fernando, Tejeda, Nguyet M. Tran, Tonatiuh Trejo, Nu T. Vo, Simon C. M. Yan, Deborah L. Zierten, Shaying Zhao, Ravi Sachidanandam, Barbara J. Trask, Richard M. Myers, and David R. Cox
[Abstract][Full Text]

VIEWPOINTS

The Human Genome
Barbara R. Jasny and Donald Kennedy
[Full Text]

GENOMICS AND SOCIETY: The Human Genome and Our View of Ourselves
Svante Pääbo
[Summary][Full Text]

PROTEOMICS: Proteomics in Genomeland
Stanley Fields
[Abstract][Full Text]

GENOMICS AND MEDICINE: Dissecting Human Disease in the Postgenomic Era
Leena Peltonen and Victor A. McKusick
[Abstract][Full Text]

GENOMICS AND BEHAVIOR: Toward Behavioral Genomics
Peter McGuffin, Brien Riley, and Robert Plomin
[Abstract][Full Text]

POLICY ISSUES: Political Issues in the Genome Era
James M. Jeffords and Tom Daschle
[Abstract][Full Text]

SEQUENCE INTERPRETATION: Functional Annotation of Mouse Genome Sequences
Joseph H. Nadeau, Rudi Balling, Greg Barsh, David Beier, S. D. M. Brown, Maja Bucan, Sally Camper, George Carlson, Neal Copeland, Janan Eppig, Colin Fletcher, Wayne N. Frankel, Detlev Ganten, Dan Goldowitz, Chris Goodnow, Jean-Louis Guenet, Geoff Hicks, Martin Hrabe de Angelis, Ian Jackson, Howard J. Jacob, Nancy Jenkins, Dabney Johnson, Monica Justice, Steve Kay, David Kingsley, Hans Lehrach, Terry Magnuson, Miriam Meisler, AnneMarie Poustka, Eugene M. Rinchik, Janet Rossant, Lee B. Russell, John Schimenti, Toshihiko Shiroishi, William C. Skarnes, Phil Soriano, William Stanford, Joseph S. Takahashi, Wolfgang Wurst, and Andreas Zimmer
[Abstract][Full Text]

GENE NUMBER: What If There Are Only 30,000 Human Genes?
Jean-Michel Claverie
[Abstract][Full Text]

SEQUENCE INTERPRETATION: Making Sense of the Sequence
David J. Galas
[Abstract][Full Text]

COMPUTATIONAL BIOLOGY: Bioinformatics--Trying to Swim in a Sea of Data
David S. Roos
[Abstract][Full Text]

NEWS

A History of the Human Genome Project
Leslie Roberts, R. John Davenport, Elizabeth Pennisi, and Eliot Marshall
[Summary][Full Text]

A Genome Glossary
Laura Helmuth
[Summary][Full Text]

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Cover, Vol. 287, Issue 5461

Mar 24 2000
Vol. 287, No. 5461
"The Drosophila Genome"

