Mapping RNA Form and Function
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In Science Magazine
In Science's STKE
In Science's SAGE KE

Science Magazine and its online Knowledge Environments weave through the multilayered world of RNA in a special collection of articles published with the 2 September 2005 issue. In Science, Review and Viewpoint articles cover the relationship between RNA structure and function, the emerging "big world" of small RNAs, noncoding RNAs, and other aspects of this remarkable molecule; also in the issue are eleven new research papers touching various aspects of RNA. In addition, an accompanying pull-out poster limns the role of small RNAs in gene silencing. Science's Signal Transduction Knowledge Environment presents articles and an animation further exploring the roles of RNA in genomic complexity and regulation of gene expression. And the Science of Aging Knowledge Environment looks at how RNA interference has affected aging research in a key model system, the worm.

In Science

Capping by Branching: A New Ribozyme Makes Tiny Lariats
A. M. Pyle

Also in this issue:
Eleven new research papers on RNA, RNAi, transcription, and related topics



And . . .
Poster: RNA Silencing

RNA poster detail

A downloadable PDF version of the pull-out poster (sponsored by Ambion) featured in this special issue.


In STKE

EDITORIAL GUIDE

Focus Issue -- RNA, A Multifunctional Molecule
N. R. Gough and E. M. Adler
RNA increases genomic complexity and regulates gene expression.
PERSPECTIVE

MicroRNA-Dependent Trans-Acting siRNA Production
H. Vaucheret
A new class of endogenous small RNAs, tasiRNAs, establishes a link between the miRNA and siRNA pathways.

TEACHING RESOURCES

A Journal-Club Discussion of Regulation by MicroRNA
D. C. Weinstein
Design a student discussion to critically evaluate the primary literature regarding microRNA.
A Model for Local Regulation of Translation Near Active Synapses
K. S. Kosik and A. M. Krichevsky
This animation illustrates how RNA granules may contribute to synaptic plasticity.

In Science's SAGE KE


PERSPECTIVE

Interfering with Longevity
S. S. Lee
RNA interference has transformed aging-related research in worms.