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Special Online Collection: Topics in Virology

Jump to features in special collection:

This week, Science and the Signal Transduction Knowledge Environment (STKE) team up to explore the "virosphere" -- a parallel realm ubiquitously influential in our everyday lives. In Science, News, Review, and Perspective articles examine the role of viruses in nanotechnology and long-term molecular evolution, and the response of cells and the immune system to viral attack. And articles in STKE offer examples of how viruses and other pathogens exploit cell signaling pathways to achieve their own ends..

In Science

INTRODUCTION

Paradigms in the Virosphere >
C. Ash, S. Hurtley, M. Lavine, and S. Simpson

NEWS

Did DNA Come From Viruses? >
C. Zimmer

PERSPECTIVE

Viruses: Making Friends with Old Foes >
T. Douglas and M. Young

REVIEW

Aggresomes and Autophagy Generate Sites for Virus Replication >
T. Wileman

REVIEW

Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente >
A. García-Sastre and C. A. Biron

On the Science Podcast

This week's show includes interviews with Trevor Douglas on viruses as a platform for nanotech and Science deputy news editor Leslie Roberts on the worldwide campaign to eradicate the polio virus.

In Science's Signal Transduction Knowledge Environment

EDITORIAL GUIDE

Focus Issue: Viruses -- Miniature Machiavellis of the Signaling World? >
E. M. Adler
Viruses manipulate signaling pathways in the host cell to ensure their own replication and survival.

REVIEW

Signaling During Pathogen Infection >
S. Münter, M. Way, F. Frischknecht
Pathogens manipulate host cell-signaling pathways to achieve efficient entry, replication, and exit during their infection cycles.

REVIEW

Notch and Wnt Signaling: Mimicry and Manipulation by Gamma Herpesviruses >
S. D. Hayward, J. Liu, M. Fujimuro
EBV and KSHV exploit the Notch and Wnt pathways in B cells to advance their own life cycles.

PERSPECTIVE

Viral Modulators of Cullin RING Ubiquitin Ligases: Culling the Host Defense >
M. Barry and K. Früh
Viruses hijack the host ubiquitination machinery to control a range of cellular processes.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)