REVIEW

The Genome Sequence of Drosophila melanogaster
Mark D. Adams, Susan E. Celniker, Robert A. Holt, Cheryl A. Evans, Jeannine D. Gocayne, Peter G. Amanatides, Steven E. Scherer, Peter W. Li, Roger A. Hoskins, Richard F. Galle, Reed A. George, Suzanna E. Lewis, Stephen Richards, Michael Ashburner, Scott N. Henderson, Granger G. Sutton, Jennifer R. Wortman, Mark D. Yandell, Qing Zhang, Lin X. Chen, Rhonda C. Brandon, Yu-Hui C. Rogers, Robert G. Blazej, Mark Champe, Barret D. Pfeiffer, Kenneth H. Wan, Clare Doyle, Evan G. Baxter, Gregg Helt, Catherine R. Nelson, George L. Gabor, Miklos, Josep F. Abril, Anna Agbayani, Hui-Jin An, Cynthia Andrews-Pfannkoch, Danita Baldwin, Richard M. Ballew, Anand Basu, James Baxendale, Leyla Bayraktaroglu, Ellen M. Beasley, Karen Y. Beeson, P. V. Benos, Benjamin P. Berman, Deepali Bhandari, Slava Bolshakov, Dana Borkova, Michael R. Botchan, John Bouck, Peter Brokstein, Phillipe Brottier, Kenneth C. Burtis, Dana A. Busam, Heather Butler, Edouard Cadieu, Angela Center, Ishwar Chandra, J. Michael Cherry, Simon Cawley, Carl Dahlke, Lionel B. Davenport, Peter Davies, Beatriz de Pablos, Arthur Delcher, Zuoming Deng, Anne Deslattes Mays, Ian Dew, Suzanne M. Dietz, Kristina Dodson, Lisa E. Doup, Michael Downes, Shannon Dugan-Rocha, Boris C. Dunkov, Patrick Dunn, Kenneth J. Durbin, Carlos C. Evangelista, Concepcion Ferraz, Steven Ferriera, Wolfgang Fleischmann, Carl Fosler, Andrei E. Gabrielian, Neha S. Garg, William M. Gelbart, Ken Glasser, Anna Glodek, Fangcheng Gong, J. Harley Gorrell, Zhiping Gu, Ping Guan, Michael Harris, Nomi L. Harris, Damon Harvey, Thomas J. Heiman, Judith R. Hernandez, Jarrett Houck, Damon Hostin, Kathryn A. Houston, Timothy J. Howland, Ming-Hui Wei, Chinyere Ibegwam, Mena Jalali, Francis Kalush, Gary H. Karpen, Zhaoxi Ke, James A. Kennison, Karen A. Ketchum, Bruce E. Kimmel, Chinnappa D. Kodira, Cheryl Kraft, Saul Kravitz, David Kulp, Zhongwu Lai, Paul Lasko, Yiding Lei, Alexander A. Levitsky, Jiayin Li, Zhenya Li, Yong Liang, Xiaoying Lin, Xiangjun Liu, Bettina Mattei, Tina C. McIntosh, Michael P. McLeod, Duncan McPherson, Gennady Merkulov, Natalia V. Milshina, Clark Mobarry, Joe Morris, Ali Moshrefi, Stephen M. Mount, Mee Moy, Brian Murphy, Lee Murphy, Donna M. Muzny, David L. Nelson, David R. Nelson, Keith A. Nelson, Katherine Nixon, Deborah R. Nusskern, Joanne M. Pacleb, Michael Palazzolo, Gjange S. Pittman, Sue Pan, John Pollard, Vinita Puri, Martin G. Reese, Knut Reinert, Karin Remington, Robert D. C. Saunders, Frederick Scheeler, Hua Shen, Bixiang Christopher Shue, Inga Sidén-Kiamos, Michael Simpson, Marian P. Skupski, Tom Smith, Eugene Spier, Allan C. Spradling, Mark Stapleton, Renee Strong, Eric Sun, Robert Svirskas, Cyndee Tector, Russell Turner, Eli Venter, Aihui H. Wang, Xin Wang, Zhen-Yuan Wang, David A. Wassarman, George M. Weinstock, Jean Weissenbach, Sherita M. Williams, Trevor Woodage, Kim C. Worley, David Wu, Song Yang, Q. Alison Yao, Jane Ye, Ru-Fang Yeh, Jayshree S. Zaveri, Ming Zhan, Guangren Zhang, Qi Zhao, Liansheng Zheng, Xiangqun H. Zheng, Fei N. Zhong, Wenyan Zhong, Xiaojun Zhou, Shiaoping Zhu, Xiaohong Zhu, Hamilton O. Smith, Richard A. Gibbs, Eugene W. Myers, Gerald M. Rubin, and J. Craig Venter

[Abstract][Full Text]

