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1999 Grand Prize Winner

Figure 1Victor E. Velculescu received the grand prize for his essay, "Tantalizing Transcriptomes--SAGE and Its Use in Global Gene Expression Analysis." Dr. Velculescu was born on 16 August 1970 in Bucharest, Romania, and grew up in Thousand Oaks, California. In 1992, he earned his bachelor's degree in the Department of Biological Sciences at Stanford University. He later attended the Johns Hopkins University School of Medicine where he was awarded his Ph.D. in the Program of Human Genetics and Molecular Biology in 1998 and his M.D. in 1999. His doctoral work on the development and application of SAGE to analyze gene expression patterns was performed in the laboratory of Ken Kinzler at the Johns Hopkins Oncology Center. Since January 1999, Dr. Velculescu has been working as a postdoctoral fellow in the laboratory of Bert Vogelstein at the Johns Hopkins Oncology Center.

Regional Winners

Figure 2Europe: Giles E. Hardingham, for his essay, "The Flexibility of the Calcium Signal in Activating Gene Expression," reporting work performed at the Medical Research Council's (MRC) Laboratory of Molecular Biology, in Cambridge, UK. Dr. Hardingham was born in Wimbledon, London, in 1973 and was raised in a family of scientists. After studying Natural Sciences at Cambridge University, he moved to Hilmar Bading's group at the MRC, where he performed his doctoral research. He is now an MRC Fellow at the MRC laboratory of Molecular Biology and a Research Fellow of Clare College, Cambridge, where he continues to study the activation of gene expression in hippocampal neurons.

Figure 3North America: Lisa Goodrich, for her essay, "Patching Together Development and Disease," based on work performed in the Department of Developmental Biology at Stanford University. Dr. Goodrich was born in Washington, DC, and grew up in Boston, MA. She worked as an undergraduate at Harvard in the laboratory of John Dowling, in which she studied the development of the retina in zebrafish. After a year working on the development of ultraviolet photoreceptors in salmon in the laboratory of Yvette Kunz at University College Dublin in Ireland, she joined Matthew Scott's lab at Stanford for her doctoral work on the role of vertebrate patched genes in neural development and disease. Dr. Goodrich is now a postdoctoral fellow with Marc Tessier-Lavigne at the University of California, San Francisco where she is screening mouse genes for novel axon guidance receptors.

Figure 1Europe: The second European regional winner was Marilia Cascalho, for her essay, "Mismatch Repair and Somatic Hypermutation--A Tale of a Double-Edged Sword," based on her thesis research at the University of California at San Francisco. Dr. Cascalho, born in Lisbon, Portugal, received her M.D. degree in 1986 at the Lisbon Medical School, University of Lisbon in Portugal. During a fellowship funded by the Juvenile Diabetes Foundation with Åke Lernmark at the Hagedorn Research Laboratory in Denmark, she contributed to the identification of a diabetes autoantigen. Then at the University of California at San Francisco, she performed her doctoral work with Matthias Wabl on the mechanisms of somatic mutation. Since 1999, Dr. Cascalho has been at the Mayo Clinic in Rochester, MN.

Figure 4Japan: Toshimasa Yamauchi, for his essay, "Discovery of Novel Cross-Talk Between the Cytokine Receptor Superfamily and the Growth Factor Receptor Signal Transduction Pathway," reporting work done at the Graduate School of Medicine, University of Tokyo, Tokyo, Japan. Dr. Yamauchi was born in Kyoto, Japan, and received his M.D. from the Faculty of Medicine and his Ph.D. at the University of Tokyo, Graduate School of Medicine. He described the cross-talk between cytokine and growth factor receptors while working under the direction of Takashi Kadowaki and Yoshio Yazaki, in the Third Department of Internal Medicine, Faculty of Medicine, at the University of Tokyo. Dr. Yamauchi holds a Research Fellowship from the Japan Society for the Promotion of Young Scientists at the Graduate School of Medicine, University of Tokyo, where he is studying the signal transduction pathways of hormones.