Special Online Collection: Crossing Membranes

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MembranesThe lipid bilayer of the cell membrane constitutes the boundary between the cell and the rest of the world -- and, as such, acts as the key gateway for communications between the cell and its environment. A special collection of articles in Science and its online companion Signal Transduction Knowledge Environment (STKE) explores the current understanding of ion and macromolecule transport across these semipermeable membranes. In Science, Review articles examines the mechanisms that cells use to allow proteins, DNA, and ions to cross biological membranes both within the cell (for example, among organelles) and in transfers between the cell and its environment. And a set of articles in STKE addresses how information is transmitted across cell membranes to contribute to cell signaling processes.

In Science

INTRODUCTION

Crossing the Bilayer
S. M. Hurtley

REVIEWS

Protein Translocation Across Biological Membranes
W. Wickner and R. Schekman
The Ins and Outs of DNA Transfer in Bacteria
I. Chen, P. J. Christie, D. Dubnau
Principles of Selective Ion Transport in Channels and Pumps
E. Gouaux and R. MacKinnon

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue -- Signaling Across Membranes
N. R. Gough
Intracellular responses rely on information transmitted across cellular membranes.

Perspectives

Novel Compartment Implicated in Calcium Signaling -- Is It an "Induced Coupling Domain"?
C. Hisatsune and K. Mikoshiba
Clustering of STIM and IP3 receptors may be involved in store-operated or receptor-operated calcium entry.
Transduction Peptides Within Naturally Occurring Proteins
A. Joliot
Transduction peptide sequences bring proteins across biological membranes.
Long-Distance Calls Between Cells Connected by Tunneling Nanotubules
B. Önfelt, M. A. Purbhoo, S. Nedvetzki, S. Sowinski, D. M. Davis
Membrane nanotubules provide a possible mechanism for information transfer between cells.

TEACHING RESOURCE

Regulation of Complexes by Cytoskeletal Elements -- Integrins Serve as Force Transducers Linking Mechanical Stimuli and Biochemical Signals
D. P. Felsenfeld
Prepare a graduate-level class covering integrins as force-sensing signal transducers.