Coding Content of the Drosophila Genome


REVIEW

A Whole-Genome Assembly of Drosophila
Eugene W. Myers, Granger G. Sutton, Art L. Delcher, Ian M. Dew, Dan P. Fasulo, Michael J. Flanigan, Saul A. Kravitz, Clark M. Mobarry, Knut H. J. Reinert, Karin A. Remington, Eric L. Anson, Randall A. Bolanos, Hui-Hsien Chou, Catherine M. Jordan, Aaron L. Halpern, Stefano Lonardi, Ellen M. Beasley, Rhonda C. Brandon, Lin Chen, Patrick J. Dunn, Zhongwu Lai, Yong Liang, Deborah R. Nusskern, Ming Zhan, Qing Zhang, Xiangqun Zheng, Gerald M. Rubin, Mark D. Adams, and J. Craig Venter
[Abstract][Full Text]

Comparative Genomics of the Eukaryotes
Gerald M. Rubin, Mark D. Yandell, Jennifer R. Wortman, George L. Gabor, Miklos, Catherine R. Nelson, Iswar K. Hariharan, Mark E. Fortini, Peter W. Li, Rolf Apweiler, Wolfgang Fleischmann, J. Michael Cherry, Steven Henikoff, Marian P. Skupski, Sima Misra, Michael Ashburner, Ewan Birney, Mark S. Boguski, Thomas Brody, Peter Brokstein, Susan E. Celniker, Stephen A. Chervitz, David Coates, Anibal Cravchik, Andrei Gabrielian, Richard F. Galle, William M. Gelbart, Reed A. George, Lawrence S. B. Goldstein, Fangcheng Gong, Ping Guan, Nomi L. Harris, Bruce A. Hay, Roger A. Hoskins, Jiayin Li, Zhenya Li, Richard O. Hynes, S. J. M. Jones, Peter M. Kuehl, Bruno Lemaitre, J. Troy Littleton, Deborah K. Morrison, Chris Mungall, Patrick H. O'Farrell, Oxana K. Pickeral, Chris Shue, Leslie B. Vosshall, Jiong Zhang, Qi Zhao, Xiangqun H. Zheng, Fei Zhong, Wenyan Zhong, Richard Gibbs, J. Craig Venter, Mark D. Adams, and Suzanna Lewis
[Abstract][Full Text]

The Universe of Drosophila Genes
Barbara R. Jasny
[Summary]

A BAC-Based Physical Map of the Major Autosomes of Drosophila melanogaster
Roger A. Hoskins, Catherine R. Nelson, Benjamin P. Berman, Todd R. Laverty, Reed A. George, Lisa Ciesiolka, Mohammed Naeemuddin, Andrew D. Arenson, James Durbin, Robert G. David, Paul E. Tabor, Michael R. Bailey, Denise R. DeShazo, Joseph Catanese, Aaron Mammoser, Kazutoyo Osoegawa, Pieter J. de, Jong, Susan E. Celniker, Richard A. Gibbs, Gerald M. Rubin, and Steven E. Scherer
[Abstract][Full Text]

VIEWPOINTS

Flying to New Heights
Barbara R. Jasny and Floyd E. Bloom
[Full Text]

GENOMICS:The End of the Beginning
Sydney Brenner
[Summary][Full Text]

A Brief History of Drosophila's Contributions to Genome Research
Gerald M. Rubin and Edward B. Lewis
[Abstract][Full Text]

The Drosophila Genome Sequence: Implications for Biology and Medicine
Thomas B. Kornberg and and Mark A. Krasnow
[Abstract][Full Text]

