In the 20 May 2010 edition of ScienceExpress, Gibson et al. report the creation of a bacterial cell controlled by a chemically synthesized genome. A related News story by E. Pennisi highlights the new work, which involved stepwise creation of a bacterial chromosome and the transfer of it into a related bacterium, where it replaced the native DNA.

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Science Express

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

Gibson et al.

Abstract | PDF | Supporting Online Material

News

Synthetic Genome Brings New Life to Bacterium

Elizabeth Pennisi

Summary | Full Text | PDF

Answers to Reader Questions

Science reporter Elizabeth Pennisi, and Mark Bedau, a philosopher and scientist at Reed College in Portland, Oregon, and editor of the scientific journal Artificial Life, respond to selected reader questions.