*In* a special collection of articles published beginning 6 February 2004,

*Science* Magazine and its online companion sites teamed up to explore one of the hottest interdisciplinary collaborations in science
today: the interface between mathematics and biology. In

*Science*, News, Viewpoint, and Review articles covered how mathematics and computation are informing biology on a wide variety of
fronts, the need for incorporating quantitative approaches into bioscience curricula, and some of the uses -- and abuses --
of mathematical models for biological systems. The

Signal Transduction Knowledge Environment focused on computational models of cell signaling, with Reviews, Protocols, and a special discussion forum. The

Science of Aging Knowledge Environment looked at mathematical approaches to studying several issues of interest to the aging-research community. And

Science's Next Wave offered a month-long series on careers at the math-biology interface.