From Sequence to Chromosome: The Tip of the X Chromosome of D. melanogaster
Panayiotis V. Benos, Melanie K. Gatt, Michael Ashburner, Lee Murphy, David Harris, Bart Barrell, Concepcion Ferraz, Sophie Vidal, Christine Brun, Jacques Demailles, Edouard Cadieu, Stephane Dreano, Stéphanie Gloux, Valerie Lelaure, Stephanie Mottier, Francis Galibert, Dana Borkova, Belen Minana, Fotis C. Kafatos, Christos Louis, Inga Sidén-Kiamos, Slava Bolshakov, George Papagiannakis, Lefteris Spanos, Sarah Cox, Encarnación Madueño, Beatriz de Pablos, Juan Modolell, Annette Peter, Petra Schöttler, Meike Werner, Foteini Mourkioti, Nicole Beinert, Gordon Dowe, Ulrich Schäfer, Herbert Jäckle, Alain Bucheton, Deborah M. Callister, Lorna A. Campbell, Areti Darlamitsou, Nadine S. Henderson, Paul J. McMillan, Cathy Salles, Evelyn A. Tait, Phillipe Valenti, Robert D. C., Saunders, and David M. Glover
[Abstract][Full Text]

A Drosophila Complementary DNA Resource
Gerald M. Rubin, Ling Hong, Peter Brokstein, Martha Evans-Holm, Erwin Frise, Mark Stapleton, and Damon A. Harvey
[Abstract][Full Text]

NEWS

Ideas Fly at Gene-Finding Jamboree
Elizabeth Pennisi
[Summary][Full Text]

Are Sequencers Ready to 'Annotate' the Human Genome?
Elizabeth Pennisi
[Summary][Full Text]

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Cover, Vol. 286, Issue 5439

Oct 15 1999
Vol. 286, No. 5439
"Genome"

REVIEW

The Promise of Comparative Genomics in Mammals
Stephen J. O'Brien, Marilyn Menotti-Raymond, William J. Murphy, William G. Nash, Johannes Wienberg, Roscoe Stanyon, Neal G. Copeland, Nancy A. Jenkins, James E. Womack, Jennifer A. Marshall Graves

[Abstract][Full Text]


REVIEW

Epigenetics:
Regulation Through Repression

Alan P. Wolffe, Marjori A. Matzke
[Abstract][Full Text]

Pharmacogenomics:
Translating Functional Genomics into Rational Therapeutics

William E. Evans, Mary V. Relling
[Abstract][Full Text]

Comparative Genomics Mammalian Radiations Genome Maps 10[Full Text]

VIEWPOINTS

Genomic Views of Human History
Kelly Owens, Mary-Claire King
[Abstract][Full Text]

Biosequence Exegesis
Mark S. Boguski
[Abstract][Full Text]

The Mammalian Gene Collection
Robert L. Strausberg, Elise A. Feingold, Richard D. Klausner, Francis S. Collins
[Abstract][Full Text]

NEWS

Do-It-Yourself Gene Watching
Eliot Marshall
[Summary][Full Text]

Keeping Genome Databases Clean and Up to Date
Elizabeth Pennisi
[Summary][Full Text]

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Cover

Dec 11 1998
Vol. 282, No. 5396
"C. Elegans: Sequence to Biology"

REVIEW

Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology
The C. elegans Sequencing Consortium

[Abstract][Full Text]


REVIEW

Zinc Fingers in Caenorhabditis elegans: Finding Families and Probing Pathways
Neil D. Clarke and Jeremy M. Berg
[Summary][Full Text]

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence
Stephen A. Chervitz, L. Aravind, Gavin Sherlock, Catherine A. Ball, Eugene V. Koonin, Selina S. Dwight, Midori A. Harris, Kara Dolinski, Scott Mohr, Temple Smith, Shuai Weng, J. Michael Cherry, and David Botstein
[Summary][Full Text]

Neurobiology of the Caenorhabditis elegans Genome
Cornelia I. Bargmann
[Summary][Full Text]

The Taxonomy of Developmental Control in Caenorhabditis elegans
Gary Ruvkun and Oliver Hobert
[Summary][Full Text]

Caenorhabditis elegans Is a Nematode
Mark Blaxter
[Summary][Full Text]

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Cover, Vol. 282 Issue 5389

Oct 23 1998
Vol. 282, No. 5389
"Genome Issue: A Genome Sampler"

REVIEW

Arabidopsis thaliana: A Model Plant for Genome Analysis
David W. Meinke, J. Michael Cherry, Caroline Dean, Steven D. Rounsley, and Maarten Koornneef

[Abstract][Full Text]


REVIEW

Arabidopsis thaliana Genome Maps 9
[Full Text]

New Goals for the U.S. Human Genome Project: 1998-2003
Francis S. Collins, Ari Patrinos, Elke Jordan, Aravinda Chakravarti, Raymond Gesteland, LeRoy Walters, and the members of the DOE and NIH planning groups
[Abstract][Full Text]


A Genome Sampler
Barbara R. Jasny and Pamela J. Hines
[Full Text]

VIEWPOINTS

Plant Comparative Genetics after 10 Years
M. D. Gale and K. M. Devos
[Abstract][Full Text]

Databases in Genomic Research
William M. Gelbart
[Abstract][Full Text]

NEWS

PLANT GENOMICS:
A Bonanza for Plant Genomics

Elizabeth Pennisi
[Summary][Full Text]

PLANT GENOMICS: Slow Start for U.S. Rice Genome Project
[Summary][Full Text]

CULTURAL ANTHROPOLOGY: DNA Studies Challenge the Meaning of Race
Eliot Marshall
[Summary][Full Text]

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Cover, Vol. 278 Issue 5338

Oct 24 1997
Vol. 278, No. 5338
"Genome Issue: Building Gene Families"

REVIEW

Gene Families: The Taxonomy of Protein Paralogs and Chimeras
Steven Henikoff, Elizabeth A. Greene, Shmuel Pietrokovski, Peer Bork, Teresa K. Attwood, and Leroy Hood

[Abstract][Full Text]


REVIEW

Gene Families: The Taxonomy of Protein Paralogs and Chimeras.
Steven Henikoff, Elizabeth A. Greene, Shmuel Pietrokovski, Peer Bork, Teresa K. Attwood, and Leroy Hood
[Abstract][Full Text]

GENOME MAPS 8: Building Gene Families.
[Summary][Full Text]

A Genomic Perspective on Protein Families.
Roman L. Tatusov, Eugene V. Koonin, and David J. Lipman
[Abstract][Full Text]

Functional Coherence of the Human Y Chromosome.
Bruce T. Lahn and David C. Page
[Abstract][Full Text]

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale.
Joseph L. DeRisi, Vishwanath R. Iyer, and Patrick O. Brown
[Abstract][Full Text]

VIEWPOINTS

Functional Genomics: It's All How You Read It.
Philip Hieter and Mark Boguski
[Abstract][Full Text]

Predictive Genetic Testing: From Basic Research to Clinical Practice.
Neil A. Holtzman, Patricia D. Murphy, Michael S. Watson, and Patricia A. Barr
[Abstract][Full Text]
Sequencing the Human Genome.
Lee Rowen, Gregory Mahairas, and Leroy Hood
[Abstract][Full Text]

NEWS

BIOMEDICAL POLICY: Whose DNA Is It, Anyway?
Eliot Marshall
[Summary][Full Text]

HUMAN GENETICS: NRC OKs Long-Delayed Survey of Human Genome Diversity.
Elizabeth Pennisi
[Summary][Full Text]

HUMAN GENETICS: Environment Institute Lays Plans for Gene Hunt.
Jocelyn Kaiser
[Summary][Full Text]

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Cover, Vol. 274 Issue 5287

Oct 25 1996
Vol. 274, No. 5287
"The Genome Issue"

REVIEW

A Gene Map of the Human Genome
G. D. Schuler, M. S. Boguski, E. A. Stewart, L. D. Stein, G. Gyapay, K. Rice, R. E. White, P. Rodriguez-Tom±, A. Aggarwal, E. Bajorek, S. Bentolila, B. B. Birren, A. Butler, A. B. Castle, N. Chiannilkulchai, A. Chu, C. Clee, S. Cowles, P. J. R. Day, T. Dibling, C. East, N. Drouot, I. Dunham, S. Duprat, C. Edwards, J.-B. Fan, N. Fang, C. Fizames, C. Garrett, L. Green, D. Hadley, M. Harris, P. Harrison, S. Brady, A. Hicks, E. Holloway, L. Hui, S. Hussain, C. Louis-Dit-Sully, J. Ma, A. MacGilvery, C. Mader, A. Maratukulam, T. C. Matise, K. B. McKusick, J. Morissette, A. Mungall, D. Muselet, H. C. Nusbaum, D. C. Page, A. Peck, S. Perkins, M. Piercy, F. Qin, J. Quackenbush, S. Ranby, T. Reif, S. Rozen, C. Sanders, X. She, J. Silva, D. K. Slonim, C. Soderlund, W.-L. Sun, P. Tabar, T. Thangarajah, N. Vega-Czarny, D. Vollrath, S. Voyticky, T. Wilmer, X. Wu, M. D. Adams, C. Auffray, N. A. R. Walter, R. Brandon, A. Dehejia, P. N. Goodfellow, R. Houlgatte, J. R. Hudson Jr., S. E. Ide, K. R. Iorio, W. Y. Lee, N. Seki, T. Nagase, K. Ishikawa, N. Nomura, C. Phillips, M. H. Polymeropoulos, M. Sandusky, K. Schmitt, R. Berry, K. Swanson, R. Torres, J. C. Venter, J. M. Sikela, J. S. Beckmann, J. Weissenbach, R. M. Myers, D. R. Cox, M. R. James, D. Bentley, P. Deloukas, E. S. Lander, T. J. Hudson

[Abstract][Full Text]

[Web Site] Have You Ever Wanted to Play With a Genome?
B. Jasny


REVIEW

Life with 6000 Genes.
A. Goffeau, B. G. Barrell, H. Bussey, R. W. Davis, B. Dujon, H. Feldmann, F. Galibert, J. D. Hoheisel, C. Jacq, M. Johnston, E. J. Louis, H. W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, and S. G. Oliver
[Abstract][Full Text]

Accessing Genetic Information with High-Density DNA Arrays.
Mark Chee, Robert Yang, Earl Hubbell, Anthony Berno, Xiaohua C. Huang, David Stern, Jim Winkler, David J. Lockhart, Macdonald S. Morris, and Stephen P. A. Fodor
[Abstract][Full Text]

Genetic Discrimination: Perspectives of Consumers.
E. Virginia Lapham, Chahira Kozma, and Joan O. Weiss
[Abstract][Full Text]

VIEWPOINTS

Landing on the Genome.
Jean Weissenbach [Summary]

Genomic Sequence Information Should Be Released Immediately and Freely in the Public Domain.
David R. Bentley
[Summary][Full Text]

Should Non-Peer-Reviewed Raw DNA Sequence Data Release Be Forced on the Scientific Community?
Mark D. Adams and J. Craig Venter
[Summary][Full Text]

The New Genomics: Global Views of Biology.
Eric S. Lander
[Summary][Full Text]

NEWS

Genetics: The Genome Program's Conscience.
Eliot Marshall
[Summary][Full Text]

Genome: Coming to Grips With Genes and Risk.
Patricia Kahn [Summary][Full Text]

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Cover, Vol. 270 Issue 5235

Oct 20 1995
Vol. 270, No. 5235
"Genome Issue"

REVIEW

The Minimal Gene Complement of Mycoplasma genitalium
C. M. Fraser, J. D. Gocayne, O. White, M. D. Adams, R. A. Clayton, R. D. Fleischmann, C. J. Bult, A. R. Kerlavage, G. Sutton, J. M. Kelley, J. L. Fritchman, J. F. Weidman, K. V. Small, M. Sandusky, J. Fuhrmann, D. Nguyen, T. R. Utterback, D. M. Saudek, C. A. Phillips, J. M. Merrick, J.-F. Tomb, B. A. Dougherty, K. F. Bott, P.-C. Hu, T. S. Lucier

[Abstract][PDF]


REVIEW

Transfer of Genes to Humans: Early Lessons and Obstacles to Success.
Ronald G. Crystal
[Abstract][PDF]

The Nematode Caenorhabditis elegans and Its Genome.
Jonathan Hodgkin, Ronald H. A. Plasterk, and Robert H. Waterston
[Abstract][PDF]

Genome Map 1995.

[Summary]

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray.
Mark Schena, Dari Shalon, Ronald W. Davis, and Patrick O. Brown
[Abstract]

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA- Immunodeficient Patients.
Claudio Bordignon, Luigi D. Notarangelo, Nadia Nobili, Giuliana Ferrari, Giulia Casorati, Paola Panina, Evelina Mazzolari, Daniela Maggioni, Claudia Rossi, Paolo Servida, Alberto G. Ugazio, and Fulvio Mavilio
[Abstract]

T Lymphocyte-Directed Gene Therapy for ADA- SCID: Initial Trial Results After 4 Years.
R. Michael Blaese, Kenneth W. Culver, A. Dusty Miller, Charles S. Carter, Thomas Fleisher, Mario Clerici, Gene Shearer, Lauren Chang, Yawen Chiang, Paul Tolstoshev, Jay J. Greenblatt, Steven A. Rosenberg, Harvey Klein, Melvin Berger, Craig A. Mullen, W. Jay Ramsey, Linda Muul, Richard A. Morgan, and W. French Anderson
[Abstract]

Physical Map and Organization of Arabidopsis thaliana Chromosome 4.
Renate Schmidt, Joanne West, Karina Love, Zoë Lenehan, Clare Lister, Helen Thompson, David Bouchez, and Caroline Dean
[Abstract]

Serial Analysis of Gene Expression.
Victor E. Velculescu, Lin Zhang, Bert Vogelstein, and Kenneth W. Kinzler
[Abstract]

VIEWPOINTS

In Transition.
Barbara R. Jasny
[Summary]

Genetic Discrimination and Health Insurance: An Urgent Need for Reform.
Kathy L. Hudson, Karen H. Rothenberg, Lori B. Andrews, Mary Jo Ellis Kahn, and Francis S. Collins
[Summary][PDF]

A Time to Sequence.
Maynard V. Olson
[Summary][PDF]

ENHANCED PERSPECTIVE: Life With 482 Genes.
André Goffeau
[Summary][Full Text]

NEWS

Genetics: Entering the Postgenome Era.
Rachel Nowak
[Summary]

Molecular Biology: From Genome to Proteome: Looking at a Cell's Proteins.
Patricia Kahn [Summary]

Page Top

Earlier Articles -- from 1994

Assessing Mapping Progress in the Human Genome Project
David R. Cox, Eric D. Green, Eric S. Lander, Daniel Cohen, Richard M. Meyers
Science, 30 September 1994, v. 265 (5181): 2031-2032
[PDF]

A Database for Mouse Development
Martin Ringwald, Richard Baldock, Jonathan Bard, Matthew Kaufman, Janan T. Eppig, Joel E. Richardson, Joseph H. Nadeau, Duncan Davidson
Science, 30 September 1994, v. 265 (5181): 2033-2034
[PDF]

The Human Genome Project: Under an International Ethical Microscope
Bartha Maria Knoppers and Ruth Chadwick
Science, 30 September 1994, v. 265 (5181): 2035-2036
[PDF]

Genetic Dissection of Complex Traits
Eric S. Lander and Nicholas J. Schork
Science, 30 September 1994, v. 265 (5181): 2037-2048
[PDF]

A Comprehensive Human Linkage Map with Centimorgan Density
Cooperative Human Linkage Center (CHLC): Jeffrey C. Murray, Kenneth H. Buetow, James L. Weber, Susan Ludwigsen, Titia Scherpbier-Heddema, Frank Manion, John Quillen, Val C. Sheffield, Sara Sunden, Geoffrey M. Duyk; Genethon: G. Mark Lathrop, Alain Vignal; University of Utah: Ray White, Norisada Matsunami, Steven Gerken, Roberta Melis, Hans Albertsen, Rosmarie Plaetke, Shannon Odelberg; Yale University: David Ward; Centre d'Etude du Polymorphisme Humain (CEPH): Jean Dausset, Daniel Cohen, Howard Cann
Science, 30 September 1994, v. 265 (5181): 2049-2054
[PDF]


Earlier Articles -- from 1993

A New Five-Year Plan for the U.S. Human Genome Project
Francis Collins and David Galas
Science, 1 October 1993, v. 262 (5130): 43-46
[PDF]

Managing All Those Bytes: The Human Genome Project
A. Jamie Cuticchia, Michael A. chipperfield, Christopher J. porter, William Kearns, Peter L. Pearson
Science, 1 October 1993, v. 262 (5130): 47-48
[PDF]

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects
Neal G. Copeland, Nancy A. Jenkins, Debra J. Gilbert, Janan T. Eppig, Lois J. Maltais, Joyce C. Miller, William F. Dietrich, Alix Weaver, Stephen E. Lincoln, Robert G. Steen, Lincoln D. Stein, Joseph H. Nadeau, Eric S. Lander
Science, 1 October 1993, v. 262 (5130): 57-65
[PDF]


Earlier Articles -- from 1992

Hidden Messages in Genetic Maps
Christine J. Farr and Peter N. Goodfellow
Science, 2 October 1992, v. 258 (5079): 49
[PDF]

The Human Y Chromosome: A 43-Interval Map Based on Naturally Occurring Deletions Douglas Vollrath, Simon Foote, Adrienne Hilton, Laura G. Brown, Peggy Beer-Romero, Jonathan S. Brogan, David C. Page
Science, 2 October 1992, v. 258 (5079): 52-59
[PDF]

The Human Y Chromosome: Overlapping DNA Clones Spanning the Euchromatic Region
Simon Foote, Douglas Vollrath, Adrienne Hilton, David C. Page
Science, 2 October 1992, v. 258 (5079): 60-66
[PDF]

A Comprehensive Genetic Linkage Map of the Human Genome
NIH/CEPH Collaborative Mapping Group
Science, 2 October 1992, v. 258 (5079): 67-86
[PDF]

Genome Analysis and the Human X Chromosome
Jean-Louis Mandel, Anthony P. Monaco, David J. Jelson, David Schlessinger, Huntington Willard
Science, 2 October 1992, v. 258 (5079): 103-109
[PDF]


Earlier Articles -- from 1991

The Human Genome Initiative-Do Databases Reflect Current Progress?
P. L. Pearson, B. Maidak, M. Chipperfield, R. Robbins
Science, 11 October 1991, v. 254 (5029): 214-215
[PDF]

Toward Cloning and Mapping the Genome of Drosophila
J. Merriam, M. Ashburner, D. L. Hartl, F. C. Kafatos
Science, 11 October 1991, v. 254 (5029): 221-225
[PDF]


Earlier Articles -- from 1990

Mapping the Human Genome: Current Status
J. Claiborne Stephens, Mark L. Cavanaugh, Margaret I. Gradie, Martin L. Mador, Kenneth K. Kidd
Science, 12 October 1990, v. 250 (4978): 237-244
[PDF]

Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian Chromosomes
David R. Cox, Margit Burmeister, E. Roydon Price, Suwon Kim, Richard M. Myers
Science, 12 October 1990, v. 250 (4978): 246-250
[PDF]

Page Top



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